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001-es BibID:	BIBFORM095573
035-os BibID:	(WoS)000688508300032 (Scopus)85113379671 (PubMed)34433068
Első szerző:	Dautan, Daniel
Cím:	Modulation of motor behavior by the mesencephalic locomotor region / Daniel Dautan, Adrienn Kovács, Tsogbadrakh Bayasgalan, Miguel Diaz, Balazs Pal, Juan Mena-Segovia
Dátum:	2021
ISSN:	2211-1247
Megjegyzések:	The mesencephalic locomotor region (MLR) is a functionally-defined area located in the midbrain that serves as an interface between higher-order motor systems (e.g. basal ganglia and cortex) and lower motor neurons (brainstem and spinal cord). The excitatory module of the MLR is composed of the pedunculopontine nucleus (PPN) and the cuneiform nucleus (CnF) and their activation has been proposed to elicit different modalities of movement, but whether differences in connectivity and physiological properties explain their contributions to motor activity is not known. Here we report that CnF-glutamatergic neurons are functionally homogeneous and have short-range axonal projections, whereas PPN-glutamatergic neurons are heterogeneous and maintain long-range connections with other motor circuits, most notably the basal ganglia. Optogenetic activation of CnF-neurons produced short-lasting muscle activation and fast-onset, involuntary motor activity, whereas activation of PPN-neurons produced long-lasting muscle activation, decreased locomotion and disrupted gait. Our results thus reveal a differential contribution to motor behavior in the structures that compose the MLR.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Cell Reports. - 36 : 8 (2021), p. 109594. -
További szerzők:	Kovács Adrienn (1989-) (molekuláris biológus) Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Diaz-Acevedo, Miguel A. Pál Balázs (1975-) (élettanász) Mena-Segovia, Juan
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM133754
Első szerző:	Pocsai Krisztina (élettanász)
Cím:	Neurons of the precuneiform nucleus share structural and functional properties of the mesencephalic locomotor region / Pocsai K., Bayasgalan T., Csemer A., Szücs P., Mena-Segovia J., Pál B.
Dátum:	2025
ISSN:	2045-2322
Megjegyzések:	The mesencephalic locomotor region (MLR) encodes a diverse range of movements, from locomotion to posture and turning behavior. While the cuneiform nucleus (CnF) and pedunculopontine nucleus (PPN), the main components of the MLR, have been recently characterized, little is known about the precuneiform nucleus (PrCnF). To address this gap, we performed somatodendritic morphological analyses and ex vivo functional studies on PrCnF neurons of VGluT2-tdTomato mice and compared them with those of neighboring MLR nuclei. PrCnF neurons exhibited dendritic morphology similar to PPN neurons but distinct from CnF neurons. Functionally, PrCnF neurons displayed higher firing rates and oscillatory activity compared to CnF and PPN neurons, which were correlated with TTX-sensitive high-threshold membrane potential oscillations mediated by the persistent Na? current present in most PrCnF neurons. Unlike PPN and CnF neurons, the majority of PrCnF neurons did not show depolarization-related changes in spike frequency adaptation, indicating that their intrinsic properties support continuous high-frequency spiking. These findings suggest that PrCnF neurons may have a uniform relationship to movement speed similar to CnF neurons and that activation of the PrCnF might be related to higher-speed movements due to their weak spike frequency adaptation and higher firing rates.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Precuneiform nucleus Pedunculopontine nucleus Cuneiform nucleus Glutamatergic neuron Somatodendritic parameters Membrane properties
Megjelenés:	Scientific Reports. - 15 : 1 (2025), p. 1-14. -
További szerzők:	Bayasgalan, Tsogbadrakh (1983-) (Általános orvos) Csemer Andrea (1994-) (molekuláris biológus) Szűcs Péter (1974-) (kutatóorvos) Mena-Segovia, Juan Pál Balázs (1975-) (élettanász)
Pályázati támogatás:	K 146873 NKFIH Stipendium Hungaricum Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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