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001-es BibID:	BIBFORM070610
Első szerző:	Kovács Edina (neurológus)
Cím:	Long-term treatment of refractory myasthenia gravis with subcutaneous immunoglobulin / Kovács Edina, Dankó Katalin, Nagy-Vincze Melinda, Csiba László, Boczán Judit
Dátum:	2017
ISSN:	1756-2856 1756-2864
Megjegyzések:	Subcutaneous administration of immunoglobulin (SCIG) is an emerging alternative therapy for immune neuropathies, offering the advantage of increased patient autonomy by home administration, lower rate of treatment-related reactions, and decrease of costs. Intravenous immunoglobulin (IVIG) has long been used for management of acute exacerbations for myasthenia. Here we report two cases of treatment-refractory myasthenic patients (one generalized and one laryngeal MG) successfully controlled with regular long-term application of SCIG. Chronic steroid dose could be decreased significantly upon SCIG use at both cases. We propose that SCIG can be a useful tool to treat therapy-refractory MG patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban subcutaneous immunoglobulin refractory myasthenia gravis laryngeal myasthenia gravis
Megjelenés:	Therapeutic Advances in Neurological Disorders. - 9 (2017), p. 1-4. -
További szerzők:	Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus) Nagy-Vincze Melinda (1985-) (orvos) Csiba László (1952-) (neurológus, pszichiáter) Boczán Judit (1972-) (neurológus)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00043 GINOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM129305
Első szerző:	Kozák Márk (neurológus)
Cím:	Prevalence of Elevated CK Levels, Myositis-Specific and Myositis-Associated Antibodies, Myositis, and Other Neuromuscular Diseases in Myasthenia Gravis Patients : Experience from an Eastern European Tertiary Center / Márk Kozák, Edina Kovács, Melinda Nagy-Vincze, Attila Tóth, Judit Boczán
Dátum:	2025
ISSN:	2077-0383
Megjegyzések:	Myasthenia gravis (MG) and idiopathic inflammatory myopathy (IIM) are autoimmune diseases that affect the musculoskeletal system. The association of the two diseases is rare. Their management is different, so it is important to recognize the concomitant presentation. Methods: In this cross-sectional study, we study the presence of CK elevation, myositis-specific and myositis-associated antibodies (MSA/MAA), and vitamin D levels in a cohort of 101 MG patients. Electromyography, limb magnetic resonance imaging (MRI), and, in some cases, muscle biopsy were performed when IIM was suspected. We reviewed the patients' medical records to access the results of these tests if they had been performed previously. Results: CK elevation was detected in 10 patients (9.9%). We identified one case of anti-Jo-1 antibody-positive polymyositis and two cases of possible myositis. MSA/MAA antibodies were not found in the patients with high CK levels, except for the one with anti-Jo-1-positive IIM. One patient with elevated CK levels had an overlapping muscular dystrophy. MSA/MAA antibodies were detected in 19 patients (18.8%). A total of 37% had high-titer antibodies and concomitant systemic autoimmune diseases, while 63% had low-titer antibodies, most of whom had no systemic autoimmune disease. Low serum vitamin D levels were found in 67.3% of patients. Comparison of myasthenia gravis composite (MGC) scores between patients with low and normal vitamin D levels did not show a statistically significant difference. Conclusions: Our results may raise awareness among neuromuscular specialists caring for MG patients of the possibility of associated myositis or other neuromuscular diseases and the need to assess vitamin D levels. Although deficiency was frequent, its impact on MG severity remains unclear, necessitating further investigation into its immunological relevance.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk myasthenia gravis myositis idiopathic inflammatory myopathy (IIM) elevated CK levels MSA MAA vitamin D
Megjelenés:	Journal of Clinical Medicine. - 14 : 7 (2025), p. 1-13. -
További szerzők:	Kovács Edina (1983-) (neurológus) Nagy-Vincze Melinda (1985-) (orvos) Tóth Attila (1971-) (biológus) Boczán Judit (1972-) (neurológus)
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