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001-es BibID:	BIBFORM119541
Első szerző:	Dienes Beatrix (élettanász, molekuláris biológus)
Cím:	The contribution of PIEZO1 channels modifies our picture of skeletal muscle contraction / Beatrix Dienes, Peter Szentesi, Laszlo Szabo, Zsuzsanna Édua Magyar, Zsigmond Kovacs, Tamás Bazsó, Mónika Gönczi, László Csernoch
Dátum:	2024
ISSN:	0006-3495
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Biophysical Journal. - 123 : 3_Suppl_1 (2024), p. 243a. -
További szerzők:	Szentesi Péter (1967-) (élettanász) Szabó László (1994-) (molekuláris biológus) Magyar Zsuzsanna Édua (1993-) (molekuláris biológus) Kovács Zsigmond Máté (1995-) (orvos) Bazsó Tamás (1974-) (ortopéd sebész) Gönczi Mónika (1974-) (élettanász) Csernoch László (1961-) (élettanász)
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001-es BibID:	BIBFORM096191
035-os BibID:	(scopus)85114049778 (wos)000694373200001
Első szerző:	Dienes Csaba (gyógyszerész)
Cím:	Electrophysiological Effects of the Transient Receptor Potential Melastatin 4 Channel Inhibitor (4-Chloro-2-(2-chlorophenoxy)acetamido) Benzoic Acid (CBA) in Canine Left Ventricular Cardiomyocytes / Csaba Dienes, Tamás Hézső, Dénes Zsolt Kiss, Dóra Baranyai, Zsigmond Máté Kovács, László Szabó, János Magyar, Tamás Bányász, Péter P. Nánási, Balázs Horváth, Mónika Gönczi, Norbert Szentandrássy
Dátum:	2021
ISSN:	1661-6596 1422-0067
Megjegyzések:	Transient receptor potential melastatin 4 (TRPM4) plays an important role in many tissues, including pacemaker and conductive tissues of the heart, but much less is known about its electrophysiological role in ventricular myocytes. Our earlier results showed the lack of selectivity of 9-phenanthrol, so CBA ((4-chloro-2-(2-chlorophenoxy)acetamido) benzoic acid) was chosen as a new, potentially selective inhibitor. Goal: Our aim was to elucidate the effect and selectivity of CBA in canine left ventricular cardiomyocytes and to study the expression of TRPM4 in the canine heart. Experiments were carried out in enzymatically isolated canine left ventricular cardiomyocytes. Ionic currents were recorded with an action potential (AP) voltage-clamp technique in whole-cell configuration at 37 ?C. An amount of 10 mM BAPTA was used in the pipette solution to exclude the potential activation of TRPM4 channels. AP was recorded with conventional sharp microelectrodes. CBA was used in 10 ?M concentrations. Expression of TRPM4 protein in the heart was studied by Western blot. TRPM4 protein was expressed in the wall of all four chambers of the canine heart as well as in samples prepared from isolated left ventricular cells. CBA induced an approximately 9% reduction in AP duration measured at 75 and 90% of repolarization and decreased the short-term variability of APD90. Moreover, AP amplitude was increased and the maximal rates of phase 0 and 1 were reduced by the drug. In AP clamp measurements, CBA-sensitive current contained a short, early outward and mainly a long, inward current. Transient outward potassium current (Ito) and late sodium current (INa,L) were reduced by approximately 20 and 47%, respectively, in the presence of CBA, while L-type calcium and inward rectifier potassium currents were not affected. These effects of CBA were largely reversible upon washout. Based on our results, the CBA induced reduction of phase-1 slope and the slight increase of AP amplitude could have been due to the inhibition of Ito. The tendency for AP shortening can be explained by the inhibition of inward currents seen in AP-clamp recordings during the plateau phase. This inward current reduced by CBA is possibly INa,L, therefore, CBA is not entirely selective for TRPM4 channels. As a consequence, similarly to 9-phenanthrol, it cannot be used to test the contribution of TRPM4 channels to cardiac electrophysiology in ventricular cells, or at least caution must be applied.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk CBA TRPM4 cardiac ionic currents cardiac action potentials canine myocytes action potential voltage clamp
Megjelenés:	International Journal Of Molecular Sciences. - 22 : 17 (2021), p. 9499. -
További szerzők:	Hézső Tamás (1993-) (élettanász) Kiss Dénes Zsolt (1995-) (orvos, élettanász) Baranyai Dóra Kovács Zsigmond Máté (1995-) (orvos) Szabó László (1994-) (molekuláris biológus) Magyar János (1961-) (élettanász) Bányász Tamás (1960-) (élettanász) Nánási Péter Pál (1956-) (élettanász) Horváth Balázs (1981-) (élettanász) Gönczi Mónika (1974-) (élettanász) Szentandrássy Norbert (1976-) (élettanász)
Pályázati támogatás:	NKFIH-K115397 Egyéb NKFIH-K138090 Egyéb NKFIH-FK128116 Egyéb GINOP-2.3.2-15-2016-00040 GINOP EFOP-3.6.2-16-2017-00006 EFOP DE-SPACE(TKP-2020-NKA-04) Egyéb EFOP-3.6.3-VEKOP-16-2017-00009 EFOP ÚNKP-20-3 Egyéb ÚNKP-20-2 Egyéb
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001-es BibID:	BIBFORM135271
035-os BibID:	(wos)001670630800001
Első szerző:	Szabó László (molekuláris biológus)
Cím:	The Beneficial Effects of Marine Plant-Derived Compounds on the Musculoskeletal System / Szabó László, Gere Áron, Kovács Zsigmond Máté, Bazsó Tamás, Dienes Beatrix
Dátum:	2026
ISSN:	1661-6596 1422-0067
Megjegyzések:	The skeletal muscle system is particularly susceptible to degenerative and inflammatory processes that threaten mobility, quality of life, and systemic health. Marine plants, including brown, red, and green algae, are valuable yet understudied sources of bioactive compounds with therapeutic potential against skeletal muscle inflammation and degeneration. This narrative review provides the first overview of polyphenols, polysaccharides, carotenoids, and multiminerals derived from marine plants, with a particular focus on their effects on skeletal muscle, bone, and joint tissues. It highlights both the therapeutic potential and the limitations of marine plant-derived bioactive compounds in the musculoskeletal system. The compounds discussed, such as phlorotannins, ulvan, fucoidan, carotenoids, spirulina derivatives, and Aquamin, modulate key signaling pathways, including NF-?B, JAK/STAT3, and the NLRP3 inflammasome. Among these, MAPK emerges as the most consistently affected axis across all compound classes, leading to a reduction in TNF-?, IL-1?, IL-6, and oxidative stress markers. These bioactive compounds have been shown in both in vitro and in vivo models to reduce muscle catabolism, enhance osteoblast differentiation and mineralization, and reduce cartilage inflammation. Despite favorable safety, biocompatibility, and biodegradability profiles, current evidence shows that systemic applications significantly dominate over local delivery, highlighting the untapped potential of localized delivery strategies. Overall, this narrative review underscores the growing importance of marine plant-derived bioactives as promising natural agents for maintaining musculoskeletal integrity and alleviating degenerative disorders.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk marine plant derivatives anti-inflammatory effects musculoskeletal system muscle atrophy osteoarthritis
Megjelenés:	International Journal Of Molecular Sciences. - 27 : 2 (2026), p. 1-21. -
További szerzők:	Gere Áron Kovács Zsigmond Máté (1995-) (orvos) Bazsó Tamás (1974-) (ortopéd sebész) Dienes Beatrix (1972-) (élettanász, molekuláris biológus)
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