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001-es BibID:BIBFORM106134
035-os BibID:(WOS)000904416000001 (Scopus)85144635665
Első szerző:Astuti, Putri Kusuma (állattenyésztési genetikus)
Cím:Validation of SNP markers for thermotolerance adaptation in Ovis aries adapted to different climatic regions using KASP-PCR technique / Putri Kusuma Astuti, Daniela Elena Ilie, Dinu Gavojdian, George Wanjala, Bouabid Badaoui, Husein Ohran, Eva Pasic-Juhas, Zoltán Bagi, András Jávor, Szilvia Kusza
Dátum:2022
ISSN:2045-2322
Megjegyzések:A study on 51 SNPs belonging to 29 genes related to heat stress was carried out in 720 sheep from 17 different breeds adapted to different climates from Hungary, Bosnia and Herzegovina, Morocco and Romania, using Kompetitive Allele?Specific Polymerase Chain Reaction. Genotype frequency and the Hardy?Weinberg equilibrium were calculated, followed by a clustering using the Principal Component Analysis. We analyzed the polymorphisms in the following genes analyzed: HSPA12A, HSP90AA1, IL33, DIO2, BTNL2, CSN2, ABCG1, CSN1S1, GHR, HSPA8, STAT3, and HCRT. We emphasized on HSPA12A and HSPA8 genes as they were successfully genotyped in all studied flocks in which genotype frequency patterns were identified. Contrary to previous findings, the A allele for HSPA8 SNP was not observed in the heat tolerant breeds, being found exclusively in cold-tolerant breeds. The principal component analysis could not clearly differentiate the breeds, while plot concentration was slightly varied among the three groups, with HSP90AA1 and IL33 SNPs' loading values significantly contributing to PC1 and PC2. We confirmed previous works that the HSPA12A, HSPA8, HSP90AA1 and IL33 SNPs are potential candidate markers for thermotolerance adaptation in sheep. This research contributes to the genetic variability of SNPs for thermotolerance adaptability in sheep.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 12 (2022), p. 1-9. -
További szerzők:Ilie, Daniela Elena Gavojdian, Dinu Wanjala, George (1984-) (Animal scientist) Badaoui, Bouabid (1979-) (animal genetics engineer) Ohran, Husein Pasic-Juhas, Eva Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Jávor András (1952-) (agrármérnök) Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:EFOP-3.6.2-16-2017-00001
EFOP
2021-1.2.4-TÉT-2021-00014
Egyéb
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2.

001-es BibID:BIBFORM130412
Első szerző:Kichamu, Nelly (Animal scientist)
Cím:Genome-wide analysis provides insight into the genetic diversity and adaptability of Kazakhstan local goats / Nelly Kichamu, GeorgeWanjala, Kairat Dossybayev, Zoltán Bagi, Bakhytzhan Bekmanov, Szilvia Kusza
Dátum:2025
ISSN:2045-2322
Megjegyzések:o understand the genetic structure of local goat populations in Kazakhstan, we present the first comprehensive genomic analysis using a 70 K SNP array, examining 120 samples from six regions. The populations (Kundyzdy, Darbaza, Shokpar, Ushterek, Kenes and Kosseit) are named based on their breeding regions and are referred to ecotypes. Our results present a high genetic diversity, with observed heterozygosity (Ho) ranging from 0.389 to 0.444. Shokpar and Kundyzdy showed excess heterozygosity, while Kosseit and Darbaza had high inbreeding levels. Most populations recorded weak genetic differentiation, except for Ushterek goats, which were more distinct. For adaptability, Runs of Homozygosity (ROH) and Integrated Haplotype Score (iHS) identified 71 genes under selection, with gene ontology enrichment indicating localization as the most represented biological pathway important for cell response. Additionally, over 60% of these genes are co-expressed, suggesting their significant role in survival of these goats in their local environments. Some identified genes, such as NLRC4, HCLS1, IL17D, IL17RE, and IL17RC, were linked to immune response, an important adaptation trait in the context of climate change. This study not only emphasizes on high genetic variability of local goats in Kazakhstan but also lays the groundwork for developing conservation and breeding programs for local goats in Kazakhstan and other similar agroecological regions for adaptability and resilience under changing environmental conditions.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 15 : 1 (2025), p. 1-15. -
További szerzők:Wanjala, George (1984-) (Animal scientist) Dossybayev, Kairat Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Bekmanov, Bakhytzhan Kusza Szilvia (1979-) (agrármérnök)
Pályázati támogatás:DETKA
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3.

001-es BibID:BIBFORM122766
035-os BibID:(Scopus)85198652941
Első szerző:Kichamu, Nelly (Animal scientist)
Cím:Assessing the population structure and genetic variability of Kenyan native goats under extensive production system / Nelly Kichamu, George Wanjala, Ludovic Toma Cziszter, Péter Strausz, Putri Kusuma Astuti, Zoltán Bagi, Szilvia Kusza
Dátum:2024
ISSN:2045-2322
Megjegyzések:Indigenous goats are important to many livelihoods. Despite this, they are subjected to indiscriminate crossbreeding. This afects their genetic variability which is needed to survive in current regime of climate change. The study assessed population structure and genetic diversity of Galla and Small East African goats (SEA) using pedigree information. A total of 7384 animals, 5222 of the Galla and 2162 of the SEA breeds, born between the years 1983 and 2022, were utilized. Individuals with known parents were defned as reference population. From the results, the maximum generation traced for Galla and SEA populations was 14.6 and 14.5, respectively. However, only 6 and 5 generations for Galla and SEA were complete. Pedigree completeness increased with the increasing number of generations. The average generation interval (GI) for Galla and SEA was 3.84 ± 0.04 and 4.4 ± 0.13 years. The average increase in the rate of inbreeding per generation for Galla and SEA was 0.04 and 0.05, with the efective ancestors and founders (fa/fe) ratio being same (1.00) for both breeds. Fifty percent (50%) of the genetic variability in the populations was contributed by 3 and 1 ancestor for Galla SEA, respectively. The efective population size (Ne) was 5.19 and 4.77 for Galla and SEA. Therefore, the current breeding programs should be changed to avoid future genetic bottlenecks in this population. These fndings ofer an opportunity to enhance the current genetic status and management of Kenyan native goats and other regions with similar production systems.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 14 : 1(2024), p. 1-11. -
További szerzők:Wanjala, George (1984-) (Animal scientist) Cziszter, Ludovic Toma Strausz Péter Astuti, Putri Kusuma (1994-) (állattenyésztési genetikus) Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Kusza Szilvia (1979-) (agrármérnök)
Internet cím:DOI
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4.

001-es BibID:BIBFORM122767
035-os BibID:(WoS)001281644800048 (Scopus)85198844931
Első szerző:Kusza Szilvia (agrármérnök)
Cím:Insights into the genomic homogeneity of Moroccan indigenous sheep breeds though the lens of runs of homozygosity / Szilvia Kusza, Bouabid Badaoui, George Wanjala
Dátum:2024
ISSN:2045-2322
Megjegyzések:Numerous studies have indicated that Morocco`s indigenous sheep breeds are genetically homogenous, posing a risk to their survival in the challenging harsh climate conditions where they predominantly inhabit. To understand the genetic behind genetic homogeneity through the lens of runs of homozygosity (ROH), we analyzed the whole genome sequences of fve indigenous sheep breeds (Beni Guil, Ouled Djellal, D`man, Sardi, Timahdite and Admixed).The results from principal component, admixture, Fst, and neighbour joining tree analyses consistently showed a homogenous genetic structure. This structure was characterized by an average length of 1.83 Mb for runs of homozygosity (ROH) segments, with a limited number of long ROH segments (24-48 Mb and> 48 Mb). The most common ROH segments were those ranging from 1-6 Mb. The most signifcant regions of homozygosity (ROH Islands) were mostly observed in two chromosomes, namely Chr1 and Chr5. Specifcally, ROH Islands were exclusively discovered in the Ouled Djellal breed on Chr1, whereas Chr5 exhibited ROH Islands in all breeds. The analysis of ROH Island and iHS technique was employed to detect signatures of selection on Chr1 and Chr5. The results indicate that Chr5 had a high level of homogeneity, with the same genes being discovered across all breeds. In contrast, Chr1 displays some genetic variances between breeds. Genes identifed on Chr5 included SLC39A1, IL23A, CAST, IL5, IL13, and IL4 which are responsible for immune response while genes identifed on Chr1 include SOD1, SLAMF9, RTP4, CLDN1, and PRKAA2. ROH segment profle and efective population sizes patterns suggests that the genetic uniformity of studied breeds is the outcome of events that transpired between 250 and 300 generations ago. This research not only contributes to the understanding of ROH distribution across breeds but helps design and implement native sheep breeding and conservation strategies in Morocco. Future research, incorporating a broader sample size and utilizing the pangenome for reference, is recommended to further elucidate these breeds` genomic landscapes and adaptive mechanisms.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Genomic homogeneity
Indigenous sheep
Morocco
ROH
Megjelenés:Scientific Reports. - 14 : 1 (2024), p. 1-11. -
További szerzők:Badaoui, Bouabid (1979-) (animal genetics engineer) Wanjala, George (1984-) (Animal scientist)
Internet cím:DOI
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5.

001-es BibID:BIBFORM129638
035-os BibID:(Scopus)105003158632 (WoS)001473869700019
Első szerző:Wanjala, George (Animal scientist)
Cím:Genetic diversity and adaptability of native sheep breeds from different climatic zones / George Wanjala, Zoltán Bagi, Dinu Gavojdian, Bouabid Badaoui, Putri Kusuma Astuti, Alexandru Mizeranschi, Elena Ilisiu, Husein Ohran, Eva Pasic Juhas, Dimitrios Loukovitis, Aldona Kawȩcka, Rūta Šveistienẻ, Zsolt Becskei, Péter Strausz, Nelly Kichamu, Szilvia Kusza
Dátum:2025
ISSN:2045-2322
Megjegyzések:To better understand the genetic architecture and adaptability of native sheep, 22 breeds were genotyped using ovine50K SNP chips. Eleven additional populations from open-source repositories were included. Cross population Extended Haplotype Homozygosity (XP-EHH) and Relative Scaled Haplotype Homozygosity (Rsb) haplotype-based approaches were used to identify genetic variations influencing the adaptation of local sheep breeds to different climatic zones. The results indicate that all breeds exhibited high but declining genetic diversity levels, with a larger proportion of genetic variation explained by development history and refined by geographical origin, as shown by principal component analysis and Neighbor Net graphs. Admixture analysis revealed high admixture levels in European and North African breeds. Using XP-EHH and Rsb methods, 371 genes were putatively under selection, with only nine common among all population pairs, highlighting unique adaptability. Most identified genes, including Interleukin (IL) and cluster differentiation (CD) gene families underlie immune responses, emphasizing their role in resilience to climate change effects. These findings support that indigenous sheep breeds have retained significant genetic diversity, but improper genetic management may threaten it. Additionally, the research emphasizes that indigenous sheep breeds' unique adaptability to specific climatic zones makes them valuable genetic assets for developing climate-resilient breeds.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 15 : 14143 (2025), p. 1-13. -
További szerzők:Bagi Zoltán (1987-) (természetvédelmi mérnök, állatgenetika) Gavojdian, Dinu Badaoui, Bouabid (1979-) (animal genetics engineer) Astuti, Putri Kusuma (1994-) (állattenyésztési genetikus) Mizeranschi, Alexandru Eugeniu Ilisiu, Elena Ohran, Husein Pasic Juhas, Eva Loukovitis, Dimitrios Kawęcka, Aldona Šveistienẻ, Rūta Becskei Zsolt Strausz Péter Kichamu, Nelly (1978-) (Animal scientist) Kusza Szilvia (1979-) (agrármérnök)
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