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001-es BibID:	BIBFORM124893
035-os BibID:	(scopus)85199625554 (wos)001276665500001
Első szerző:	Aradi Zsófia (belgyógyász szakorvos)
Cím:	Polyarthritis in Sjögren's Syndrome : Difficulties in Distinguishing Extraglandular Manifestation and Associated Rheumatoid Arthritis / Aradi Zsófia, Nagy Gábor, Horváth Ildikó Fanny, Antal-Szalmás Péter, Szántó Antónia
Dátum:	2024
ISSN:	2075-4418
Megjegyzések:	Aim of the study was to investigate the demographic data and disease course characteristics of patients with Sjögren's syndrome (SS) and inflammatory joint pain of various origins and to search for factors that might help with the distinction of polyarthritis as an extraglandular manifestation and rheumatoid arthritis as an associated systemic autoimmune disorder. A total of 355 patients were retrospectively analyzed, 128 of whom served as controls (SS-C), while 159 had polyarthritis as an extraglandular symptom of Sjögren's syndrome (SS-pa) and 68 were diagnosed as having associated rheumatoid arthritis (SS-RA). The patients without any inflammatory joint manifestations were significantly older than the SS-pa patients, while, for the SS-RA group, the difference was not significant. The onset of joint pain appeared significantly earlier in the SS-RA patients. Regarding either extraglandular manifestations or associated autoimmune disorders, there were significant differences between the controls and both SS-pa and SS-RA groups, while no significant difference was found between the SS-pa and SS-RA groups. Thus, laboratory and imaging methods should be used to differentiate between the two conditions, but laboratory biomarkers are even more important for early diagnosis. A ROC curve analysis showed an acceptable diagnostic accuracy in differentiating between SS-pa and SS-RA patients using a binary logistic regression model, where highly positive rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) values, kidney involvement, and anti-Ro/SS-A positivity were shown to significantly raise the odds of having RA, whereas anti-La/SS-B positivity seemed to have a protective role, since it significantly decreased the odds of having it. Further biomarkers are needed to better classify SS patient cohorts with inflammatory joint pain of different origins and, consequently, different management requirements.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Sjögren's syndrome associated rheumatoid arthritis polyarthritis extraglandular manifestation
Megjelenés:	Diagnostics. - 14 : 14 (2024), p. 1-12.-
További szerzők:	Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM126755
035-os BibID:	(scopus)85211810776 (wos)001376955900001
Első szerző:	Mezei Kincső (orvos)
Cím:	Obesity : Friend or Foe in Sjögren's Syndrome Patients? / Mezei Kincső, Nagy Laura, Orosz Viktória, Aradi Zsófia, Bói Bernadett, Szántó Antónia
Dátum:	2024
ISSN:	2075-4418
Megjegyzések:	Background/Objectives: In Sjögren's syndrome, exocrine glands are destructed in an autoimmune-mediated process. Obesity is known to influence a wide range of diseases. This study aimed to examine whether obesity has an impact on the disease course of our patients with Sjögren's syndrome. Methods: Out of the regularly followed-up patients, 125 were grouped based on their body mass index (BMI). Below a BMI of 25, they were listed as "non-obese" (n = 45), whereas above a BMI of 25, they were categorized as "obese" (n = 80). Demographic, laboratory, and immunological parameters; Sjögren's syndrome disease activity index; certain extraglandular manifestations; and treatment modalities were compared using biostatistical methods. Results: Among the examined cardiovascular and cerebrovascular co-morbidities, type 2 diabetes and hypertension were significantly more frequent in the obese group. Considering the associated further autoimmune disorders and extraglandular manifestations, in our patients, there were no significant differences between the two groups. Among laboratory parameters, gamma glutamil transferase, alanine transaminase, hemoglobin, hematocrit, lymphocyte rate, triglyceride, and c3 and c4 complement levels were significantly higher in the obese group, while the proportion of rheumatoid factor positivity and the neutrophil granulocyte rate were significantly lower. Immunoglobulin G, A, and M levels did not differ significantly between the two subsets. Obese patients needed steroid therapy significantly less frequently; however, statin therapy was remarkably more frequent in that group. Furthermore, the European League Against Rheumatism (EULAR) Sjögren's syndrome disease activity index (ESSDAI) was significantly lower in the group of overweight patients. Conclusions: Our results suggest that several immunological parameters of obese patients are more favorable compared to those with normal body weight. Behind that, we might suspect either the beneficial effect of statin therapy and/or the obesity paradox.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Sjögren's syndrome obesity statin obesity paradox
Megjelenés:	Diagnostics. - 14 : 23 (2024), p. 1-11. -
További szerzők:	Nagy Laura Orosz Viktória (1988-) (orvos) Aradi Zsófia (1992-) (belgyógyász szakorvos) Bói Bernadett Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
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001-es BibID:	BIBFORM106266
035-os BibID:	(Scopus)85145924688 (WoS)000908868000001
Első szerző:	Módis László (neurológus)
Cím:	Central Nervous System Involvement in Primary Sjögren's Syndrome : Narrative Review of MRI Findings / Módis László V., Aradi Zsófia, Horváth Ildikó Fanny, Bencze János, Papp Tamás, Emri Miklós, Berényi Ervin, Bugán Antal, Szántó Antónia
Dátum:	2023
ISSN:	2075-4418
Megjegyzések:	Central nervous system (CNS) involvement is one of the numerous extraglandular manifestations of primary Sjögren's syndrome (pSS). Moreover, neurological complaints precede the sicca symptoms in 25-60% of the cases. We review the magnetic resonance imaging (MRI) lesions typical for pSS, involving the conventional examination, volumetric and morphometric studies, diffusion tensor imaging (DTI) and resting-state fMRI. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, DTI and resting-state fMRI alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these MRI alterations are expectedly related to them. This relationship is not clearly delineated in conventional MRI studies, but DTI and resting-state fMRI examinations show more convincing correlations. In conclusion, the CNS manifestations of pSS do not follow a certain pattern. As the link between the MRI lesions and clinical manifestations is not well established, more studies involving larger populations should be performed to elucidate the correlations.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Sjögren's syndrome central nervous system magnetic resonance imaging white matter hyperintensities
Megjelenés:	Diagnostics. - 13 : 1 (2023), p. 1-18. -
További szerzők:	Aradi Zsófia (1992-) (belgyógyász szakorvos) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Bencze János (1991-) (orvos) Papp Tamás (1987-) (orvos) Emri Miklós (1962-) (fizikus) Berényi Ervin (1964-) (radiológus) Bugán Antal (1948-) (pszichológus, klinikai szakpszichológus, pszichoterapeuta) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
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