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001-es BibID:	BIBFORM123185
035-os BibID:	(Scopus)85201523429 (WoS)001293598800001
Első szerző:	Fésüs Adina (gyógyszerész)
Cím:	The effect of the antibiotic stewardship program (ASP) on community-acquired pneumonia (CAP) : a before-after study / Adina Fésüs, Phiona Baluku, Éva Sipos, Sándor Somodi, Enikő Berczi-Kun, István Lekli, Ildikó Bácskay, Ria Benkő, Attila Vaskó
Dátum:	2024
Megjegyzések:	Background: Community-acquired pneumonia (CAP) is one of the leading causes of death worldwide. Antibiotic stewardship program (ASP) has been implemented to improve rational and responsible antibiotic use by encouraging guideline adherence. Objective: This retrospective observational before?after study aimed to evaluate whether the ASP may improve guideline adherence, antibiotic exposure, and clinical outcomes in patients hospitalized due to CAP in Hungary. Methods: The study was conducted at a pulmonology department of a tertiary care medical center in Hungary. The ASP implementation consisted of written and published guidelines available to all professionals, continuous supervision, and counseling services on antibiotic therapies at an individual level, with the aim of ensuring compliance with CAP guidelines. Overall guideline adherence (agent selection, route of administration, and dose), clinical outcomes (length of stay and 30-day mortality), antibiotic exposure, and direct costs were compared between the two periods. Fisher's exact test and t-test were applied to compare categorical and continuous variables, respectively. P-values below 0.05 were defined as significant. Results: Significant improvement in overall CAP guideline adherence (30.2%), sequential therapy (10.5%), and a significant reduction in the total duration of antibiotic therapy (13.5%) were observed. Guideline non-adherent combination therapies with metronidazole decreased significantly by 28.1%. Antibiotic exposure decreased by 7.2%, leading to a significant decrease in direct costs (23.6%). Moreover, the ASP had benefits for clinical outcomes, and length of stay decreased by 13.5%. Conclusion: The ASP may play an important role in optimizing empirical antibiotic therapy in CAP having a sustained long-term effect.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk community-acquired pneumonia hospitalized patients empirical antibiotic therapy antibiotic stewardship clinical outcomes intervention
Megjelenés:	Frontiers in Pharmacology. - 15 (2024), p. 1-12. -
További szerzők:	Baluku, Phiona Sipos Éva (1989-) (gyógyszerész) Somodi Sándor (1977-) (belgyógyász) Berczi-Kun Enikő Lekli István (1981-) (gyógyszerész) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Benkő Ria Vaskó Attila (1976-) (tüdőgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114946
Első szerző:	Fésüs Adina (gyógyszerész)
Cím:	Evaluation of the antioxidant effect of kd15 and kd36 newly synthetized molecules / Adina Fésüs, Anita Kónya-Ábrahám, Éva Sipos, Kitti Szőke, István Bak, Attila Kiss-Szikszai, István Lekli
Dátum:	2023
Megjegyzések:	KD molecules are national developed halogen-containing chromone (back-bone structure of flavonoids) derivatives with antioxidant effect. In this study our aim was to investigate whether the pretreatment with KD15 and KD36 molecules have a protective effect against hypoxia-reoxygenation (H/R) induced acute injury on cardiac myocytes. In our series of experiments H9c2 rat cardiomyoblast cells were treated for 24 hours and the Ic50 value of the molecules was determined. After that, we investigated the cells viability in the presence of H2O2 using MTT assay. The concentrations of 3 and 10 ?M proved to be the most effective. Subsequently, these concentrations were used to pretreat cardiomyocytes, followed by four/three hours of H/R. Cell viability was determined by trypan blue (dye) exclusion test. Furthermore, lactate dehydrogenase (LDH) assay was used to confirm these results. Western blot analysis was used to examine the expression levels of the proteins involved in apoptosis and autophagy. Our findings demonstrate that the pretreatment with both molecules significantly improved the cardiomyocytes viability after H/R. However, the 10 ?M concentration proved to be more effective for both molecules. Moreover, the KD36 molecule was less cytotoxic. Furthermore, we found a significant decrease in the level of the oxidative stress caused by H/R, leading to an increased release of LDH. At the same time, the activities of cytoprotective antioxidant enzymes, heme oxygenase-1 (HO-1), superoxide dismutase (SOD), and catalase (CAT) were also increased. Overall, we found that KD15 and KD36 molecules may have a beneficial effect in prevention of H/R-induced cytotoxicity through the reduction of oxidative stress.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok előadáskivonat könyvrészlet
Megjelenés:	FAMÉ 2023 Mátraháza 7-9 June 2023 : Programme Oral and Poster Abstract / org. Hungarian Society For Experimental And Clinical Pharmacology, Hungarian Physiological Society, Hungarian Society For Microcirculation And Vascular Biology . - p. 223.
További szerzők:	Ábrahám Anita (1982-) (vegyész) Sipos Éva (1989-) (gyógyszerész) Szőke Kitti (1989-) (gyógyszerész) Bak István (1975-) (vegyész, analitikus, farmakológus) Kiss-Szikszai Attila (1975-) (vegyész, műszeres-analitikus szakvegyész) Lekli István (1981-) (gyógyszerész)
Pályázati támogatás:	NKFI-143360 Egyéb TKP2021-EGA-18 Egyéb
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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