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001-es BibID:	BIBFORM120986
035-os BibID:	(Scopus)85191425001 (WoS)001210889800001
Első szerző:	Bodnár Krisztina (biotechnológus)
Cím:	Recent Approaches for the Topical Treatment of Psoriasis Using Nanoparticles / Krisztina Bodnár, Pálma Fehér, Zoltán Ujhelyi, Ildikó Bácskay, Liza Józsa
Dátum:	2024
ISSN:	1999-4923
Megjegyzések:	Psoriasis (PSO) is a chronic autoimmune skin condition characterized by the rapid and excessive growth of skin cells, which leads to the formation of thick, red, and scaly patches on the surface of the skin. These patches can be itchy and painful, and they may cause discomfort for patients affected by this condition. Therapies for psoriasis aim to alleviate symptoms, reduce inflammation, and slow down the excessive skin cell growth. Conventional topical treatment options are non-specific, have low efficacy and are associated with adverse effects, which is why researchers are investigating different delivery mechanisms. A novel approach to drug delivery using nanoparticles (NPs) shows promise in reducing toxicity and improving therapeutic efficacy. The unique properties of NPs, such as their small size and large surface area, make them attractive for targeted drug delivery, enhanced drug stability, and controlled release. In the context of PSO, NPs can be designed to deliver active ingredients with anti-inflammatory effect, immunosuppressants, or other therapeutic compounds directly to affected skin areas. These novel formulations offer improved access to the epidermis and facilitate better absorption, thus enhancing the therapeutic efficacy of conventional anti-psoriatic drugs. NPs increase the surface-to-volume ratio, resulting in enhanced penetration through the skin, including intracellular, intercellular, and trans-appendage routes. The present review aims to discuss the latest approaches for the topical therapy of PSO using NPs. It is intended to summarize the results of the in vitro and in vivo examinations carried out in the last few years regarding the effectiveness and safety of nanoparticles.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk psoriasis nanoparticles topical therapies novel delivery systems nanocarriers
Megjelenés:	Pharmaceutics. - 16 : 4 (2024), p. 1-44. -
További szerzők:	Fehér Pálma (1976-) (gyógyszerész) Ujhelyi Zoltán (1984-) (gyógyszerész) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Józsa Liza (1994-) (gyógyszerész)
Pályázati támogatás:	GINOP-2.3.1-20-2020-00004 GINOP GINOP-2.3.4-15-2020-00008 GINOP 2022-1.2.2-TÉT-IPARI-UZ-2022-00006 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM114390
035-os BibID:	(cikkazonosító)2054 (Scopus)85168867376
Első szerző:	Frei Gréta
Cím:	In Vitro and In Vivo Efficacy of Topical Dosage Forms Containing Self-Nanoemulsifying Drug Delivery System Loaded with Curcumin / Gréta Frei, Ádám Haimhoffer, Enikő Csapó, Krisztina Bodnár, Gábor Vasvári, Dániel Nemes, István Lekli, Alexandra Gyöngyösi, Ildikó Bácskay, Pálma Fehér, Liza Józsa
Dátum:	2023
ISSN:	1999-4923
Megjegyzések:	The external use of curcumin is rare, although it can be a valuable active ingredient in the treatment of certain inflammatory diseases. The aim of our experimental work was to formulate topical dosage forms containing curcumin for the treatment of atopic dermatitis. Curcumin has extremely poor solubility and bioavailability, so we have tried to increase it with the usage of selfemulsifying drug delivery systems. Creams and gels were formulated using penetration-enhancing surfactants and gelling agents. The release of the drug from the vehicle and its penetration through the membrane were determined using a Franz diffusion cell. An MTT cytotoxicity and in vitro antioxidant assays were performed on HaCaT cell line. The in vivo anti-inflammatory effect of the preparations was tested by measuring rat paw edema. In addition, we examined the degree of inflammation induced by UV radiation after pretreatment with the cream and the gel on rats. For the gels containing SNEDDS, the highest penetration was measured after half an hour, while for the cream, it took one hour to reach the maximum concentration. The gel containing Pemulen TR-1 showed the highest drug release. It was determined that the curcumin-containing preparations can be safely applied on the skin and have antioxidant effects. The animal experiments have proven the effectiveness of curcumin-containing topical preparations
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk curcumin self-nanoemulsifying drug delivery systems drug delivery anti-inflammatory effect
Megjelenés:	Pharmaceutics. - 15 : 8 (2023), p. 1-8. -
További szerzők:	Haimhoffer Ádám (1994-) (gyógyszerész) Csapó Enikő Bodnár Krisztina (1999-) (biotechnológus) Vasvári Gábor (1990-) (gyógyszerész, gyógyszertechnológus) Nemes Dániel (1993-) (gyógyszerész) Lekli István (1981-) (gyógyszerész) Gyöngyösi Alexandra (1990-) (táplálkozástudományi szakember) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Fehér Pálma (1976-) (gyógyszerész) Józsa Liza (1994-) (gyógyszerész)
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