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001-es BibID:	BIBFORM114420
035-os BibID:	(WoS)001079872300001 (Scopus)85172208850
Első szerző:	Alaya, Amina (PhD student)
Cím:	Phytoconstituent Profiles Associated with Relevant Antioxidant Potential and Variable Nutritive Effects of the Olive, Sweet Almond, and Black Mulberry Gemmotherapy Extracts / Amina Aleya, Emőke Mihok, Bence Pecsenye, Maria Jolji, Attila Kertész, Péter Bársony, Szabolcs Vígh, Zoltán Cziaky, Anna-Beáta Máthé, Ramona Flavia Burtescu, Neli-Kinga Oláh, Andreea-Adriana Neamtu, Violeta Turcus, Endre Máthé
Dátum:	2023
ISSN:	2076-3921
Megjegyzések:	The extracts of whole plants or specific organs from different plant species are gaining increasing attention for their phytotherapy applications. Accordingly, we prepared standardized gemmotherapy extracts (GTEs) from young shoots/buds of olive (Olea europaea), sweet almond (Prunus amygdalus), and black mulberry (Morus nigra), and analyzed the corresponding phytonutrient profiles. We identified 42, 103, and 109 phytonutrients in the olive, almond, and black mulberry GTEs, respectively, containing amino acids, vitamins, polyphenols, flavonoids, coumarins, alkaloids, iridoids, carboxylic acids, lignans, terpenoids, and others. In order to assess the physiological effects generated by the GTEs, we developed a translational nutrition model based on Drosophila melanogaster and Cyprinus carpio. The results indicate that GTEs could influence, to a variable extent, viability and ATP synthesis, even though both are dependent on the specific carbohydrate load of the applied diet and the amino acid and polyphenol pools provided by the GTEs. It seems, therefore, likely that the complex chemical composition of the GTEs offers nutritional properties that cannot be separated from the health-promoting mechanisms that ultimately increase viability and survival. Such an approach sets the paves the way for the nutritional genomic descriptions regarding GTE-associated health-promoting effects.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Olea europaea Prunus amygdalus Morus nigra Drosophila melanogaster Cyprinus carpio gemmotherapy extract antihyperglycemic effect essential amino acid tryptophane
Megjelenés:	Antioxidants. - 12 : 9 (2023), p. 1-36. -
További szerzők:	Mihok Emőke (1989-) (élelmiszermérnök) Pecsenye Bence (1992-) (vegyészmérnök, vegyész analitikus) Jolji, Maria (1991-) (Phd hallgató) Kertész Attila (1988-) (agrármérnök) Bársony Péter (1975-) (agrármérnök) Vigh Szabolcs (1981-) (élelmiszer-minőségbiztosító agrármérnök) Cziáky Zoltán Máthé Anna Beáta (1995-) (egészségpszichológus) Burtescu, Ramona Flavia Oláh Neli Kinga (1973-) (gyógyszerész) Neamtu, Andreea-Adriana Turcuş, Violeta Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus)
Pályázati támogatás:	EFOP-3.6.3-VEKOP-16-2017-00008 EFOP 2018-2.1.3-EUREKA-2018-00004 Egyéb
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001-es BibID:	BIBFORM134043
Első szerző:	Chise, Elisabeta
Cím:	Gemmotherapy extracts with quercetin and its derivatives / Elisabeta Chise, Neli-Kinga Olah, Ramona Flavia Burtescu, Daniela Hanganu, Simona Mirel, Adriana Daraban, Ioana Hepcal Cuc, Maria Jolji, Melinda Héjja, Viviane B. Bota, Endre Máthé, Violeta Turcus
Dátum:	2025
ISSN:	1584-2363 1842-7863
Megjegyzések:	Quercetin is one of the most common polyphenol worldwide, named after the oak forest - quercetum. It is considered one of the most powerful antioxidants due to its five phenolic groups, respectively, the ?-pyrone cycle. This flavonoid and its glycosylated derivatives, such as rutoside, hyperoside, quercitrin, and iso-quercitrin, are also present in the extracts obtained from the buds and young shoots of different species, extracts that are therapeutic tools for the new branch of phytotherapy named gemmotherapy or meristem-therapy. In the pandemic context the quercetin and its derivatives were successfully used to improve the side/late effects of SARS-CoV-2 infection. Our study involved the extracts from buds of hazel (Corylus avellana), sweet chestnut (Castanea sativa), and the young shoots from honeysuckle (Lonicera nigra), dog-rose (Rosa canina), lingonberry (Vaccinium vitis-idaea), and European blackberry (Rubus fruticosus). Quercetin and its derivatives were identified and quantified by the HPLC method. The total flavonoids were determined by the spectral method. The highest quercetin-containing gemmotherapy extracts were obtained from the sweet chestnut and hazel buds, respectively, from Honeysuckle and Lingonberry young shoots. Due to their rich quercetin content, these extracts were proposed for the complementary treatment of SARS-CoV-2 infections and post-COVID symptoms.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk quercetin gemmotherapy extracts Hazel buds Sweet chestnut buds Honeysuckle young shoots Lingonberry young shoots SarsCov-2 infection
Megjelenés:	Studia Universitatis "Vasile Goldis". Seria Ştiinţele Vieţii. - 33 : 3 (2025), p. 109-115. -
További szerzők:	Oláh Neli Kinga (1973-) (gyógyszerész) Burtescu, Ramona Flavia Hanganu, Daniela Mirel, Simona Daraban, Adriana Hepcal Cuc, Ioana Marinela Jolji, Maria (1991-) (Phd hallgató) Héjja Melinda (1997-) (élelmiszeripari mérnök) Bota, Viviane Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus) Turcuş, Violeta
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001-es BibID:	BIBFORM119131
035-os BibID:	(WoS)001168290400001 (Scopus)85185969878
Első szerző:	Héjja Melinda (élelmiszeripari mérnök)
Cím:	Specific Antimicrobial Activities Revealed by Comparative Evaluation of Selected Gemmotherapy Extracts / Melinda Héjja, Emőke Mihok, Amina Alaya, Maria Jolji, Éva György, Noemi Meszaros, Violeta Turcus, Neli Kinga Oláh, Endre Máthé
Dátum:	2024
ISSN:	2079-6382
Megjegyzések:	Nowadays, unprecedented health challenges are urging novel solutions to address antimicrobial resistance as multidrug-resistant strains of bacteria, yeasts and moulds are emerging. Such microorganisms can cause food and feed spoilage, food poisoning and even more severe diseases, resulting in human death. In order to overcome this phenomenon, it is essential to identify novel antimicrobials that are naturally occurring, biologically effective and increasingly safe for human use. The development of gemmotherapy extracts (GTEs) using plant parts such as buds and young shoots has emerged as a novel approach to treat/prevent human conditions due to their associated antidiabetic, anti-inflammatory and/or antimicrobial properties that all require careful evaluations. Seven GTEs obtained from plant species like the olive (Olea europaea L.), almond (Prunus amygdalus L.), black mulberry (Morus nigra L.), walnut (Juglans regia L.), blackberry (Rubus fruticosus L.), blackcurrant (Ribes nigrum L.) and bilberry (Vaccinium myrtillus L.) were tested for their antimicrobial efficiency via agar diffusion and microbroth dilution methods. The antimicrobial activity was assessed for eight bacterial (Bacillus cereus, Staphylococcus aureus, Salmonella enterica subsp. enterica, Proteus vulgaris, Enterococcus faecalis, Escherichia coli, Pseudomonas aeruginosa and Listeria monocytogenes), five moulds (Aspergillus flavus, Aspergillus niger, Aspergillus ochraceus, Penicillium citrinum, Penicillium expansum) and one yeast strain (Saccharomyces cerevisiae). The agar diffusion method revealed the blackberry GTE as the most effective since it inhibited the growth of three bacterial, four moulds and one yeast species, having considered the total number of affected microorganism species. Next to the blackberry, the olive GTE appeared to be the second most efficient, suppressing five bacterial strains but no moulds or yeasts. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were then determined for each GTE and the microorganisms tested. Noticeably, the olive GTE appeared to feature the strongest bacteriostatic and bactericidal outcome, displaying specificity for S. aureus, E. faecalis and L. monocytogenes. The other GTEs, such as blueberry, walnut, black mulberry and almond (the list indicates relative strength), were more effective at suppressing microbial growth than inducing microbial death. However, some species specificities were also evident, while the blackcurrant GTE had no significant antimicrobial activity. Having seen the antimicrobial properties of the analysed GTEs, especially the olive and black mulberry GTEs, these could be envisioned as potential antimicrobials that might enhance antibiotic therapies efficiency, while the blackberry GTE would act as an antifungal agent. Some of the GTE mixtures analysed have shown interesting antimicrobial synergies, and all the antimicrobial effects observed argue for extending these studies to include pathological microorganisms.
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk gemmotherapy extracts antimicrobial activity antifungal activity Morus nigra Juglansregia Prunus amygdalus Olea europaea Ribes nigrum Rubus fruticosus Vaccinium myrtillus
Megjelenés:	Antibiotics-Basel. - 13 : 2 (2024), p. 1-31. -
További szerzők:	Mihok Emőke (1989-) (élelmiszermérnök) Alaya, Amina (1992-) (PhD student) Jolji, Maria (1991-) (Phd hallgató) György Éva (1973-) (mikrobiológus) Mészáros Noémi Turcuş, Violeta Oláh Neli Kinga (1973-) (gyógyszerész) Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus)
Pályázati támogatás:	ÚNKP-23-3 Egyéb
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001-es BibID:	BIBFORM124653
Első szerző:	Oláh Neli Kinga (gyógyszerész)
Cím:	Quercetin and rutoside content of some Betula Sp. buds gemmotherapy extracts, from mountain regions / Neli-Kinga Olah, Viviane Beatrice Bota, Ramona Flavia Burtescu, Elisabeta Chișe, Timea Bab, Daniela Hanganu, Simona Mirel, Maria Jolji, Melinda Héjja, Endre Máthé, Violeta Turcuș
Dátum:	2022
ISSN:	2360-6215
Tárgyszavak:	Agrártudományok Élelmiszertudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Quercetin rutoside gemmotherapy HPLC white birch buds silver birch buds SarsCov-2 infection
Megjelenés:	Journal of Montology. - 17 (2022), p. 1-7. -
További szerzők:	Bota, Viviane Burtescu, Ramona Flavia Chise, Elisabeta Bab, Timea Hanganu, Daniela Mirel, Simona Jolji, Maria (1991-) (Phd hallgató) Héjja Melinda (1997-) (élelmiszeripari mérnök) Máthé Endre (1964-) (genetikus, molekuláris sejtbiológus) Turcuş, Violeta
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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