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001-es BibID:	BIBFORM109702
035-os BibID:	(Scopus)85151612301 (WoS)000956763900001
Első szerző:	Árokszállási Tamás (neurológus)
Cím:	Elevated Blood Alcohol Concentration Is Associated with Improved Clinical Outcomes of Intravenous Thrombolysis Treatment in Acute Ischemic Stroke Patients : A Retrospective Study / Árokszállási Tamás, Balogh Eszter, Orbán-Kálmándi Rita, Pásztor Máté, Árokszállási Anita, Nagy Edit Boglárka, Belán Ivett, May Zsolt, Csépány Tünde, Csiba László, Bagoly Zsuzsa, Oláh László
Dátum:	2023
ISSN:	2077-0383
Megjegyzések:	Background: Intravenous thrombolysis (IVT) improves acute ischemic stroke (AIS) outcomes, but with limited success. In addition, ethanol potentiates the effect of r-tPA in ischemia models. Methods: The effect of acute alcohol consumption on IVT outcomes was investigated in a retrospective cohort study. AIS patients with detectable blood alcohol concentration (BAC) during IVT were included (alcohol group; n = 60). For each case, 3 control subjects who underwent IVT but denied alcohol consumption were matched in terms of age, sex, affected brain area, and stroke severity. Outcomes were determined using the NIHSS at 7 days and the modified Rankin scale (mRS) at 90 days. Results: Patients were younger and had a less severe stroke than in a standard stroke study. Favorable long-term outcomes (mRS 0?2) occurred significantly more frequently in the alcohol group compared to controls (90% vs. 63%, p < 0.001). However, the rates of hemorrhagic transformation were similar. Multiple logistic regression models identified elevated BAC as a significant protective factor against unfavorable short-term (OR: 0.091, 95% CI: 0.036?0.227, p < 0.001) and long-term outcomes (OR: 0.182, 95% CI: 0.062?0.535, p = 0.002). In patients with BAC > 0.2%, significantly lower NIHSS was observed at 3 and 7 days after IVT vs. in those with 0.01?0.2% ethanol levels. Conclusion: Elevated BAC is associated with improved outcomes in IVT-treated AIS without affecting safety.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk stroke observational study thrombolysis ethanol outcomes
Megjelenés:	Journal of Clinical Medicine. - 12 : 6 (2023), p. 1-13. -
További szerzők:	Balogh Eszter (1991-) (neurológus) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Pásztor Máté Árokszállási Anita (1982-) (orvos) Nagy Edit Boglárka Belán Ivett May Zsolt Csépány Tünde (1956-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos) Oláh László (1967-) (neurológus)
Pályázati támogatás:	Nemzeti Agykutatási Program (NAP) 2017-1.2.1-NKP-2017-00002 Egyéb ELKH-DE Cerebrovascularis Kutatócsoport MTA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM132071
035-os BibID:	(Scopus)105014423937 (WoS)001557797100001
Első szerző:	Ranjbar, Yasamin
Cím:	The Way Back from Tetraplegia or, Rare Neurological Manifestations of Eosinophil Granulomatosis with Polyangiitis / Ranjbar Yasamin, Árokszállási Tamás, Szinay Dorottya, Nagy Edit B., Tarr Tünde, Nagy-Vincze Melinda
Dátum:	2025
ISSN:	2077-0383
Megjegyzések:	Central nervous system (CNS) involvement is an extremely rare manifestation in eosinophilic granulomatosis with polyangiitis (EGPA), associated with a poor prognosis. Here we present a case of 50-year-old female patient with long-term asthma treatment who presented initially with extreme eosinophilia (56%) and severe progressive ascending paresis, similar to Guillain?Barré syndrome, leading to tetraplegia. After navigating through diagnostic mazes, the diagnosis of EGPA was established based on eosinophilia, myeloperoxidase anti-neutrophil cytoplasmic antibody (MPO-ANCA) positivity, asthma, eosinophil granulomatosis in the gastrointestinal tract, and severe peripheral nervous system involvement, complicated with rare central nervous granulomas and ischemia. With combined immunosuppressive and immunomodulatory treatment including high-dose corticosteroids, rituximab and intravenous immunoglobulin along with symptomatic treatment and planned rehabilitation over 6 months, our patient recovered gradually from tetraplegia and adverse events such as severe infections and osteoporotic fractures. Now, from a 2-year perspective, we can conclude a successful treatment leading to decrease in all of her symptoms. Due to persistent eosinophilia after steroid tapering, she was switched to mepolizumab maintenance treatment and demonstrated continuous improvement of motor and sensory functions. Thanks to periodically repeated rehabilitation, she became self-sufficient and returned to her previous job. Our case highlights that EGPA patients should be treated in a center of expertise due to the rarity of the disease and complexity of diagnosis and treatment. Careful multidisciplinary cooperation, the huge effort of the patient, and a supportive environment can show a way back from immune-mediated tetraplegia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk eosinophil granulomatosis with polyangiitis central nervous system tetraplegia individualized treatment
Megjelenés:	Journal of Clinical Medicine. - 14 : 16 (2025), p. 1-8. -
További szerzők:	Árokszállási Tamás (1988-) (neurológus) Szinay Dorottya (1995-) (Orvos) Nagy Edit B. Tarr Tünde (1976-) (belgyógyász, allergológus és klinikai immunológus) Nagy-Vincze Melinda (1985-) (orvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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