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001-es BibID:	BIBFORM124445
035-os BibID:	(WoS)001276129000001
Első szerző:	Kolay, Ankit
Cím:	Immunotherapies: A Treasure Trove of Alzheimer's Disease / Kolay, Ankit; Singh, Neelam; Gupta, Puneet; Shaikh, Ayaz Mukarram; Goel, Radha; Nagpal, Dheeraj; Chitme, Havagiray
Dátum:	2024
ISSN:	1389-2010
Megjegyzések:	Alzheimer's disease (AD) is a progressive neurodegenerative disease that falls under the umbrella of dementia and is characterized by the presence of enormously neurotoxic amyloid-beta (A?) plaques and neurofibrillary tangles (NFTs) of tau protein inside the brain. AD remains an intractable global health challenge with limited therapeutic options. Early diagnosis, enabled by biomarkers and neuroimaging, is pivotal for optimizing treatment outcomes. Immunotherapeutic strategies, including monoclonal antibodies, active vaccination, and passive immunization, have been developed to target hallmark AD pathology, such as amyloid-beta aggregation. Here we summarized the emerging role of immunotherapies in the early stages of AD, shedding light on recent breakthroughs and clinical progress. Challenges, including treatment response variability and safety concerns, are discussed alongside evolving approaches, such as personalized immunotherapy and combinatorial treatments. This concise review underscores the promise of immunotherapies as a transformative approach to AD intervention, offering hope for a brighter future in the quest to combat this devastating neurodegenerative disease.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Dementia immunotherapies amyloid-beta clinical trials neurodegenerative challenges Alzheimer's disease.
Megjelenés:	Current Pharmaceutical Biotechnology. - 26 : 12 (2025), p. 1936-1949. -
További szerzők:	Singh, Neelam Gupta, Puneet Shaikh, Ayaz Mukarram (1991-) (PhD candidate) Goel, Radha Nagpal, Dheeraj Chitme, Havagiray
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM118718
035-os BibID:	(WoS)001177080300001 (Scopus)85187203957
Első szerző:	Singh, Neelam
Cím:	Nanophytosomal gel of Heydotis corymbosa (L.) extract against psoriasis : characterisation, in vitro and in vivo biological activity / Neelam Singh, Ayaz Mukarram Shaikh, Puneet Gupta, Béla Kovács, Mohammed F. Abuzinadah, Aftab Ahmad, Radha Goel, Swapnil Singh, Chaitanya Vinayak
Dátum:	2024
ISSN:	1424-8247
Megjegyzések:	The current study was conducted to examine the possible advantages of Heydotis corymbosa (L.) Lam. extract nanogel as a perspective for enhanced permeation and extended skin deposition in psoriasis-like dermatitis. Optimised nanophytosomes (NPs) were embedded in a pluronic gel base to obtain nanogel and tested ex vivo (skin penetration and dermatokinetics) and in vivo. The optimised NPs had a spherical form and entrapment efficiency of 73.05 ± 1.45% with a nanosized and zeta potential of 86.11 nm and - 10.40 mV, respectively. Structural evaluations confirmed encapsulation of the drug in the NPs. Topical administration of prepared nanogel to a rat model of psoriasis-like dermatitis revealed its specific in vivo anti-psoriatic efficacy in terms of drug activity compared to the control and other formulations. Nanogel had improved skin integrity and downregulation of inflammatory cytokines. These findings suggest that developed phytoconstituent-based nanogel has the potential to alleviate psoriasis-like dermatitis with better skin retention and effectiveness.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Heydotis corymbosa nanogel dermatokinetic psoriasis inflammatory markers skin retention plant derived compounds in vitro and in vivo
Megjelenés:	Pharmaceuticals. - 17 : 2 (2024), p. 1-24. -
További szerzők:	Shaikh, Ayaz Mukarram (1991-) (PhD candidate) Gupta, Puneet Kovács Béla (1963-) (mezőgazdasági kémia, angol szakfordító) Abuzinadah, Mohammed F. Ahmad, Aftab Goel, Radha Singh, Swapnil Vinayak, Chaitanya
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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