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001-es BibID:	BIBFORM114388
035-os BibID:	(cikkazonosító)1623 (WoS)001055828500001 (Scopus)85168922364
Első szerző:	Kiss Attila (vegyész, angol-magyar szakfordító)
Cím:	The Cytotoxic Properties of Extreme Fungi`s Bioactive Components - An Updated Metabolic and Omics Overview / Attila Kiss, Farhad Hariri Akbari, Andrey Marchev, Viktor Papp, Iman Mirmazloum
Dátum:	2023
ISSN:	2075-1729
Megjegyzések:	Fungi are the most diverse living organisms on planet Earth, where their ubiquitous presence in various ecosystems offers vast potential for the research and discovery of new, naturally occurring medicinal products. Concerning human health, cancer remains one of the leading causes of mortality. While extensive research is being conducted on treatments and their efficacy in various stages of cancer, finding cytotoxic drugs that target tumor cells with no/less toxicity toward normal tissue is a significant challenge. In addition, traditional cancer treatments continue to suffer from chemical resistance. Fortunately, the cytotoxic properties of several natural products derived from various microorganisms, including fungi, are now well-established. The current review aims to extract and consolidate the findings of various scientific studies that identified fungi-derived bioactive metabolites with antitumor (anticancer) properties. The antitumor secondary metabolites identified from extremophilic and extremotolerant fungi are grouped according to their biological activity and type. It became evident that the significance of these compounds, with their medicinal properties and their potential application in cancer treatment, is tremendous. Furthermore, the utilization of omics tools, analysis, and genome mining technology to identify the novel metabolites for targeted treatments is discussed. Through this review, we tried to accentuate the invaluable importance of fungi grown in extreme environments and the necessity of innovative research in discovering naturally occurring bioactive compounds for the development of novel cancer treatments.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk extremophile extremotolerance antitumor novel cancer treatments secondary metabolites multiomics
Megjelenés:	Life. - 13 : 8 (2023), p. 1-41. -
További szerzők:	Hariri Akbari, Farhad Marchev, Andrey Papp Viktor Mirmazloum, Iman
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM117452
035-os BibID:	(cikkazonosító)3178 (WOS)000887807700001 (Scopus)85142431847
Első szerző:	Soorni, Jahad
Cím:	Biochemical and Transcriptional Responses in Cold-Acclimated and Non-Acclimated Contrasting Camelina Biotypes under Freezing Stress / Jahad Soorni, Seyed Kamal Kazemitabar, Danial Kahrizi, Ali Dehestani, Nadali Bagheri, Attila Kiss, Péter Gergő Kovács, István Papp, Iman Mirmazloum
Dátum:	2022
ISSN:	2223-7747
Megjegyzések:	Cold-acclimated and non-acclimated contrasting Camelina (Camelina sativa L.) biotypes were investigated for changes in stress-associated biomarkers, including antioxidant enzyme activity, lipid peroxidation, protein, and proline content. In addition, a well-known freezing tolerance pathway participant known as C-repeat/DRE-binding factors (CBFs), an inducer of CBF expression (ICE1), and a cold-regulated (COR6.6) genes of the ICE-CBF-COR pathway were studied at the transcriptional level on the doubled-haploid (DH) lines. Freezing stress had significant effects on all studied parameters. The cold-acclimated DH34 (a freezing-tolerant line) showed an overall better performance under freezing stress than non-acclimated plants. The non-cold-acclimated DH08 (a frost-sensitive line) showed the highest electrolyte leakage after freezing stress. The highest activity of antioxidant enzymes (glutathione peroxidase, superoxide dismutase, and catalase) was also detected in non-acclimated plants, whereas the cold-acclimated plants showed lower enzyme activities upon stress treatment. Cold acclimation had a significantly positive effect on the total protein and proline content of stressed plants. The qRT-PCR analysis revealed significant differences in the expression and cold-inducibility of CsCBF1-3, CsICE1, and CsCOR6.6 genes among the samples of different treatments. The highest expression of all CBF genes was recorded in the non-acclimated frost-tolerant biotype after freezing stress. Interestingly a significantly higher expression of COR6.6 was detected in cold-acclimated samples of both frost-sensitive and -tolerant biotypes after freezing stress. The presented results provide more insights into freezing tolerance mechanisms in the Camelina plant from both a biochemical point of view and the expression of the associated genes.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cold acclimation freezing tolerance C. sativa electrolyte leakage gene expression
Megjelenés:	Plants-Basel. - 11 : 22 (2022), p. 1-14. -
További szerzők:	Kazemitabar, Seyed Kamal Kahrizi, Danial Dehestani, Ali Bagheri, Nadali Kiss Attila (1971-) (vegyész, angol-magyar szakfordító) Kovács Péter Gergő Papp István Mirmazloum, Iman
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001-es BibID:	BIBFORM115055
035-os BibID:	(WoS)000767582000001 (Scopus)85123994172 (cikkazonosító)359
Első szerző:	Soorni, Jahad
Cím:	Correlational Analysis of Agronomic and Seed Quality Traits in Camelina sativa Doubled Haploid Lines under Rain-Fed Condition / Jahad Soorni, Zahra-Sadat Shobbar, Danial Kahrizi, Federica Zanetti, Kaveh Sadeghi, Sara Rostampour, Péter Gergő Kovács, Attila Kiss, Iman Mirmazloum
Dátum:	2022
ISSN:	2073-4395
Megjegyzések:	Camelina (Camelina sativa (L.) Crantz) is an emerging industrial crop from the Brassicaceae family, with its seed oil and cake being used for food, feed, and fuel applications. In this study, the relationships between economically important agronomic traits including seed yield (SY), days to maturity (DM), 1000-seed weight (TSW), seed protein content (PC), seed oil content (OC), and fatty acid composition in 136 doubled haploid (DH) camelina lines were investigated under rain-fed conditions in two consecutive years. There was prominent diversity among the studied DH lines for the agronomic traits such as seed yield, erucic acid, omega3, protein content, etc. Based on the Pearson correlation analysis of the data, SY was positively correlated with DM and OC, and negatively correlated with TSW, PC, and linolenic acid (C18:3) content. The positive relationships of the main characteristics, relevant to industrial applications, suggest the feasibility of developing new higher-yielding camelina cultivars with high seed oil content. The high seed yield of some camelina lines (DH044 and DH075) during the two growing seasons showed the potential of the lines. On the other hand, the contrasting genotypes for key traits in this study promised a favorable source to develop the superior breeding lines with higher seed yield and food/nonfood traits. Therefore, it can be concluded that the diversity of camelina DH lines traits is crucial for developing new cultivars. Furthermore, the present study reports some significant correlations among the DH lines, which may be useful for the current and future camelina breeding program.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk seed yield components correlation oilseed crop crude protein fatty acid
Megjelenés:	Agronomy-Basel. - 12 : 2 (2022), p.1-13. -
További szerzők:	Shobbar, Zahra-Sadat Kahrizi, Danial Zanetti, Federica Sadeghi, Kaveh Rostampour, Sara Kovács Péter Kiss Attila (1971-) (vegyész, angol-magyar szakfordító) Mirmazloum, Iman
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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