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001-es BibID:	BIBFORM134322
035-os BibID:	(Scopus)105025935057 (WoS)001646473900001
Első szerző:	Bertalan Petra Magdolna (klinikai laboratóriumi kutató, PhD hallgató)
Cím:	Comprehensive Insights into Obesity and Type 2 Diabetes from Protein Network, Canonical Pathway, Phosphorylation, and Antimicrobial Peptide Signatures of Human Serum / Bertalan Petra Magdolna, Erdenetsetseg Nokhoijav, Pap Ádám, George C. Neagu, Káplár Miklós, Darula Zsuzsanna, Kalló Gergő, Prókai László, Csősz Éva
Dátum:	2025
Megjegyzések:	Background: Obesity is a major risk factor for type 2 diabetes (T2D), however, the molecu-lar links between these conditions remain incompletely understood. Methods: We per-formed an integrative serum proteomics study on samples from 135 individuals (healthy controls, patients with obesity, and/or T2D) using both data-independent (DIA) and da-ta-dependent (DDA) liquid chromatography-mass spectrometry approaches, comple-mented by phosphopeptide enrichment, kinase activity prediction, network and pathway analyses to get more information on the different proteoforms involved in the pathophysi-ology of the diseases. Results: We identified 235 serum proteins, including 13 differential-ly abundant proteins (DAPs) between groups. Both obesity and T2D were characterized by activation of complement and coagulation cascades and alterations in lipid metabolism. Ingenuity Pathway Analysis? (IPA) revealed shared canonical pathways, while phos-phorylation-based regulation differentiated the two conditions. Elevated hemopexin (HPX), vitronectin (VTN), kininogen-1 (KNG1), and SERPINF1, along with decreased adi-ponectin (ADIPOQ) and apolipoprotein D (APOD), indicated a pro-inflammatory, pro-coagulant serum profile. Network analyses of antimicrobial and immunomodulatory peptides (AMPs) revealed strong overlaps between immune regulation and lipid metabo-lism. Phosphoproteomics and kinase prediction highlighted altered CK2 and AGC kinase activities in obesity, suggesting signaling-level modulation. Conclusion: Our comprehen-sive proteomic and phosphoproteomic profiling reveals overlapping yet distinct molecu-lar signatures in obesity and T2D, emphasizing inflammation, complement activation, and phosphorylation-driven signaling as central mechanisms potentially contributing to disease progression and therapeutic targeting.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk obesity type 2 diabetes mass spectrometry phosphoproteomics network analysis AMP
Megjelenés:	Proteomes. - 13 : 4 (2025), p. 1-26. -
További szerzők:	Nokhoijav, Erdenetsetseg (1987-) (kutatóorvos) Pap Ádám Neagu, George C. Káplár Miklós (1965-) (belgyógyász, diabetológus) Darula Zsuzsanna Kalló Gergő (1989-) (molekuláris biológus) Prokai László Csősz Éva (1977-) (biokémikus, molekuláris biológus)
Pályázati támogatás:	GINOP-2.3.3-15-2016-00020 GINOP NKFIH FK134605 Egyéb NKFIH 2022-2.1.1-NL-2022-00005 Egyéb EU Horizont 2020 - 739593 Egyéb Tempus Közalapítvány Stipendium Hungaricum 2019 Egyéb KIM NKFIA TKP-2021-EGA-05 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM114402
035-os BibID:	(scopus)85170347560 (wos)001061114800001
Első szerző:	Kalló Gergő (molekuláris biológus)
Cím:	Salivary Chemical Barrier Proteins in Oral Squamous Cell Carcinoma-Alterations in the Defense Mechanism of the Oral Cavity / Kalló Gergő, Bertalan Petra Magdolna, Márton Ildikó, Kiss Csongor, Csősz Éva
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Oral squamous cell carcinoma (OSCC) is one of the most frequent types of head and neck cancer. Despite the genetic and environmental risk factors, OSCC is also associated with microbial infections and/or dysbiosis. The secreted saliva serves as the chemical barrier of the oral cavity and, since OSCC can alter the protein composition of saliva, our aim was to analyze the effect of OSCC on the salivary chemical barrier proteins. Publicly available datasets regarding the analysis of salivary proteins from patients with OSCC and controls were collected and examined in order to identify differentially expressed chemical barrier proteins. Network analysis and gene ontology (GO) classification of the differentially expressed chemical barrier proteins were performed as well. One hundred and twenty-seven proteins showing different expression pattern between the OSCC and control groups were found. Protein?protein interaction networks of up- and down-regulated proteins were constructed and analyzed. The main hub proteins (IL-6, IL-1B, IL-8, TNF, APOA1, APOA2, APOB, APOC3, APOE, and HP) were identified and the enriched GO terms were examined. Our study highlighted the importance of the chemical barrier of saliva in the development of OSCC.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk oral squamous cell carcinoma OSCC antimicrobial and immunomodulatory proteins AMP Saliva Chemical barrier
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 17 (2023), p. 1-20. -
További szerzők:	Bertalan Petra Magdolna (1996-) (klinikai laboratóriumi kutató, PhD hallgató) Márton Ildikó (1954-) (fogszakorvos) Kiss Csongor (1956-) (hematológus, onkológus) Csősz Éva (1977-) (biokémikus, molekuláris biológus)
Pályázati támogatás:	GINOP-2.3.3-15-2016-00020 GINOP NKFIH K143021 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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