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001-es BibID:	BIBFORM065716
Első szerző:	Dajnoki Zsolt (molekuláris biológus)
Cím:	Immune-mediated Skin Inflammation is Similar in Severe Atopic Dermatitis Patients With or Without Filaggrin Mutation / Zsolt Dajnoki, Gabriella Béke, Gábor Mócsai, Anikó Kapitány, Krisztián Gáspár, Krisztina Hajdu, Gabriella Emri, Bence Nagy, Ilona Kovács, Lívia Beke, Balázs Dezső, Andrea Szegedi
Dátum:	2016
ISSN:	0001-5555
Megjegyzések:	Inflammatory cytokines can impair the skin barrier,but the question as to whether barrier alterations affectkeratinocyte immune responses remains unanswered.The aim of this study was to investigate whetherimmune-mediated skin inflammation differs between severeatopic dermatitis patients with or without filaggrinmutation. The levels of filaggrin, inflammatory T helper2 polarizing cytokines (thymic stromal lymphopoietin(TSLP) and interleukin 33 (IL-33)) and chemokine (C-Cmotif) ligand 27 (CCL27), histological severity markers,T-cell and dendritic cell counts in biopsies from lesionalskin of severe atopic dermatitis patients with and withoutfilaggrin mutation and healthy skin were quantifiedby immunohistochemistry. The results were confirmedby quantitative PCR analyses. No significant differenceswere found between the 2 patient groups. Expression ofatopic dermatitis-specific cytokines showed significantcorrelation with histological severity. These findingssuggest that the immune-mediated skin inflammation(represented by keratinocyte-derived factors, T-cell anddendritic cell counts) is similar in the 2 patient groupswith severe atopic dermatitis, and that immune activationis connected to the severity of the disease ratherthan to the origin of barrier alterations. Key words:atopic dermatitis; filaggrin; immunohistochemistry; innateimmunity; thymic stromal lymphopoietin.Accepted Oct 29, 2015; Epub ahead of print Nov 5, 2015
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Acta Dermato-Venereologica 96 : 5 (2016), p. 645-650. -
További szerzők:	Béke Gabriella (1987-) (molekuláris biológus) Mócsai Gábor (1984-) (PhD hallgató) Kapitány Anikó (1979-) (molekuláris biológus) Gáspár Krisztián (1974-) (bőrgyógyász) Steuer-Hajdu Krisztina (1990-) (bőrgyógyász) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Nagy Bence (1982-) (pathológus) Kovács Ilona (1965-) (patológus) Beke Lívia (1971-) (orvosdiagnosztikai laboratóriumi analitikus) Dezső Balázs (1951-) (pathológus) Szegedi Andrea (1964-) (bőrgyógyász)
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001-es BibID:	BIBFORM122571
035-os BibID:	(Scopus)85128249106 (WOS)000815784200046
Első szerző:	De Smedt, Julie
Cím:	Determinants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population / Julie De Smedt, Sofie Van Kelst, Laudine Janssen, Vivien Marasigan, Veerle Boecxstaens, Marguerite Stas, Dirk Vanderschueren, Ipek Guler, Kris Bogaerts, Katleen Vandenberghe, Oliver Bechter, Jaak Billen, Arjen Nikkels, Tine Strobbe, Gabriella Emri, Diether Lambrechts, Marjan Garmyn
Dátum:	2022
ISSN:	0001-5555
Megjegyzések:	Vitamin D status is influenced by well-known deter-minants, but factors associated with low 25-hydroxy-vitamin D levels in the cutaneous melanoma popula-tion are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous mela-noma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood with-drawal, Fitzpatrick phototype, vitamin D supplemen-tation, score for intensity of lifetime sun exposure, smok ing, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and pa-rameters of chronic sun damage was investigated. In addition, 25-hydroxyvitamin D levels were correlated with pathological parameters of the primary tumour and melanoma stage (8th edition of the American Joint Committee on Cancer (AJCC). Univariate and multi-variate logistic regressions were performed using R software. The following factors had a significant effect on vitamin D status: body mass index, seasonal time of blood sampling, vitamin D supplementation, and a subtype of skin, and hair colour.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk melanoma vitamin D body mass index
Megjelenés:	Acta Dermato-Venereologica. - 102 (2022), p. 1-7. -
További szerzők:	Van Kelst, Sofie Janssen, Laudine Marasigan, Vivien Boecxstaens, Veerle Stas, Marguerite Vanderschueren, Dirk Guler, Ipek Bogaerts, Kris Vandenberghe, Katleen Bechter, Oliver Billen, Jaak Nikkels, Arjen Strobbe, Tinne Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Lambrechts, Dieter (1976-) (genetikus) Garmyn, Marjan
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