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001-es BibID:	BIBFORM133496
035-os BibID:	(scopus)105021809472 (wos)001614560900001
Első szerző:	Kozma Barbara (szülész-nőgyógyász)
Cím:	Hungarian Validation of the Pelvic Floor Distress Inventory - 20(PFDI-20) Questionnaire and the Pelvic Floor Impact Questionnaire - 7(PFIQ-7) / Barbara Kozma, Bence Kozma, Peter Takacs, Dávid Rátonyi, Nelli Farkas, Attila G. Sipos, Bálint Farkas
Dátum:	2025
ISSN:	0937-3462 1433-3023
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	International urogynecology journal. - [Epub ahead of print] (2025). -
További szerzők:	Kozma Bence (1982-) (szülész-nőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász) Rátonyi Dávid (1996-) (Szülész-nőgyógyász) Farkas Nelli Sipos Attila Gergely (1990-) (szülész-nőgyógyász) Farkas Bálint
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001-es BibID:	BIBFORM134626
Első szerző:	Kozma Bence (szülész-nőgyógyász)
Cím:	Improving Vaginal Health With a Zinc-Containing Vaginal Hydrogel : a Prospective Cohort Study / Kozma Bence, Rátonyi Dávid, Kozma Barbara, Takács Péter
Dátum:	2025
ISSN:	0937-3462
Megjegyzések:	Introduction: A variety of vulvovaginal symptoms can affect up to 39% of women. These symptoms have a significant impact on quality of life and are often associated with an imbalance in the vaginal microbiota. In the first line of treatment for vaginal symptoms, various topical preparations, especially ointments, are of particular importance. However, adherence to these products is generally low. It is, therefore, important to develop and test new products with excipients that better meet patients' expectations. Objective: We hypothesize that the zinc-containing hydrogel, previously shown to be effective in alleviating the symptoms of GSM, may also be therapeutically effective in alleviating the vulvovaginal symptoms caused by other etiologies. Methods: A prospective cohort study was performed with the enrollment of thirty-seven women with different vulvovaginal symptoms (itching, burning, irritation, pain, dryness, discharge, and odor). The Institutional Research Council approved the study, and all participants provided written informed consent. Women were asked to use the vaginal gel daily for 2 weeks and twice per week thereafter to complete the 12 weeks study period. Assessments were performed at the time of recruitment and week 12. The severity of vulvovaginal symptoms, including vaginal discharge, odor, itching, pain, dysuria, skin irritation, burning, and dyspareunia, was recorded using the Vulvovaginal Symptom Questionnaire (VSQ-21). Vaginal Health Index (VHI) is a clinical evaluation to assess vaginal health by scoring: elasticity, fluid secretion, pH, epithelial mucosa (integrity), and moisture components. Following the assessment of symptoms, the cervicovaginal lavage (CVL) sample was collected for zinc easurement, and then the zinc level in the CVL was measured by inductively coupled plasma atomic emission spectroscopy (ICP-OES). Results: We found significant improvements in symptoms, including reductions in vaginal discharge, itching, and burning, as measured by VSQ-21, with scores decreasing from 10.78 ? 3.66 at baseline to 3.17 ? 4.16 at week 12 (p < 0.01). VHI scores improved significantly from 20.78 ? 1.74 at baseline to 23.64 ? 2.59 at week 12 (p < 0.01). CVL zinc levels decreased from 110 ? 102 ?g/L at baseline to 62 ? 48 ?g/L at week 4 (p < 0.01), increased to 80 ? 55 ?g/L at week 8 (p = 0.04), and reached 99 ? 92 ?g/L at week 12 (NS). Correlation analysis showed an inverse relationship between baseline CVL zinc levels and VSQ-21 scores (r = -0.3586, p = 0.034), while no significant correlation was observed with VHI scores (r = -0.0187, p = 0.9545). Vaginal pH decreased significantly from 4.03 ? 0.42 to 3.71 ? 0.48 (p < 0.01). Conclusions: This study demonstrates that the zinc-containing hydroxyethyl cellulose-based vaginal hydrogel significantly improves vaginal health by alleviating different vulvovaginal symptoms. Its formulation provides a safe, patient-friendly alternative to oral therapies with no systemic side effects. The gel addresses symptomatic relief and long-term microbiota support by potentially enhancing Lactobacillus growth and maintaining an optimal acidic pH. These findings suggest that it could serve as a potential first-line treatment or as a complementary element of therapy for a variety of vulvovaginal symptoms.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	International Urogynecology Journal. - 36 : Suppl. 1 (2025), p. S182-S183. -
További szerzők:	Rátonyi Dávid (1996-) (Szülész-nőgyógyász) Kozma Barbara (1997-) (szülész-nőgyógyász) Takács Péter (1968-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM125697
Első szerző:	Takács Péter (szülész-nőgyógyász)
Cím:	Biomechanical Integrity Score of the Female Pelvic Floor for Stress Urinary Incontinence / Takacs Péter, Rátonyi Dávid, Koroknai Erzsébet, Pákozdy Krisztina, Sipos Attila Gergely, Van Raalte Heather, Lucente Vincent, Egorov Vladimir, Krasznai Zoárd Tibor, Kozma Bence
Dátum:	2024
ISSN:	0937-3462
Megjegyzések:	Introduction: Urinary incontinence (UI) is a prevalent condition, affecting more than 1 in 3 women at some point in their lives. Stress urinary incontinence (SUI) occurs when unintended urine leakage occurs during coughing, sneezing, or physical exertion. SUI is the most common type overall. Even though UI is widespread, it often goes unnoticed and unreported, with fewer than 40% of affected women seeking medical attention for this issue. It is, therefore, important for healthcare providers to accurately screen for and diagnose SUI. The Vaginal Tactile Imager (VTI) was developed to provide a biomechanical mapping of the pelvic floor with a vaginal probe. A set of new clinical markers/parameters has been proposed for the biomechanical characterization of pelvic floor conditions. This set included 52 parameters automatically calculated as a result of completing eight examination procedures (tests). Biomechanical Integrity score (BI-score) for pelvic organ prolapse (POP) was proposed. In order to make biomechanical mapping in urogynecology more accessible and valuable, further work is required on developing a shorter list of easily understandable and practical biomechanical parameters for SUI characterization. Objective: This study aims to develop and validate a new integral parameter, the BI-score of the female pelvic floor for SUI conditions. Methods: A total of 130 subjects with normal and SUI conditions were included in the observational cohort study; 70 subjects had normal pelvic floor conditions, and 60 subjects had SUI. VTI was used to acquire and automatically calculate 52 biomechanical parameters for eight VTI test procedures (probe insertion, elevation, rotation, Valsalva maneuver, voluntary muscle contractions in two planes, relaxation, and reflex contraction). Statistical methods were applied (t-test, correlation) to identify the VTI parameters sensitive to the pelvic SUI conditions. Results: 27 parameters were identified as statistically sensitive to the SUI development. They were subdivided into five groups to characterize (1) tissue elasticity, (2) pelvic support, (3) pelvic muscle contraction, (4) involuntary muscle relaxation, and (5) pelvic muscle mobility. Every parameter was transformed to its standard deviation units using the dataset for normal pelvic conditions, similar to the T-score for bone density. Linear combinations with specified weights led to the composition of five component parameters for groups (1)-(5) and to the BI-score in standard deviation units. The p-value for the BI-score has p=4.0?10-28 for SUI versus normal conditions. Conclusions: Based on the analysis conveyed, five components are vital for biomechanical characterizing the pelvic floor. All these components contribute to the integral parameter of the BI-score. Objectively measurable transformations of the pelvic tissues, support structures, and functions under different diseased conditions may be studied with the BI-score in future research and practical applications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	International Urogynecology Journal. - 35 : Suppl. 1 (2024), p. S208-S209. -
További szerzők:	Rátonyi Dávid (1996-) (Szülész-nőgyógyász) Koroknai Erzsébet (1987-) (szülész-nőgyógyász) Pákozdy Krisztina (1991-) (szülész-nőgyógyász) Sipos Attila Gergely (1990-) (szülész-nőgyógyász) van Raalte, Heather Lucente, Vincent Egorov, Vladimir Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
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001-es BibID:	BIBFORM121145
035-os BibID:	(Scopus)85192857714 (WoS)001220949800001
Első szerző:	Takács Péter (szülész-nőgyógyász)
Cím:	Biomechanical Integrity Score of the Female Pelvic Floor for Stress Urinary Incontinence / Takacs Peter, Rátonyi Dávid, Koroknai Erzsébet, van Raalte Heather, Lucente Vincent, Egorov Vladimir, Krasznai Zoard Tibor, Kozma Bence
Dátum:	2024
ISSN:	0937-3462
Megjegyzések:	Introduction and hypothesis: This study is aimed at developing and validating a new integral parameter, the Biomechanical Integrity score (BI-score) of the female pelvic floor for stress urinary incontinence conditions. Methods: A total of 130 subjects were included in the observational cohort study; 70 subjects had normal pelvic floor conditions, and 60 subjects had stress urinary incontinence (SUI). A Vaginal Tactile Imager (VTI) was used to acquire and automatically calculate 52 biomechanical parameters for eight VTI test procedures (probe insertion, elevation, rotation, Valsalva maneuver, voluntary muscle contractions in two planes, relaxation, and reflex contraction). Statistical methods were applied (t test, correlation) to identify the VTI parameters sensitive to the pelvic SUI conditions. Results: Twenty-seven parameters were identified as statistically sensitive to SUI development. They were subdivided into five groups to characterize tissue elasticity (group 1), pelvic support (group 2), pelvic muscle contraction (group 3), involuntary muscle relaxation (group 4), and pelvic muscle mobility (group 5). Every parameter was transformed to its standard deviation units using the dataset for normal pelvic conditions, similar to the T-score for bone density. Linear combinations with specified weights led to the composition of five component parameters for groups 1?5 and to the BI-score in standard deviation units. The p value for the BI-score has p = 4.0 ? 10?28 for SUI versus normal conditions. Conclusions: Quantitative transformations of the pelvic tissues, support structures, and functions under diseased conditions may be studied with the SUI BI-score in future research and clinical applications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Stress urinary incontinence Tissue elasticity Pelvic support Pelvic muscle strength Muscle mobility Biomechanical Integrity score
Megjelenés:	International Urogynecology Journal. - 35 : 6 (2024), p. 1245-1253. -
További szerzők:	Rátonyi Dávid (1996-) (Szülész-nőgyógyász) Koroknai Erzsébet (1987-) (szülész-nőgyógyász) van Raalte, Heather Lucente, Vincent Egorov, Vladimir Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Kozma Bence (1982-) (szülész-nőgyógyász)
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