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001-es BibID:BIBFORM134831
Első szerző:Achenef, Gashew Mequanint (animal science)
Cím:Arginine shapes growth and mTOR pathway gene expression in Japanese quails (Coturnix japonica) / Mequanint Gashew, Gebrehaweria K. Reda, Fadella Nur Almira, Eman Moustafa Abdelbary, Doha Mohamad Khalifeh, Sawadi F. Ndunguru, Gabriella Gulyás, Renáta Knop, Brigitta Csernus, Csaba Szabó, Ádám Z. Lendvai, Levente Czeglédi
Dátum:2025
ISSN:2045-2322
Megjegyzések:Arginine is a crucial amino acid that regulates growth, metabolism, and cellular homeostasis through nutrient-sensing pathways such as the mechanistic target of rapamycin (mTOR). However, the mechanisms by which dietary arginine modulates mTOR signalling and associated gene networks during early development remain poorly understood in birds. Here, we tested the effects of dietary arginine levels (low, control, and high) on body mass, gene expression, and gene network connectivity in Japanese quail chicks (Coturnix japonica). Using 153 birds over a 14-day experiment, we show that post-hatch arginine restriction significantly impairs growth in both sexes, while gene expression and gene network connectivity responses to arginine availability are strongly sex-specific. Arginine supplementation in females led to coordinated upregulation of growth-related genes (IGF1, GHR), translation regulators (EIF4EBP1), lipid metabolism genes (FASN, FABP1), and oxidative defence (SOD2). In contrast, males showed more limited changes, primarily involving MTOR and autophagy-related gene ATG5. Gene network analysis revealed enhanced connectivity and centrality in females under arginine supplementation, suggesting a more extensive gene interaction response, while males showed sparser networks under restriction, with MTOR and IGF1 emerging as key regulatory hubs. These findings provide novel insights into the sensitivity of developing birds to early nutritional conditions and suggest that the mechanisms underlying growth, gene expression, and gene networking can differ between the sexes, even without sex differences in phenotypic traits. Our results highlight the importance of considering sex-specific gene regulatory architectures when evaluating nutritional effects on vertebrate development.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Amino acid
gene expression
growth
poultry
mechanistic target of rapamycin
Megjelenés:Scientific Reports. - [Epub ahead of print] (2025), p. 1-25. -
További szerzők:Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Almira, Fadella Nur (1994-) (animal scientist) AbdElbary, Eman (1991-) (animal science) Khalifeh, Doha Mohamad (1998-) (animal science) Ndunguru, Sawadi Fransisco (1980-) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
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2.

001-es BibID:BIBFORM134829
Első szerző:Achenef, Gashew Mequanint (animal science)
Cím:Dietary arginine modulates egg production and mTOR signalling pathway gene expression in adult Japanese quail (Coturnix japonica) / Mequanint Gashew, Gebrehaweria K. Reda, Fadella Nur Almira, Eman Moustafa Abdelbary, Gabriella Gulyás, Renáta Knop, Brigitta Csernus, Csaba Szabó, Ádám Z. Lendvai, Levente Czeglédi
Dátum:2026
ISSN:2451-943X
Megjegyzések:Arginine, an essential amino acid in birds, plays a central role in growth and reproduction. Regulation of the mechanistic target of rapamycin (mTOR) signalling pathway is among its key functions. This study examined how dietary arginine affects reproductive performance, body mass, and hepatic gene expression in adult female Japanese quail (Coturnix japonica). A total of 81 quails were randomly assigned to one of the three dietary treatments for 14 days: a diet containing 1.26% arginine (control), 0.945% arginine (restricted), and 1.575% arginine (supplemented). Body mass, hen-day egg production (HDEP), and egg mass were recorded, and liver samples were analysed using qPCR for mTOR signalling pathway-related genes. Arginine supplementation significantly increased HDEP, whereas neither restriction nor supplementation altered body mass or egg mass. Arginine restriction downregulated the expression of MTOR, IGF1, GHR, FASN, ATG5, ATG9A, SOD1, and SOD2 genes. In contrast, supplementation upregulated ATG5 but downregulated SOD2. Network analysis revealed treatment-dependent shifts: under restriction, SOD2 functioned as a key bridge despite reduced expression, whereas under supplementation, centrality shifted to GHR and FASN, indicating enhanced growth and lipogenic activity. Overall, dietary arginine reshaped the molecular structure of the mTOR pathway without affecting somatic maintenance, instead favouring reproductive output. These findings suggest that dietary arginine regulates egg production and gene expression in the mTOR signalling pathway in adult Japanese quail.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Japanese quail
Arginine
mTOR
Gene expression
Megjelenés:Veterinary and Animal Science. - 31 (2026), p. 1-10. -
További szerzők:Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Almira, Fadella Nur (1994-) (animal scientist) AbdElbary, Eman (1991-) (animal science) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
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3.

001-es BibID:BIBFORM134241
Első szerző:Achenef, Gashew Mequanint (animal science)
Cím:Differential regulation of genes by arginine in Japanese quail / Mequanint Gashew, Fadella A. Nur, Eman AbdElbary, Sawadi F. Ndunguru, Gebrehaweria K. Reda, Gabriella Gulyás, Renáta Knop, Brigitta Csernus, Csaba Szabó, Ádám Z. Lendvai, Levente Czeglédi
Dátum:2025
ISBN:978-80-552-2916-4
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
arginine
gene expression
Japanese quail
Megjelenés:Animal Science Days 2025: Book of Abstracts: 33rd International Symposium, September 23-26, 2025 Nitra, Slovakia/ ed. Radovan Kasarda, Nina Moravčíková, Ľubica Jamborová. - p. 57. -
További szerzők:Almira, Fadella N. AbdElbary, Eman (1991-) (animal science) Ndunguru, Sawadi Fransisco (1980-) Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Gulyás Gabriella (1985-) (agrár) Knop Renáta (1983-) (állatorvos) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
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4.

001-es BibID:BIBFORM126178
Első szerző:Achenef, Gashew Mequanint (animal science)
Cím:Effect of arginine on Japanese quail performance: Preliminary findings / Mequanint Gashew Achenef, Ádám Lendvai, Levente Czeglédi, Renáta Knop, Csaba Szabó, Gebrehaweria K. Reda, Sawadi F. Ndunguru, Fadella N. Almira
Dátum:2024
Megjegyzések:This study investigates the effects of three different feeding regimes (25% arginine supplementation, 25% arginine restriction, and standard National Research Council-recommended feed) and sex on the performance of grower Japanese quail for fourteen days trial. The total number of quail was 151, with 81 females and 70 males. A two-way analysis of variance was performed to evaluate the interaction between feed type and sex on live weight. The results show a significant (p < 0.001) effect of feed treatment on final live weight and body weight gain, while sex did not significantly (p > 0.05) affect final live weight or weight gain. The findings revealed that quail fed with 25% arginine-restricted diet had significantly (p < 0.001) lower live weights (126.99 ? 2.41) compared to those subjected to 25% arginine supplementation (144.05 ? 1.60) and control feed regime (140.6 ? 1.88). Furthermore, no significant (p = 0.74) interaction between feed type and sex on live weight was observed. The results also indicated a significant (p = 0.02) effect of feed type on feed intake. These findings suggest that dietary arginine levels critically influence live weight changes in grower Japanese quail, while sex does not exert a significant impact. The insignificant interaction between feed type and sex indicates that arginine levels affect live weight in a similar way for both males and females. This study provides valuable insights for optimizing dietary arginine levels to enhance live weight, body weight gains and feed intake performance in grower Japanese quail.
ISBN:978-963-623-106-4
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
arginine
Japanese quail
performance
Megjelenés:IX. Gödöllői Állattenyésztési Tudományos Nap: Előadások és poszterek összefoglaló kötete = 9th Scientific Day of Animal Breeding in Gödöllő : Book of Abstracts of Presentations and Posters /szerk. Bényi Erzsébet, Bodnár Ákos, Pajor Ferenc, Póti Péter. - p. 54. -
További szerzők:Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök) Knop Renáta (1983-) (állatorvos) Szabó Csaba (1968-) (agrármérnök) Reda, Gebrehaweria Kidane (1986-) (Animal Sceince) Ndunguru, Sawadi Fransisco (1980-) Almira, Fadella N.
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5.

001-es BibID:BIBFORM122179
Első szerző:Achenef, Gashew Mequanint (animal science)
Cím:The effect of mtor and related signaling pathway on ageing in birds / Mequanint Gashew, Achenef, Adam Lendvai, Levente Czegledi
Dátum:2024
Megjegyzések:An organism's lifespan is governed by the mechanistic target of rapamycin (mTOR) and insulin-like insulin growth factor signaling (IIS) pathways. This review seeks to explore the influence of mTOR and its related signaling pathways on the ageing process in avian species. In birds, this pathway plays a crucial role in regulating physiological effects, longevity, and the ageing phenomenon. Both rapamycin and dietary restrictions have demonstrated the ability to inhibit mTOR, leading to an extension of the maximum lifespan in model organisms. Ageing is charac-terized by a gradual decline in physiological function, impacting overall performance, increa-sing susceptibility to death, and diminishing life expectancy. Addressing this issue through mTOR inhibition via dietary restriction and rapamycin administration, as observed in model organisms, presents a potential solution. Despite similarities, a physiological paradox exists between mammals and birds. Additionally, it is reasonable to infer significant differences in the physiological systems of birds compared to mammals. Variations in how sexes allocate resour-ces to different aspects of reproduction can contribute to differences in longevity and ageing, driven by trade-offs in life history. Despite the limited research conducted on birds ageing, the potential impact of mTOR modulation through interventions remains an intriguing area for furt-her exploration.
ISBN:978-963-306-980-6
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
ageing
mTOR
birds
Megjelenés:21st Wellmann International Scientific Conference Book of abstracts / felelős kiadó Edit Mikó, szerk. Ingrid Melinda Gyalai, Szilárd Czóbel. - p. 34. -
További szerzők:Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
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