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001-es BibID:	BIBFORM124996
035-os BibID:	(WoS)001304109300008 (Scopus)85202890777
Első szerző:	Kenessey István
Cím:	The epidemiology of lung cancer in Hungary based on the characteristics of patients diagnosed in 2018 / István Kenessey, Petra Parrag, Mária Dobozi, István Szatmári, András Wéber, Péter Nagy, Csaba Polgár
Dátum:	2024
ISSN:	2045-2322
Megjegyzések:	Among malignant diseases, lung cancer has one of the highest mortality and incidence. Most epidemiological studies conclude that Hungary faces the most severe burden in association with this disease. However, for various reasons estimates and population-based studies show discrepancies. In this study, an intense data cleansing was performed on lung cancer cases that were reported to the Hungarian National Cancer Registry in 2018, and the major clinico-pathological parameters as well as survival characteristics were described. Our population-based figures were compared to the European estimates. As a result of our thorough revision, the corrected incidence of lung cancer has fallen below the number of cases that were reported to the Registry from 11,746 to 9,519. We also demonstrate that Hungary did not show the highest incidence and mortality in Europe, but it is still among the ones with the worst raking countries, with 92.9 and 50.6 age standardized rate per 100 thousand capita among males and females, respectively. Analysis of the annually reported case numbers revealed a gender-specific difference in incidence trends: while from 2001 to 2019 it slightly decreased among males, it increased among females. The most dominant subtype was adenocarcinoma, which was more frequent among female patients. Unfortunately, most of the newly diagnosed cases were in advanced stage; thus, 5 year overall survival was 14.8%. We anticipate that in the longer term, a decrease in incidence and improvement in survival rates may be expected as a result of the development of primary and secondary prevention programs in the country. ? The Author(s) 2024.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cancer registry Incidence International comparison Lung cancer in Hungary
Megjelenés:	Scientific Reports. - 14 : 1 (2024), p. 1-10. -
További szerzők:	Parrag Petra Dobozi Mária Szatmári István Wéber András Nagy Péter (1976-) (vegyész) Polgár Csaba
Pályázati támogatás:	2022-2.1.1-NL-2022-00010 Egyéb TKP2021-EGA-44 Egyéb IV/651/2022/EKF Egyéb
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001-es BibID:	BIBFORM116150
035-os BibID:	(WoS)001085340000073 (Scopus)85173792636
Első szerző:	Orján Erik Márk
Cím:	The anti-inflammatory effect of dimethyl trisulfide in experimental acute pancreatitis / Erik Márk Orján, Eszter Sára Kormányos, Gabriella Mihalekné Fűr, Ágnes Dombi, Emese Réka Bálint, Zsolt Balla, Beáta Adél Balog, Ágnes Dágó, Ahmad Totonji, Zoárd István Bátai, Eszter Petra Jurányi, Tamás Ditrói, Ammar Al-Omari, Gábor Pozsgai, Viktória Kormos, Péter Nagy, Erika Pintér, Zoltán Rakonczay, Lóránd Kiss
Dátum:	2023
ISSN:	2045-2322
Megjegyzések:	Various organosulfur compounds, such as dimethyl trisulfide (DMTS), display anti-inflammatory properties. We aimed to examine the effects of DMTS on acute pancreatitis (AP) and its mechanism of action in both in vivo and in vitro studies. AP was induced in FVB/n mice or Wistar rats by caerulein, ethanol-palmitoleic acid, or L-ornithine-HCl. DMTS treatments were administered subcutaneously. AP severity was assessed by pancreatic histological scoring, pancreatic water content, and myeloperoxidase activity measurements. The behaviour of animals was followed. Pancreatic heat shock protein 72 (HSP72) expression, sulfide, and protein persulfidation were measured. In vitro acinar viability, intracellular Ca2+ concentration, and reactive oxygen species production were determined. DMTS dose-dependently decreased the severity of AP. It declined the pancreatic infiltration of leukocytes and cellular damage in mice. DMTS upregulated the HSP72 expression during AP and elevated serum sulfide and low molecular weight persulfide levels. DMTS exhibited cytoprotection against hydrogen peroxide and AP-inducing agents. It has antioxidant properties and modulates physiological but not pathophysiological Ca2+ signalling. Generally, DMTS ameliorated AP severity and protected pancreatic acinar cells. Our findings indicate that DMTS is a sulfur donor with anti-inflammatory and antioxidant effects, and organosulfur compounds require further investigation into this potentially lethal disease.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 13 : 1 (2023), p. 1-19. -
További szerzők:	Kormányos Eszter Sára Mihalekné Fűr Gabriella Dombi Ágnes Bálint Emese Réka Balla Zsolt Balog Beáta Adél Dágó Ágnes Totonji, Ahmad Bátai István Zoárd Jurányi Eszter Petra Ditrói Tamás (1989-) (vegyész) Al-Omari, Ammar Pozsgai Gábor Kormos Viktória Nagy Péter (1976-) (vegyész) Pintér Erika Rakonczay Zoltán Kiss Loránd (1974-) (vegyész)
Pályázati támogatás:	EFOP-3.6.2-16-2017-00006 EFOP GINOP-2.3.2-15-2016-00034 GINOP
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001-es BibID:	BIBFORM104913
035-os BibID:	(WoS)000387215200001 (Scopus)84994246762
Első szerző:	Szczesny, Bartosz
Cím:	Inhibition of hydrogen sulfide biosynthesis sensitizes lung adenocarcinoma to chemotherapeutic drugs by inhibiting mitochondrial DNA repair and suppressing cellular bioenergetics / Bartosz Szczesny, Michela Marcatti, John R. Zatarain, Nadiya Druzhyna, John E.Wiktorowicz, Péter Nagy, Mark R. Hellmich, Csaba Szabo
Dátum:	2016
ISSN:	2045-2322
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 6 : 1 (2016), p. 1-11. -
További szerzők:	Marcatti, Michela Zatarain, John R. Druzhyna, Nadiya Wiktorowicz, John E. Nagy Péter (1976-) (vegyész) Hellmich, Mark R. Szabó Csaba
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