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001-es BibID:BIBFORM130040
035-os BibID:(WoS)001496459600001 (Scopus)105006790506
Első szerző:Aradi Zsófia (belgyógyász szakorvos)
Cím:Additive Value of Rheumatoid Factor Isotypes in Sjögren's Syndrome Patients with Joint Complaints of Different Etiologies : Can Rheumatoid Factor IgA Serve as an Early, Poor Prognostic Biomarker Candidate? / Zsófia Aradi, Bernadett Bói, Gábor Nagy, Péter Antal-Szalmás, Kincső Mezei, Ildikó Fanny Horváth, Antónia Szántó
Dátum:2025
ISSN:1661-6596 1422-0067
Megjegyzések:The aim of the paper was to characterize rheumatoid factor IgA, IgG, and IgM isotypes in patients with Sjögren's syndrome (SS) subsets, based on the absence or presence of joint complaints of different etiologies. In total, 164 SS patients were grouped based on whether they had polyarthritis as an extraglandular manifestation (n = 73, SS+pa), rheumatoid arthritis as an associated autoimmune disorder (n = 46, SS+RA), or Sjögren's syndrome without inflammatory joint pain (n = 45, SS). The highest IgA rheumatoid factor isotype levels were detected in SS patients, whereas the lowest levels were found in the SS+RA group, without a significant difference. Neither IgG nor IgM RF differed significantly between the patient subclasses. In addition to other disease-specific markers, seropositive patients who were seropositive for any RF isotype were significantly more frequently anti-Ro/SS-A and anti-La/SS-B positive and had higher ESSDAI levels. In SS and SS+pa patients, a strong negative correlation was observed between IgA RF and age, whereas a strong positive correlation was found between IgA RF and ESSDAI, RF, IgA, IgG, anti-Ro/SS-A, and anti-La/SS-B levels. High total IgG levels together with high IgA RF levels occurred most frequently in SS patients (p = 0.05), whereas the combination of normal IgG and high IgM RF was significantly more frequent in the SS+RA group. The co-occurrence of high total IgG and normal IgM RF did not differ significantly between the patient subsets; however, this was the combination with the highest sensitivity (94.5%) for SS+pa patients. Based on our findings, rheumatoid factor isotypes have an additive value in the differentiation of non-erosive polyarthritis and erosive rheumatoid arthritis during the disease course of patients with Sjögren's syndrome. All rheumatoid factor isotypes predict a more severe disease course, but IgA RF may serve as a candidate for being an early, poor prognostic factor for SS patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Sjögren's syndrome
polyarthritis
rheumatoid arthritis
rheumatoid factor isotypes
rheumatoid factor
biomarker
Megjelenés:International Journal Of Molecular Sciences. - 26 : 10 (2025), p. 1-13. -
További szerzők:Bói Bernadett Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Mezei Kincső (1995-) (orvos) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
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2.

001-es BibID:BIBFORM124893
035-os BibID:(scopus)85199625554 (wos)001276665500001
Első szerző:Aradi Zsófia (belgyógyász szakorvos)
Cím:Polyarthritis in Sjögren's Syndrome : Difficulties in Distinguishing Extraglandular Manifestation and Associated Rheumatoid Arthritis / Aradi Zsófia, Nagy Gábor, Horváth Ildikó Fanny, Antal-Szalmás Péter, Szántó Antónia
Dátum:2024
ISSN:2075-4418
Megjegyzések:Aim of the study was to investigate the demographic data and disease course characteristics of patients with Sjögren's syndrome (SS) and inflammatory joint pain of various origins and to search for factors that might help with the distinction of polyarthritis as an extraglandular manifestation and rheumatoid arthritis as an associated systemic autoimmune disorder. A total of 355 patients were retrospectively analyzed, 128 of whom served as controls (SS-C), while 159 had polyarthritis as an extraglandular symptom of Sjögren's syndrome (SS-pa) and 68 were diagnosed as having associated rheumatoid arthritis (SS-RA). The patients without any inflammatory joint manifestations were significantly older than the SS-pa patients, while, for the SS-RA group, the difference was not significant. The onset of joint pain appeared significantly earlier in the SS-RA patients. Regarding either extraglandular manifestations or associated autoimmune disorders, there were significant differences between the controls and both SS-pa and SS-RA groups, while no significant difference was found between the SS-pa and SS-RA groups. Thus, laboratory and imaging methods should be used to differentiate between the two conditions, but laboratory biomarkers are even more important for early diagnosis. A ROC curve analysis showed an acceptable diagnostic accuracy in differentiating between SS-pa and SS-RA patients using a binary logistic regression model, where highly positive rheumatoid factor (RF) and anti-cyclic citrullinated peptide (CCP) values, kidney involvement, and anti-Ro/SS-A positivity were shown to significantly raise the odds of having RA, whereas anti-La/SS-B positivity seemed to have a protective role, since it significantly decreased the odds of having it. Further biomarkers are needed to better classify SS patient cohorts with inflammatory joint pain of different origins and, consequently, different management requirements.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Sjögren's syndrome
associated rheumatoid arthritis
polyarthritis
extraglandular manifestation
Megjelenés:Diagnostics. - 14 : 14 (2024), p. 1-12.-
További szerzők:Nagy Gábor (1974-) (laboratóriumi szakorvos, laboratóriumi hematológus és immunológus) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM131929
035-os BibID:(scopus)105008285512 (wos)001509858500001
Első szerző:Módis László (neurológus)
Cím:Unveiling psychobiological correlates in primary Sjögren's syndrome : a machine learning approach to determinants of disease burden / V. Módis László, Matuz András, Aradi Zsófia, Horváth Ildikó Fanny, Szántó Antónia, Bugán Antal
Dátum:2025
ISSN:1664-0640
Megjegyzések:Introduction: Besides primary Sjögren's syndrome (pSS) is generally assessed through biological markers, growing evidence suggests that psychological and social factors?such as anxiety, depression, personality traits, and social support?may also play a role in disease burden. Relative contribution of these biopsychosocial dimensions to disease activity in pSS, however, has not been quantitatively compared. This study aimed to evaluate the predictive weight of different factors in determining both objective and subjective disease burden using machine learning (ML) models. Methods: 117 pSS patients, whose biological (blood cell counts, complement activity, IgG, RF, SSA, SSB), psychological (personality traits, depression, anxiety, basic self-esteem assessed via self-reported questionnaires), and social (socioeconomic status and social support) measures were collected in a composite database. Outcome variables were SSA/SSB autoantibodies and EULAR Sjögren Syndrome Patient Reported Index (ESSPRI), as indicators of biological and perceived disease burden, respectively. Three machine learning algorithms were trained to predict outcome variables, first by each measure category, then on the entire set of predictor variables. Permutation feature importance was used to assess the importance of the predictors. The five most important predictors were selected for all target outcomes. Results: Concerning autoantibodies, the model performed best with biological input only, in the case of ESSPRI, the complete dataset gave the best performance. Trait anxiety was selected as important negative predictor of both autoantibodies. Besides, biological measures (IgG, RF, platelet count) and age were among the five most important features. State anxiety and temperament trait ♭Fatigability' were important positive predictors of ESSPRI, while character trait ♭Pure-hearted conscience', IgG and RF were important negative predictors. Conclusions: Unexpected psychobiological correlations, like trait anxiety and IgG/RF as negative predictors of autoantibodies and ESSPRI, respectively, suggest different (immunobiological and psychosomatic) disease mechanisms and symptom burden. Importance of psychological factors in estimating disease burden may pave the way toward novel, more sensitive diagnostic tools and therapeutic methods and better understanding of pathomechanisms of pSS.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
primary Sjögren's syndrome
machine learning
biopsychosocial model
autoantibodies
symptom burden
psychobiological correlations
temperament and character
state and trait anxiety
Megjelenés:Frontiers in Psychiatry. - 16 (2025), p. 1-11. -
További szerzők:Matuz András Aradi Zsófia (1992-) (belgyógyász szakorvos) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus) Bugán Antal (1948-) (pszichológus, klinikai szakpszichológus, pszichoterapeuta)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM122380
035-os BibID:(Scopus)85194752680 (WOS)001236334900064
Első szerző:Módis László (neurológus)
Cím:Spirituality is associated with immune parameters and disease activity in primary Sjögren's syndrome : a cross-sectional study / László V. Módis, Zsófia Aradi, Ildikó Fanny Horváth, Péter Pikó, Gábor Papp, Mátyás Osváth, Antónia Szántó, Antal Bugán
Dátum:2024
ISSN:2045-2322
Megjegyzések:The role of spirituality in health and disease is a complex and emerging area of research. Incorporating spirituality into the bio-psycho-social model of health and disease leading to the bio-psycho-social-spiritual model provides a more comprehensive framework. In this context, chronic disorders like primary Sjögren's syndrome (pSS) are of interest due to their intricate interactions between biological, psychological, and spiritual factors. This study explored the relationship between spirituality, immune parameters, and disease activity in pSS patients. Data from 108 patients were analyzed, including self-assessed spirituality (answering to direct questions and completing the Spiritual Transcendence Scale), immunological parameters and disease activity scores. The findings revealed several associations. Individuals with spiritual attitudes or engaged in regular prayer/meditation showed lower serum levels of autoantibodies specific to pSS and lower disease activity scores. Spiritual engagement was also linked to decreased perceived skin and tracheal dryness, suggesting potential benefits for physical symptoms. These findings suggest that spirituality may play a significant role in modulating immune responses and disease activity in pSS patients. The study underscores the importance of considering spirituality as an integral part of the holistic approach to health and disease, further expanding the understanding of the interconnectedness of biological, psychological, and spiritual dimensions. ? The Author(s) 2024.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Adult
Aged
Autoantibodies
Cross-Sectional Studies
Female
Humans
Male
Middle Aged
Sjogren's Syndrome
Spirituality
Megjelenés:Scientific Reports. - 14 : 1 (2024), p. 1-9. -
További szerzők:Aradi Zsófia (1992-) (belgyógyász szakorvos) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Pikó Péter (1987-) (biológus) Papp Gábor Osváth Mátyás (1996-) (Egészségpszichológus) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus) Bugán Antal (1948-) (pszichológus, klinikai szakpszichológus, pszichoterapeuta)
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Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM106266
035-os BibID:(Scopus)85145924688 (WoS)000908868000001
Első szerző:Módis László (neurológus)
Cím:Central Nervous System Involvement in Primary Sjögren's Syndrome : Narrative Review of MRI Findings / Módis László V., Aradi Zsófia, Horváth Ildikó Fanny, Bencze János, Papp Tamás, Emri Miklós, Berényi Ervin, Bugán Antal, Szántó Antónia
Dátum:2023
ISSN:2075-4418
Megjegyzések:Central nervous system (CNS) involvement is one of the numerous extraglandular manifestations of primary Sjögren's syndrome (pSS). Moreover, neurological complaints precede the sicca symptoms in 25-60% of the cases. We review the magnetic resonance imaging (MRI) lesions typical for pSS, involving the conventional examination, volumetric and morphometric studies, diffusion tensor imaging (DTI) and resting-state fMRI. The most common radiological lesions in pSS are white matter hyperintensities (WMH), scattered alterations hyperlucent on T2 and FLAIR sequences, typically located periventricularly and subcortically. Cortical atrophy and ventricular dilatation can also occur in pSS. Whilst these conditions are thought to be more common in pSS than healthy controls, DTI and resting-state fMRI alterations demonstrate evident microstructural changes in pSS. As pSS is often accompanied by cognitive symptoms, these MRI alterations are expectedly related to them. This relationship is not clearly delineated in conventional MRI studies, but DTI and resting-state fMRI examinations show more convincing correlations. In conclusion, the CNS manifestations of pSS do not follow a certain pattern. As the link between the MRI lesions and clinical manifestations is not well established, more studies involving larger populations should be performed to elucidate the correlations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Sjögren's syndrome
central nervous system
magnetic resonance imaging
white matter hyperintensities
Megjelenés:Diagnostics. - 13 : 1 (2023), p. 1-18. -
További szerzők:Aradi Zsófia (1992-) (belgyógyász szakorvos) Horváth Ildikó Fanny (1980-) (belgyógyász, allergológus, klinikai immunológus) Bencze János (1991-) (orvos) Papp Tamás (1987-) (orvos) Emri Miklós (1962-) (fizikus) Berényi Ervin (1964-) (radiológus) Bugán Antal (1948-) (pszichológus, klinikai szakpszichológus, pszichoterapeuta) Szántó Antónia (1977-) (belgyógyász, allergológus és klinikai immunológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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