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001-es BibID:	BIBFORM113710
035-os BibID:	(WoS)001046283500001 (Scopus)85167680789
Első szerző:	Kovács Dóra (Biológus)
Cím:	Linoleic Acid Induced Changes in SZ95 Sebocytes-Comparison with Palmitic Acid and Arachidonic Acid / Dóra Kovács, Emanuela Camera, Szilárd Póliska, Alessia Cavallo, Miriam Maiellaro, Katalin Dull, Florian Gruber, Christos C. Zouboulis, Andrea Szegedi, Dániel Törőcsik
Dátum:	2023
ISSN:	2072-6643
Megjegyzések:	Linoleic acid (LA) is an essential omega-6 polyunsaturated fatty acid (PUFA) derived from the diet. Sebocytes, whose primary role is to moisturise the skin, process free fatty acids (FFAs) to produce the lipid-rich sebum. Importantly, like other sebum components such as palmitic acid (PA), LA and its derivative arachidonic acid (AA) are known to modulate sebocyte functions. Given the different roles of PA, LA and AA in skin biology, the aim of this study was to assess the specificity of sebocytes for LA and to dissect the different roles of LA and AA in regulating sebocyte functions. Using RNA sequencing, we confirmed that gene expression changes in LA-treated sebocytes were largely distinct from those induced by PA. LA, but not AA, regulated the expression of genes related to cholesterol biosynthesis, androgen and nuclear receptor signalling, keratinisation, lipid homeostasis and differentiation. In contrast, a set of mostly down-regulated genes involved in lipid metabolism and immune functions overlapped in LA- and AA-treated sebocytes. Lipidomic analyses revealed that the changes in the lipid profile of LA-treated sebocytes were more pronounced than those of AA-treated sebocytes, suggesting that LA may serve not only as a precursor of AA but also as a potent regulator of sebaceous lipogenesis, which may not only influence the gene expression profile but also have further specific biological relevance. In conclusion, we have shown that sebocytes are able to respond selectively to different lipid stimuli and that LA-induced effects can be both AA-dependent and independent. Our findings allow for the consideration of LA application in the therapy of sebaceous gland-associated inflammatory skin diseases such as acne, where lipid modulation and selective targeting of AA metabolism are potential treatment options.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Nutrients. - 15 : 15 (2023), p. 1-20. -
További szerzők:	Camera, Emanuela Póliska Szilárd (1978-) (biológus) Cavallo, Alessia Maiellaro, Miriam Dull Katalin (1983-) (molekuláris biológus, genetikus) Gruber, Florian Zouboulis, Christos C. (1960-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász) Töröcsik Dániel (1979-) (bőrgyógyász)
Pályázati támogatás:	FK-132296 OTKA ANN 139589 OTKA K-128250 OTKA Italian Ministry of Health Egyéb FWF Austrian Science Fund; I 5627-B Egyéb
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM120441
035-os BibID:	(WoS)001174117000001 (Scopus)85186470038
Első szerző:	Seiringer, Peter
Cím:	Spatial transcriptomics reveals altered lipid metabolism and inflammation-related gene expression of sebaceous glands in psoriasis and atopic dermatitis / Peter Seiringer, Christina Hillig, Alexander Schäbitz, Manja Jargosch, Anna Caroline Pilz, Stefanie Eyerich, Andrea Szegedi, Michaela Sochorová, Florian Gruber, Christos C. Zouboulis, Tilo Biedermann, Michael P. Menden, Kilian Eyerich, Daniel Törőcsik
Dátum:	2024
ISSN:	1664-3224
Megjegyzések:	Sebaceous glands drive acne, however, their role in other inflammatory skin diseases remains unclear. To shed light on their potential contribution to disease development, we investigated the spatial transcriptome of sebaceous glands in psoriasis and atopic dermatitis patients across lesional and non-lesional human skin samples. Both atopic dermatitis and psoriasis sebaceous glands expressed genes encoding key proteins for lipid metabolism and transport such as ALOX15B, APOC1, FABP7, FADS1/2, FASN, PPARG, and RARRES1. Also, inflammation-related SAA1 was identified as a common spatially variable gene. In atopic dermatitis, genes mainly related to lipid metabolism (e.g. ACAD8, FADS6, or EBP) as well as disease-specific genes, i.e., Th2 inflammation-related lipid-regulating HSD3B1 were differentially expressed. On the contrary, in psoriasis, more inflammation-related spatially variable genes (e.g. SERPINF1, FKBP5, IFIT1/3, DDX58) were identified. Other psoriasis-specific enriched pathways included lipid metabolism (e.g. ACOT4, S1PR3), keratinization (e.g. LCE5A, KRT5/7/16), neutrophil degranulation, and antimicrobial peptides (e.g. LTF, DEFB4A, S100A7-9). In conclusion, our results show that sebaceous glands contribute to skin homeostasis with a cell type-specific lipid metabolism, which is influenced by the inflammatory microenvironment. These findings further support that sebaceous glands are not bystanders in inflammatory skin diseases, but can actively and differentially modulate inflammation in a disease-specific manner.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Frontiers in Immunology. - 15 (2024), p. 1-10. -
További szerzők:	Hillig, Christina Schäbitz, Alexander Jargosch, Manja Pilz, Anna Caroline Eyerich, Stefanie Szegedi Andrea (1964-) (bőrgyógyász) Sochorová, Michaela Gruber, Florian Zouboulis, Christos C. (1960-) (bőrgyógyász) Biedermann, Tilo Menden, Michael P. Eyerich, Kilian Töröcsik Dániel (1979-) (bőrgyógyász)
Pályázati támogatás:	ANN 139589 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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