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001-es BibID:	BIBFORM122029
Első szerző:	Lieber Attila
Cím:	The role of immunotherapy in early stage and metastatic NSCLC / Attila Lieber, Attila Makai, Zsuzsanna Orosz, Tamás Kardos, Susil Joe Isaac, Ilona Tornyi, Nora Bittner
Dátum:	2024
Megjegyzések:	In the past decade we have seen new advances and by that remarkable progress in therapeutic possibilities of non-small cell lung cancer (NSCLC). Among cytostatic therapies with new approaches in molecularly targeted therapies, we see new development in a wide range of applications for immunotherapies. In this review we discuss the new potential modalities for the use of immune checkpoint inhibitors (ICIs) in frontline, including ? early stage (perioperative) and metastatic setting. The perioperative use of ICIs in both neoadjuvant and adjuvant setting may show benefit for patients. In early-stage NSCLC (from stage IIB and above) multimodal approach is recommended as gold standard for the treatment. After surgical resection platinum-based adjuvant chemotherapy was the standard of care for many years. Based on the benefit in disease free survival, the approval of adjuvant atezolizumab and adjuvant pembrolizumab were a significant breakthrough. In metastatic setting, the use of immune checkpoint inhibitor with chemotherapy, regardless of PD-L1 expression or ICI alone (PD-L1 expression equal or greater than 50%) improves overall survival and progression-free survival as well.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban folyóiratcikk NSCLC PD-(L)1 ICI perioperative metastatic
Megjelenés:	Pathology and Oncology Research. - "Accepted by Publisher" (2024). -
További szerzők:	Makai Attila (1987-) (tüdőgyógyász szakorvos) Orosz Zsuzsanna (1974-) (Orvos) Kardos Tamás (1980-) (pulmonológus, klinikai onkológus) Susil, Joe Isaac Tornyi Ilona (1982-) (molekuláris biológus) Bittner Nóra (1963-) (orvos)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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