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1.

001-es BibID:BIBFORM037838
Első szerző:Lonovics János (Szeged)
Cím:Regional differences in nitric oxide-mediated relaxation of the rabbit sphincter of Oddi / János Lonovics, Ildikó Jakab, Judith Szilvássy, Zoltán Szilvássy
Dátum:1994
ISSN:0014-2999
Megjegyzések:We studied the role of the L-arginine-nitric oxide (NO) pathway in non-adrenergic, non-cholinergic (NANC) relaxation of the rabbit sphincter of Oddi by recording changes in isometric tension in response to electrical field stimulation in two series of experiments. In a first set of experiments, biliary sphincters of Oddi removed from New Zealand white rabbits were placed horizontally in an organ bath containing oxygenized, buffered (pH 7.4) Krebs solution. Contractile responses of the whole sphincter to field stimulation were determined. In the second set of experiments, sphincter of Oddi was divided into two parts and the effects of field stimulation were studied separately on areas close to the duodenal papilla (area I) and areas close to the common bile duct (area II). In the whole sphincter of Oddi, field stimulation induced an initial twitch-like contraction followed by relaxation proportional to the number of stimuli (3 and 10 stimuli at 20 Hz, 50 V, 0.1 ms). The magnitude of the contractile responses was considerably reduced by 1 microM atropine, phentolamine and oxprenolol (NANC solution). Field stimulation produced dose-dependent contractions of both segments of sphincter of Oddi in response to the same protocol as used with whole sphincter of Oddi. However, preincubation with NANC solution produced monophasic relaxations in response to field stimulation in area I, whereas area II preparations such as the whole sphincter of Oddi responded with contractions followed by minimal relaxations. Field stimulation failed to induce either contractions or relaxations in the presence of 1 microM tetrodotoxin.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
tetrodotoxin
nitric oxide
field stimulation
neural relaxation
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Pharmacology. - 255 : 1-3. (1994), p. 117-122. -
További szerzők:Jakab Ildikó (farmakológus) Szilvássy Judit (1960-2022) (fül- orr- gégész) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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2.

001-es BibID:BIBFORM020575
Első szerző:Sári Réka (farmakológus)
Cím:Cross tolerance between nitroglycerin and neural relaxation of the rabbit sphincter of Oddi / Réka Sári, Zoltán Szilvássy, Ildikó Jakab, István Nagy, János Lonovics
Dátum:1998
ISSN:1043-6618
Megjegyzések:Szegedi Tudományegyetem - Belgyógyászati Klinika
We studied whether non-adrenergic, non-cholinergic (NANC) relaxation of the rabbit sphincter of Oddi was influenced by tolerance to nitroglycerin (NG)in vitro. Sphincter of Oddi (SO) muscle rings precontracted with EC50concentrations of cholecystokinin octapeptide (CCK8) were exposed to cumulative increases in NG concentrations and tested for relaxation by measurement of isometric tension. A separate group of six rings was subjected to a preceding exposure to 275 mnitroglycerin over 60 min to inducein vitrotolerance to nitroglycerin. The rings (both tolerant and non-tolerant) were subjected to electrical field stimulation (FS: 50 V, 0.1 ms, 20 Hz, 3 and 10 stimuli). The rings were then preincubated with NANC solution: phentolamine, oxprenolol and atropine (all 1 m) for 20 min and FS was applied again. FS was repeated after additional incubation withNG-nitro-l-arginine methyl ester (l-NAME), an inhibitor of NO synthase (30 m) and after a successive incubation with 3 mml-arginine (20 min). Maximum contractions produced by CCK8 in `tolerant' and 'non-tolerant' sphincters were 29.9±5.8 and 28.3±5.2 mN, respectively. The sensitivity to CCK8 also was not different between the two groups with EC50(-log M) values of 8.5±0.2 and 8.3±0.1, respectively. FS evoked twitchlike contraction followed by relaxation in the ampullary SO in both `tolerant' and `non-tolerant' preparations. Incubation in NANC solution resulted in monophasic relaxations in response to FS in non-tolerant sphincters but not in tolerant ones.l-NAME (30 m) reversed NANC relaxation in non-tolerant muscle rings whereas it failed to modify NANC contractions in the tolerant preparations.l-arginine (3 mm) reversed the inhibitory effect ofl-NAME on NANC relaxation in the `non-tolerant' rings and it was without effect on FS-induced contractions in the `tolerant' SO. As measured by radioimmunoassay, tolerance to NG was without any significant effect on tissue content of both cyclic adenosine 3:5 monophosphate (cAMP) and cyclic guanosine 3:5 monophosphate (cGMP). FS significantly increased tissue cAMP and cGMP content in 'non-tolerant' preparations. FS failed to increase the level of either cyclic nucleotide in `tolerant' tissue. We conclude that NANC relaxation of the ampullary part of the rabbit SO is significantly impaired in the state of tolerance to NG`in vitro'.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
cross tolerance
nitroglycerin
neural relaxation
Megjelenés:Pharmacological Research. - 37 : 6 (1998), p. 505-512. -
További szerzők:Jakab Ildikó (farmakológus) Nagy István Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Internet cím:DOI
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3.

001-es BibID:BIBFORM046507
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Glibenclamide sensitivity of neural relaxation of the rabbit sphincter of oddi / Zoltan Szilvassy, Janos Lonovics, Ildiko Jakab, Istvan Nagy
Dátum:1997
ISSN:1043-6618
Megjegyzések:In this article we studied whether the nitrergic relaxation of the rabbit sphincter wassensitive to glibenclamide. Field stimulation relaxed the sphincter of Oddi rings afterincubation with atropine 1 mM. and guanethidine 4 mM. with threefold and fourfoldincreases in tissue guanosine 39:59-cyclic monophosphate and adenosine 39:59-cyclicmonophosphate contents, respectively. These changes were blocked by 30 mM NG-nitro-L-arginine methyl ester. Glibenclamide 0.1]10 mM. attenuated the field stimulation-inducedrelaxation and completely abolished the relaxation produced by 0.1 mM cromakalim. Weconclude that nitrergic relaxation of the rabbit sphincter of Oddi comprises a mechanismsensitive to glibenclamide.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
nitric oxide NO
glibenclamide
field stimulation
cyclic nucleotides
sphincter of Oddi
Megjelenés:Pharmacological Research. - 36 : 2 (1997), p. 129-133. -
További szerzők:Lonovics János (Szeged) Jakab Ildikó (farmakológus) Nagy István
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4.

001-es BibID:BIBFORM046510
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:The effect of continuous versus intermittent treatment with transdermal nitroglycerin on pacing-induced preconditioning in conscious rabbits / Z. Szilvassy, P. Ferdinandy, I. Nagy, I. Jakab, M. Koltai
Dátum:1997
ISSN:0007-1188
Megjegyzések:1 Tolerance to the hypotensive e?ect of nitroglycerin (NG) blocks preconditioning induced by rapidventricular pacing (RVP) in rabbits. In the present work the e?ect of continuous versus intermittenttreatment with transdermal nitroglycerin on the pacing-induced preconditioning phenomenon wasstudied in conscious rabbits.2 RVP (500 beats min71 over 5 min) increased left ventricular end-diastolic pressure (LVEDP) frombaseline 4.1+0.9 to postpacing 13.8+2.9 mmHg (P50.001) with a right intraventricular ST-segmentelevation of 1.25+0.13 mV, two indicators of myocardial ischaemia. These changes were signi?cantlyattenuated when the RVP period was preceded by a preconditioning pacing of the same rate andduration with an interpacing interval of 5 min.3 Protection by preconditioning was abolished when the animals had been made tolerant to thevasodilator e?ect of 30 mg kg71 NG by the application of transdermal NG (approx. 0.07 mg kg71 h71)over 7 days. Furthermore, transdermal NG per se attenuated both RVP-induced ST-segment elevationand LVEDP-increase over the 7 day period.4 With intermittent transdermal NG treatment (12 h 'patch on' vs 'patch o?'), neither development ofvascular tolerance nor attenuation of the NG- or preconditioning-induced anti-ischaemic e?ects wereobserved. However, the severity of pacing-induced myocardial ischaemia was signi?cantly increasedduring the 'patch o?' periods.5 In a second set of experiments, postpacing changes in cardiac cyclic GMP and cyclic AMP levelswere determined by means of radioimmunoassay in chronically instrumented anaesthetized open-chestrabbits with the same NG-treatment protocols. Preconditioning reduced postpacing increase in cyclicAMP with an increase in cyclic GMP concentrations in hearts of the untreated animals and in thosegiven patches intermittently during both 'patch on' and 'patch o?' periods. However, the preconditioninge?ect on either cyclic nucleotide was blocked in the tolerant animals.6 Transdermal NG increased resting levels of both cardiac cyclic nucleotides in the non-tolerant butnot in the tolerant state. The postpacing increase in cyclic AMP content was inhibited by transdermalNG, independent of vascular tolerance development, whereas, an increase in cyclic GMP content wasexclusively seen in the non-tolerant animals.7 We conclude that the anti-ischaemic effect of NG is independent of the cyclic GMP mechanism in thetolerant state. While intermittent NG therapy prevents development of vascular tolerance and preservespreconditioning, the nitrate-free periods yield an increased susceptibility of the heart to ischaemicchallenges.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ischaemic preconditioning
nitrate tolerance
rapid pacing
cyclic GMP
intermittent nitrate therapy
Megjelenés:British Journal of Pharmacology. - 121 : 3 (1997), p. 491-496. -
További szerzők:Ferdinándy Péter Nagy I. Jakab Ildikó (farmakológus) Koltai Mátyás
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5.

001-es BibID:BIBFORM037827
035-os BibID:PMID:8773472
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Impaired nitrergic relaxation of the sphincter of Oddi of hyperlipidaemic rabbits / Zoltan Szilvassy, Istvan Nagy, Judith Szilvassy, Ildiko Jakab, Sandor Csati, Janos Lonovics
Dátum:1996
ISSN:0014-2999
Megjegyzések:Field stimulation relaxed the sphincter of Oddi muscle rings of the rabbit after incubation with phentolamine, oxprenolol and atropine (all 1 microM). The relaxation was blocked by NG-nitro-L-arginine methyl ester (30 microM) and was reversed by 3 mM L-arginine but not D-arginine. Sphincter of Oddi preparations from hypercholesterolaemic rabbits exhibited contractions under the same conditions. We conclude that nitrergic relaxation is impaired in the sphincter of Oddi from hypercholesterolaemic rabbits.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Nitric oxide
NO
hypercholesterolemia
egyetemen (Magyarországon) készült közlemény
Megjelenés:European Journal of Pharmacology. - 301 : 1-3 (1996), p. R17-R18. -
További szerzők:Nagy István Szilvássy Judit (1960-2022) (fül- orr- gégész) Jakab Ildikó (farmakológus) Csáti Sándor Lonovics János (Szeged)
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6.

001-es BibID:BIBFORM037828
035-os BibID:PMID:7952889
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin / Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Szilvassy, I. Nagy, J. Lonovics, M. Koltai
Dátum:1994
ISSN:0007-1188
Megjegyzések:A preceding right ventricular overdrive pacing (VOP) of 500 b.p.m. for 5 min, markedly reduced the severity of global myocardial ischaemia produced by a subsequent 5-min VOP in conscious rabbits. This VOP-induced preconditioning developed in parallel with an increase in cardiac cyclic guanosine 3':5'-monophosphate (cyclic GMP) content. VOP-induced preconditioning was abolished when the animals had been made tolerant to the vasodilator effect of nitroglycerin (NG). In the heart of the NG-tolerant rabbits, neither VOP nor preconditioning increased cyclic GMP content. This suggests that changes by NG tolerance of cyclic GMP metabolism may account for the loss of VOP-induced preconditioning.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ischaemic preconditioning
nitroglycerin tolerance
cyclic GMP
ST-segment elevation
LVEDP
rabbit heart
egyetemen (Magyarországon) készült közlemény
Megjelenés:British Journal of Pharmacology. - 112 : 4 (1994), p. 999-1001. -
További szerzők:Ferdinándy Péter Bor P. Jakab Ildikó (farmakológus) Szilvássy Judit (1960-2022) (fül- orr- gégész) Nagy István Lonovics János (Szeged) Koltai Mátyás
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