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001-es BibID:	BIBFORM007054
Első szerző:	Bodolay Edit (belgyógyász, allergológus és klinikai immunológus)
Cím:	Evaluation of interstitial lung disease in mixed connective tissue disease (MCTD) / Bodolay, E., Szekanecz, Z., Devenyi, K., Galuska, L., Csipo, I., Vegh, J., Garai, I., Szegedi, G.
Dátum:	2005
ISSN:	1462-0324
Megjegyzések:	Interstitial lung disease (ILD) may be a characteristic, often serious, manifestation of mixed connective tissue disease (MCTD). In this retrospective study, the frequency and clinical picture of ILD were determined in patients with MCTD using two diagnostic tests: high-resolution computed tomography (HRCT) and inhaled aerosol clearance times of (99m)Tc-labelled diethylene-triamine pentaacetate ((99m)Tc-DTPA). In addition, pulmonary function, effects of therapy and a variety of immunoserological markers were also assessed. METHODS: One hundred and forty-four consecutive patients with MCTD were selected from the clinic, irrespective of the presence or absence of ILD. All patients underwent a detailed clinical assessment, chest HRCT scanning, chest radiography, inhaled aerosol of (99m)Tc-DTPA clearance times, and all pulmonary function tests. Patients who had active ILD received corticosteroid (CS) or CS in combination with cyclophosphamide (CPH). All investigations were repeated after 6 months of immunosuppressive therapy. RESULTS: Ninety-six out of 144 MCTD patients (66.6%) had active ILD, 75 of this group (78.1%) showed ground glass opacity, 21 patients (21.8%) ground glass opacity with mild fibrosis with HRCT. Forty-five patients with active ILD received 2 mg/kg/day CS for 6-8 weeks alone and 51 patients CS in combination with CPH (2 mg/kg/day). Six months later, after therapy, 67 out of 96 MCTD patients with ILD (69.8%) showed a negative HRCT pattern, ground glass opacity with mild fibrosis developed in 15 patients (15.6%), and fibrosis was detected in 13 patients (13.5%). Only one patient showed subpleural honeycombing. (99m)Tc-DTPA was rapid in all 96 MCTD patients with active ILD (28.7 +/- 8.2 min, normal value >40 min). After therapy the (99m)Tc-DTPA was normalized, 79 out of 96 patients (82.3%). Carbon monoxide diffusion capacity (DLCO) was reduced in 33 out of 96 MCTD patients with active ILD (34.3%), while there were no significant differences in the pulmonary function tests between the active versus inactive stage of ILD or versus patients without ILD. The sera of 96 MCTD patients with active ILD contained a high level of immune complexes (ICs), and the total haemolytic complement levels (CH50/ml U) decreased. After 6 months of therapy, the IC levels decreased and CH50/ml levels normalized (MCTD patients before and after active ILD: IC optical density = 355 +/- 227 vs 206 +/- 92, P<0.001; CH50/ml, 38.0 +/- 12.6 U vs 64.3 +/- 13.0 U, P<0.001). CONCLUSIONS: HRCT is the gold standard for diagnosis of ILD. However, we used another method, (99m)Tc-DTPA, in order to compare this technique with HRCT. This latter technique has not been studied previously in MCTD. The elevated levels of IC and increased complement consumption indicated that IC-mediated alveolocapillary membrane damage and tissue injury might play a role in the pathogenesis of ILD in MCTD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Aged Cyclophosphamide Drug Therapy, Combination Female Glucocorticoids Humans Lung Diseases, Interstitial imaging Male Methylprednisolone Middle Aged Mixed Connective Tissue Disease Radiopharmaceuticals Respiratory Function Tests Retrospective Studies Technetium Tc 99m Pentetate Tomography, X-Ray Computed egyetemen (Magyarországon) készült közlemény
Megjelenés:	Rheumatology (Oxford). - 44 : 5 (2005), p. 656-661. -
További szerzők:	Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Dévényi Katalin Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Csípő István (1953-) (vegyész) Végh Judit (1968-) (belgyógyász, kardiológus) Garai Ildikó (1966-) (radiológus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	elektronikus változat elektronikus változat DOI
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001-es BibID:

BIBFORM124779

Első szerző:

Simon Zsófia (belgyógyász, haematológus)

Cím:

Myocardial lesions in long-term survivers of Hodgkin disease; an echocardiographic and dual isotope F-18 FDG/Tc-99m MIBI SPECT study / Zsófia Simon, Ildikó Garai, Judit Végh, Zsófia Miltényi, József Varga, Lajos Szabados, László Galuska, Árpád Illés

Dátum:

2008

Megjelenés:

Utánközlés / Nyelvi változat

ISSN:

0133-5596

Megjegyzések:

Introduction: By using modern treatment modalities, the survival of Hodgkin lymphoma patients is getting better; they are cured and that is why late complications have come to the focus. Among them, cardiovascular complications have the highest risk besides second malignancies. Aims: To survey the incidence and seriousness of myocardial damage of our Hodgkin lymphoma patients. Patients and methods: Data of 76 Hodgkin lymphoma patients, who had been in complete remission for at least five years and may or may not experienced chest pain, were analyzed. We assessed their conventional cardiovascular risk factors and the applied anticancer treatment; we also performed resting and stress ECG, echocardiography, and F-18 FDG/Tc-99m MIBI DISA SPECT tests. Results: Based on the results of the DISA test, the patients were divided into two groups: 42 patients had perfusion and/or metabolic myocardial lesions, among them there were more males, but as for the age, risk factors, and the applied treatment, they did not differ significantly from those whose DISA test was negative. Positive DISA tests showed significant correlation with chest pain. Mostly the anterior and inferior segments were affected. The type of the lesion did not correlate with the treatment modality. Conclusions: Both perfusion and metabolic derangement of the myocardium can cause chest pain and affect the quality of life. DISA test is a sensitive method used in detecting myocardial dysfunction. It can help us with the differentiation of metabolic disorders and small or large vessel diseases causing chest pain, the latter of which may need intervention.
Simon Zsófia (1977-) (belgyógyász, haematológus): Késői miokardiális károsodás vizsgálata Hodgkin lymphomás betegekben echocardiográfiával és dual izotóp F-18 FDG és Tc-99m MIBI SPECT-tel

Tárgyszavak:

Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
DISA
Hodgkin lymphoma
late cardiac complications
quality of life
survival

Megjelenés:

Cardiologia Hungarica. - 38 (2008), p. 336-343. -

További szerzők:

Garai Ildikó (1966-) (radiológus) Végh Judit (1968-) (belgyógyász, kardiológus) Miltényi Zsófia (1975-) (belgyógyász, haematológus) Varga József (1955-) (fizikus) Szabados Lajos (1977-) (orvos) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)

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Intézményi repozitóriumban (DEA) tárolt változat

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Utánközlés (1)

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001-es BibID:

BIBFORM006941

Első szerző:

Simon Zsófia (belgyógyász, haematológus)

Cím:

Késői miokardiális károsodás vizsgálata Hodgkin lymphomás betegekben echocardiográfiával és dual izotóp F-18 FDG és Tc-99m MIBI SPECT-tel / Simon Zsófia, Garai Ildikó, Végh Judit, Miltényi Zsófia, Varga József, Szabados Lajos, Galuska László, Illés Árpád

Dátum:

2008

Megjegyzések:

Simon Zsófia (1977-) (belgyógyász, haematológus): Myocardial lesions in long-term survivers of Hodgkin disease; an echocardiographic and dual isotope F-18 FDG/Tc-99m MIBI SPECT study

Tárgyszavak:

Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
egyetemen (Magyarországon) készült közlemény

Megjelenés:

Cardiologia Hungarica. - 38 (2008), p. 328-335. -

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Internet cím:

elektronikus változat

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