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001-es BibID:	BIBFORM121449
035-os BibID:	(Scopus)85190593422 (WOS)001203912900001
Első szerző:	Wéber András
Cím:	Global burden of bladder cancer mortality in 2020 and 2040 according to GLOBOCAN estimates / András Wéber, Jerome Vignat, Richa Shah, Eileen Morgan, Mathieu Laversanne, Péter Nagy, István Kenesse, Ariana Znaor
Dátum:	2024
ISSN:	1433-8726
Megjegyzések:	Introduction: In 2020, bladder cancer (BC) was the seventh most prevalent cancer in the world, with 5-year prevalence of more than 1.7 million cases. Due to the main risk factors-smoking and chemical exposures-associated with BC, it is considered a largely preventable and avoidable cancer. An overview of BC mortality can allow an insight not only into the prevalence of global risk factors, but also into the varying efficiency of healthcare systems worldwide. For this purpose, this study analyzes the national mortality estimates for 2020 and projected future trends up to 2040. Materials and methods: Age-standardized mortality rates per 100,000 person-years of BC for 185 countries by sex were obtained from the GLOBOCAN 2020 database, operated by the International Agency for Research on Cancer (IARC). Mortality rates were stratified according to sex and Human Development Index (HDI). BC deaths were projected up to 2040 on the basis of demographic changes, alongside different scenarios of annually increasing, stable or decreasing mortality rates from the baseline year of 2020. Results: In 2020, nearly three times more men died from BC than women, with more than 210,000 deaths in both sexes combined, worldwide. Regardless of gender, more than half of the total BC deaths were from countries with a very high HDI. According to our projections, while the number of deaths for men can only increase up to 54% (from 159 to around 163-245 thousand), for women it is projected to increase two- to three-fold (from 50 to around 119-176 thousand) by 2040. The burden of BC mortality in countries with a very high HDI versus high HDI appears to converge by 2040 for both sexes. Conclusion: Opposite mortality trends by gender highlight the urgent need for immediate interventions to expand anti-tobacco strategies, especially for women. The implementation of more strict occupational health and safety regulations could also prevent exposures associated with BC. Improving the ability to detect BC earlier and access to treatment can have a significant positive impact on reducing mortality rates, minimizing economic costs, and enhancing the quality of life for patients.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Bladder cancer Mortality Projection
Megjelenés:	World Journal of Urology. - 42 : 1 (2024), p. 1-10. -
További szerzők:	Vignat, Jerome Shah, Richa Morgan, Eileen Laversanne, Mathieu Nagy Péter (1976-) (vegyész) Kenessey István Znaor, Ariana
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM116678
035-os BibID:	(Scopus)85170062413 (WoS)001063954400001
Első szerző:	Wéber András
Cím:	Gains in life expectancy from decreasing cardiovascular disease and cancer mortality - an analysis of 28 European countries 1995-2019 / András Wéber, Mathieu Laversanne, Péter Nagy, István Kenessey, Isabelle Soerjomataram, Freddie Bray
Dátum:	2023
ISSN:	0393-2990
Megjegyzések:	Background: Life expectancy (LE) is an indicator of societal progress among rapidly aging populations. In recent decades, the displacement of deaths from cardiovascular disease (CVD) and cancer have been key drivers in further extending LE on the continent, though improvements vary markedly by country, sex, and over time. This study provides a comparative overview of the age-specific contributions of CVD and cancer to increasing LE in the 27 European Union member states, plus the U.K. Methods: Cause-by-age decompositions of national changes in LE were conducted for the years 1995?1999 and 2015?2019 based on the standard approach of multiple decrement life tables to quantify the relative impact over time. The contributions of CVD and cancer mortality changes to differences in LE were computed by sex and age for each of the 28 countries. We examine the difference between the member states before 2004 ("founding countries") and those which accessed the EU after 2004 ("A10 countries"). Results: Among men, declines in CVD mortality in the founding countries of the EU were larger contributors to increasing LE over the last decades than malignant neoplasms: 2.26 years were gained by CVD declines versus 1.07 years for cancer, with 2.23 and 0.84 years gained in A10 countries, respectively. Among women in founding countries, 1.81 and 0.54 additional life years were attributable to CVD and cancer mortality declines, respectively, while in A10 countries, the corresponding values were 2.33 and 0.37 years. Lung and stomach cancer in men, and breast cancer in women were key drivers of gains in LE due to cancer overall, though rising mortality rates from lung cancer diminished the potential impact of increasing female LE in both EU founding (e.g., France, Spain, and Sweden) and A10 countries (e.g., Croatia, Hungary, and Slovenia), notably among cohorts aged 55?70 years. Over the 25 years, the LE gap between the two sets of countries narrowed from 6.22 to 5.59 years in men, and from 4.03 to 3.12 years for women, with diminishing female mortality from CVD as a determinative contributor. Conclusion: This study underscores the continued existence of an East-West divide in life expectancy across the EU27 + 1, evident on benchmarking the founding vs. A10 countries. In EU founding countries, continuous economic growth alongside improved health care, health promotion and protection policies have contributed to steady declines in mortality from chronic diseases, leading to increases in life expectancy. In contrast, less favourable mortality trends in the EU A10 countries indicate greater economic and health care challenges, and a failure to implement effective health policies.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cancer causes of death Cardiovascular mortality Decomposition Geographical visualization Life expectancy
Megjelenés:	European Journal Of Epidemiology. - 38 : 11 (2023), p. 1141-1152. -
További szerzők:	Laversanne, Mathieu Nagy Péter (1976-) (vegyész) Kenessey István Soerjomataram, Isabelle Bray, Freddie
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM113488
035-os BibID:	(Scopus)85158910226 (WoS)001001381400001
Első szerző:	Wéber András
Cím:	Lung cancer mortality in the wake of the changing smoking epidemic: a descriptive study of the global burden in 2020 and 2040 / András Wéber, Eileen Morgan, Jerome Vignat, Mathieu Laversanne, Margherita Pizzato, Harriet Rumgay, Deependra Singh, Péter Nagy, István Kenessey, Isabelle Soerjomataram, Freddie Bray
Dátum:	2023
ISSN:	2044-6055
Megjegyzések:	Objectives - Lung cancer (LC) is the leading cause of cancer death in 2020, responsible for almost one in five (18.0%) deaths. This paper provides an overview of the descriptive epidemiology of LC based on national mortality estimates for 2020 from the International Agency for Research on Cancer (IARC), and in the context of recent tobacco control policies. Design and setting - For this descriptive study, age-standardised mortality rates per 100?000 person-years of LC for 185 countries by sex were obtained from the GLOBOCAN 2020 database and stratified by Human Development Index (HDI). LC deaths were projected to 2040 based on demographic changes alongside scenarios of annually increasing, stable or decreasing rates from the baseline year of 2020. Results - LC mortality rates exhibited marked variations by geography and sex. Low HDI countries, many of them within sub-Saharan Africa, tend to have low levels of mortality and an upward trend in LC deaths is predicted for both sexes until 2040 according to demographic projections, irrespective of trends in rates. In very high HDI countries, including Europe, Northern America and Australia/New Zealand, there are broadly decreasing trends in men whereas in women, rates are still increasing or reaching a plateau. Conclusion - The current and future burden of LC in a country or region largely depends on the present trajectory of the smoking epidemic in its constituent populations, with distinct gender differences in smoking patterns, both in transitioning and transitioned countries. Further elevations in LC mortality are expected worldwide, raising important social and political questions, especially in low-income and middle-income countries.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	BMJ Open. - 13 : 5 (2023), p. 1-8. -
További szerzők:	Morgan, Eileen Vignat, Jerome Laversanne, Mathieu Pizzato, Margherita Rumgay, Harriet Singh, Deependra Nagy Péter (1976-) (vegyész) Kenessey István Soerjomataram, Isabelle Bray, Freddie
Pályázati támogatás:	TKP2021-EGA-44 Egyéb 2022-2.1.1-NL-2022-00010 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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