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001-es BibID:	BIBFORM127845
035-os BibID:	(Scopus)85206218333 (WoS)001329866500001
Első szerző:	Li, Zhengrui
Cím:	Microbiome's role in musculoskeletal health through the gut-bone axis insights / Zhengrui Li, Qi Wang, Xufeng Huang, Yinteng Wu, Dan Shan
Dátum:	2024
ISSN:	1949-0976 1949-0984
Megjegyzések:	The interplay between the human microbiome and the musculoskeletal system represents a burgeoning field of research with profound implications for understanding and treating musculoskeletal disorders. This review articulates the pivotal role of the microbiome in modulating bone health, highlighting the gut-bone axis as a critical nexus for potential therapeutic intervention. Through a meticulous analysis of recent clinical research, we underscore the microbiome's influence on osteoporosis, sarcopenia, osteoarthritis, and rheumatoid arthritis, delineating both the direct and indirect mechanisms by which microbiota could impact musculoskeletal integrity and function. Our investigation reveals novel insights into the microbiota's contribution to bone density regulation, hormone production, immune modulation, and nutrient absorption, laying the groundwork for innovative microbiome-based strategies in musculoskeletal disease management. Significantly, we identify the challenges hindering the translation of research into clinical practice, including the limitations of current microbial sequencing techniques and the need for standardized methodologies in microbiome studies. Furthermore, we highlight promising directions for future research, particularly in the realm of personalized medicine, where the microbiome's variability offers unique opportunities for tailored treatment approaches. This review sets a new agenda for leveraging gut microbiota in the diagnosis, prevention, and treatment of musculoskeletal conditions, marking a pivotal step toward integrating microbiome science into clinical musculoskeletal care.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk bone health gut-bone axis Microbiome musculoskeletal disease musculoskeletal health
Megjelenés:	Gut Microbes. - 16 : 1 (2024), p. 1-16. -
További szerzők:	Wang, Qi Huang, Xufeng (1997-) (Bioinformatics, Oncology, Dentistry) Wu, Yinteng Shan, Dan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM119625
035-os BibID:	(Scopus)85186334867
Első szerző:	Li, Zhengrui
Cím:	A Mendelian Randomisation Analysis Reveals No Relationship Between Periodontitis and Coronary Atherosclerosis / Zhengrui Li, Qi Wang, Xufeng Huang, Yinteng Wu, Rao Fu, Xutao Wen, Ji'An Liu, Yuanguo Chen, Ying Liu, Ling Zhang
Dátum:	2024
ISSN:	0020-6539
Megjegyzések:	Growing evidence appears to intimate a profound connection between periodontitis and coronary atherosclerosis (CA), yet the existence of a causal relationship remains unclear. Through the implementation of Mendelian randomization analysis, we further evaluated the potential causal link between chronic/acute periodontitis (CP/AP) and CA. Methods: Utilizing genome-wide association study (GWAS) summary statistics, we incorporated periodontitis data derived from European samples (n1 = 198,441; n2 = 195,762) and CA data from 61,194 cases. We conducted a 2 sample, bidirectional Mendelian randomization (MR) analysis using the inverse-variance weighted (IVW) method as the main analytical approach. Supplementary analyses were executed through MR Egger, Weighted median (WM), IVW, Simple mode, and Weighted mode approaches. Results: The IVW analysis revealed no significant causal relationship between CA and periodontitis (CA-CP: OR = 2.110, 95% CI = 0.208-21.317, P = .527; CA-AP: OR = 0.414, 95% CI = 0.051-3.384, P = .644). Similarly, the bidirectional analysis did not identify impact of periodontitis on CA (OR = 1.000, 95% CI = 0.999-1.001, P = .953). The supplementary analyses corroborated these findings. Conclusions: While studies highlighting a correlation between periodontitis and CA, our comprehensive analysis does not corroborate a causal association between periodontitis and CA. Further research is needed to elucidate other potential shared mechanisms and causal evidence between periodontitis and CA.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International Dental Journal. - 74 : 4 (2024), p. 705-712. -
További szerzők:	Wang, Qi Huang, Xufeng (1997-) (Bioinformatics, Oncology, Dentistry) Wu, Yinteng Fu, Rao Wen Xutao Liu, Ji'an Chen, Yuanguo Liu, Ying Zhang, Ling
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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