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001-es BibID:	BIBFORM109087
035-os BibID:	(WoS)000939624800001 (Scopus)85149044317
Első szerző:	Buttia, Chepkoech
Cím:	Prognostic models in COVID-19 infection that predict severity : a systematic review / Buttia Chepkoech, Llanaj Erand, Raeisi-Dehkordi Hamidreza, Kastrati Lum, Amiri Mojgan, Meçani Renald, Taneri Petek Eylul, Ochoa Sergio Alejandro Gómez, Raguindin Peter Francis, Wehrli Faina, Khatami Farnaz, Espínola Octavio Pano, Rojas Lyda Z., de Mortanges Aurélie Pahud, Macharia-Nimietz Eric Francis, Alijla Fadi, Minder Beatrice, Leichtle Alexander B., Lüthi Nora, Ehrhard Simone, Que Yok-Ai, Fernandes Laurenz Kopp, Hautz Wolf, Muka Taulant
Dátum:	2023
ISSN:	0393-2990
Megjegyzések:	Current evidence on COVID-19 prognostic models is inconsistent and clinical applicability remains controversial. We per- formed a systematic review to summarize and critically appraise the available studies that have developed, assessed and/or validated prognostic models of COVID-19 predicting health outcomes. We searched six bibliographic databases to identify published articles that investigated univariable and multivariable prognostic models predicting adverse outcomes in adult COVID-19 patients, including intensive care unit (ICU) admission, intubation, high-flow nasal therapy (HFNT), extracor- poreal membrane oxygenation (ECMO) and mortality. We identified and assessed 314 eligible articles from more than 40 countries, with 152 of these studies presenting mortality, 66 progression to severe or critical illness, 35 mortality and ICU admission combined, 17 ICU admission only, while the remaining 44 studies reported prediction models for mechanical ventilation (MV) or a combination of multiple outcomes. The sample size of included studies varied from 11 to 7,704,171 participants, with a mean age ranging from 18 to 93 years. There were 353 prognostic models investigated, with area under the curve (AUC) ranging from 0.44 to 0.99. A great proportion of studies (61.5%, 193 out of 314) performed internal or external validation or replication. In 312 (99.4%) studies, prognostic models were reported to be at high risk of bias due to uncertainties and challenges surrounding methodological rigor, sampling, handling of missing data, failure to deal with overfitting and heterogeneous definitions of COVID-19 and severity outcomes. While several clinical prognostic models for COVID-19 have been described in the literature, they are limited in generalizability and/or applicability due to deficiencies in addressing fundamental statistical and methodological concerns. Future large, multi-centric and well-designed prognostic prospective studies are needed to clarify remaining uncertainties.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 Prediction models Mortality ICU Systematic review Biomarkers
Megjelenés:	European Journal Of Epidemiology. - 38 : 4 (2023), p. 355-372. -
További szerzők:	Llanaj, Erand (1988-) (táplálkozási epidemiológus) Raeisi-Dehkordi, Hamidreza Kastrati, Lum Amiri, Mojgan Meçani, Renald Taneri, Petek Eylul Ochoa, Sergio Alejandro Gómez Raguindin, Peter Francis Wehrli, Faina Khatami, Farnaz Espínola, Octavio Pano Rojas, Lyda Z. de Mortanges, Aurélie Pahud Macharia-Nimietz, Eric Francis Alijla, Fadi Minder, Beatrice Leichtle, Alexander B. Lüthi, Nora Ehrhard, Simone Que, Yok-Ai Fernandes, Laurenz Kopp Hautz, Wolf E. Muka, Taulant
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM099767
035-os BibID:	(WoS)000737102800002 (Scopus)85122267234
Első szerző:	Llanaj, Erand (táplálkozási epidemiológus)
Cím:	Effect of oat supplementation interventions on cardiovascular disease risk markers : a systematic review and meta-analysis of randomized controlled trials / Llanaj Erand, Dejanovic Gordana M., Valido Ezra, Bano Arjola, Gamba Magda, Kastrati Lum, Minder Beatrice, Stojic Stevan, Voortman Trudy, Marques-Vidal Pedro, Stoyanov Jivko, Metzger Brandon, Glisic Marija, Kern Hua, Muka Taulant
Dátum:	2022
ISSN:	1436-6207
Megjegyzések:	Purpose Oat supplementation interventions (OSIs) may have a beneficial effect on cardiovascular disease (CVD) risk. However, dietary background can modulate such effect. This systematic review assesses the effects of OSIs on CVD risk markers among adults, accounting for different dietary backgrounds or control arms. Methods We included randomized clinical trials (RCTs) that assessed the effect of oat, oat beta-glucan-rich extracts or avenanthramides on CVD risk markers. Results Seventy-four RCTs, including 4937 predominantly hypercholesterolemic, obese subjects, with mild metabolic disturbances, were included in the systematic review. Of these, 59 RCTs contributed to the meta-analyses. Subjects receiving an OSI, compared to control arms without oats, had improved levels of total cholesterol (TC) [weighted mean difference and (95% CI) - 0.42 mmol/L, (- 0.61; - 0.22)], LDL cholesterol [- 0.29 mmol/L, (- 0.37; - 0.20)], glucose [- 0.25 nmol/L, (- 0.36; - 0.14)], body mass index [- 0.13 kg/m(2), (- 0.26; - 0.01)], weight [- 0.94 kg, (- 1.84: - 0.05)], and waist circumference [- 1.06 cm, (- 1.85; - 0.27)]. RCTs on inflammation and/or oxidative stress markers were scarce and with inconsistent findings. RCTs comparing an OSI to heterogeneous interventions (e.g., wheat, eggs, rice, etc.), showed lowered levels of glycated haemoglobin, diastolic blood pressure, HDL cholesterol and apolipoprotein B. The majority of included RCTs (81.1%) had some concerns for risk of bias. Conclusion Dietary OSIs resulted in lowered levels of blood lipids and improvements in anthropometric parameters among participants with predominantly mild metabolic disturbances, regardless of dietary background or control. Further high-quality trials are warranted to establish the role of OSIs on blood pressure, glucose homeostasis and inflammation markers.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	European Journal Of Nutrition. - 61 : 4 (2022), p. 1749-1778. -
További szerzők:	Dejanovic, Gordana M. Valido, Ezra Bano, Arjola Gamba, Magda Kastrati, Lum Minder, Beatrice Stojic, Stevan Voortman, Trudy Marques-Vidal, Pedro Stoyanov, Jivko Metzger, Brandon Glisic, Marija Kern, Hua Muka, Taulant
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM087474
035-os BibID:	(WoS)000561986500001 (Scopus)85089701413
Első szerző:	Taneri, Petek Eylul
Cím:	Anemia and iron metabolism in COVID-19 : a systematic review and meta-analysis / Petek Eylul Taneri, Sergio Alejandro Gómez-Ochoa, Erand Llanaj, Peter Francis Raguindin, Lyda Z. Rojas, Zayne Milena Roa-Díaz, Dante Salvador Jr., Dion Groothof, Beatrice Minder, Doris Kopp-Heim, Wolf E. Hautz, Michele F. Eisenga, Oscar H. Franco, Marija Glisic, Taulant Muka
Dátum:	2020
ISSN:	0393-2990
Megjegyzések:	Iron metabolism and anemia may play an important role in multiple organ dysfunction syndrome in Coronavirus disease 2019 (COVID-19). We conducted a systematic review and meta-analysis to evaluate biomarkers of anemia and iron metabolism (hemoglobin, ferritin, transferrin, soluble transferrin receptor, hepcidin, haptoglobin, unsaturated iron-binding capacity, erythropoietin, free erythrocyte protoporphyrine, and erythrocyte indices) in patients diagnosed with COVID-19, and explored their prognostic value. Six bibliographic databases were searched up to August 3rd 2020. We included 189 unique studies, with data from 57,563 COVID-19 patients. Pooled mean hemoglobin and ferritin levels in COVID-19 patients across all ages were 129.7 g/L (95% Confidence Interval (CI), 128.51; 130.88) and 777.33 ng/mL (95% CI, 701.33; 852.77), respectively. Hemoglobin levels were lower with older age, higher percentage of subjects with diabetes, hypertension and overall comorbidities, and admitted to intensive care. Ferritin level increased with older age, increasing proportion of hypertensive study participants, and increasing proportion of mortality. Compared to moderate cases, severe COVID-19 cases had lower hemoglobin [weighted mean difference (WMD), - 4.08 g/L (95% CI - 5.12; - 3.05)] and red blood cell count [WMD, - 0.16 x 10(12)/L (95% CI - 0.31; - 0.014)], and higher ferritin [WMD, - 473.25 ng/mL (95% CI 382.52; 563.98)] and red cell distribution width [WMD, 1.82% (95% CI 0.10; 3.55)]. A significant difference in mean ferritin levels of 606.37 ng/mL (95% CI 461.86; 750.88) was found between survivors and non-survivors, but not in hemoglobin levels. Future studies should explore the impact of iron metabolism and anemia in the pathophysiology, prognosis, and treatment of COVID-19.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk COVID-19 SARS-CoV-2
Megjelenés:	European Journal Of Epidemiology. - 35 : 8 (2020), p. 763-773. -
További szerzők:	Gómez-Ochoa, Sergio Alejandro Llanaj, Erand (1988-) (táplálkozási epidemiológus) Raguindin, Peter Francis Rojas, Lyda Z. Roa-Díaz, Zayne Milena Salvador, Dante Groothof, Dion Minder, Beatrice Kopp-Heim, Doris Hautz, Wolf E. Eisenga, Michele F. Franco, Oscar H. Glisic, Marija Muka, Taulant
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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