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001-es BibID:	BIBFORM120447
035-os BibID:	(Scopus)85190128657 (WoS)001201644800001
Első szerző:	Szántó Dorottya (aneszteziológus, intenzív terápiás szakorvos)
Cím:	Correlation of Inflammatory Parameters with the Development of Cerebral Vasospasm, Takotsubo Cardiomyopathy, and Functional Outcome after Spontaneous Subarachnoid Hemorrhage / Dorottya Szántó, Péter Luterán, Nikolett Kóti, Péter Siró, Éva Simon, Zsuzsa Jakab, Judit Gál, János Kappelmayer, Béla Fülesdi, Csilla Molnár
Dátum:	2024
ISSN:	2077-0383
Megjegyzések:	Background: The present work aimed to determine whether a relationship exists between inflammatory parameters and the development of vasospasm (VS) and Takotsubo cardiomyopathy (TTC), as well as clinical outcome, in patients suffering from spontaneous subarachnoid hemorrhage (SAH). Methods: In this study, the authors processed the prospectively collected laboratory and clinical data of spontaneous SAH patients admitted to the neurointensive care unit between March 2015 and October 2023. The highest values of neutrophils (NEUpeak), monocytes (MONOpeak), neutrophil-to-lymphocyte ratio (NLRpeak), and CRP (CRPpeak) during the initial 7 days were correlated with the occurrence of VS and TTC, and with the outcome measures at day 30 after onset. Results: Data were collected from 175 SAH patients. Based on ROC analysis, for the development of VS, MONOpeak was the most accurate indicator (AUC: 0.619, optimal cut-off: 1.45 G/L). TTC with severe left ventricular dysfunction (ejection fraction < 40%) was indicated most sensitively by NEUpeak (ROC: 0.763, optimal cut-off: 12.34 G/L). Both for GOS and Barthel Index at day 30, CRPpeak was the best predictor for the outcome (GOS: ROC: 0.846, optimal cut-off: 78.33 mg/L and Barthel Index: ROC: 0.819, optimal cut-off: 78.33 mg/L). Conclusions: Laboratory parameters referring to inflammation during the initial 7 days after SAH correlate with the development of VS and TTC, and thus may predict functional outcome.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk subarachnoid hemorrhage vasospasm delayed cerebral ischemia Takotsubo cardiomyopathy systemic inflammatory response
Megjelenés:	Journal of Clinical Medicine. - 13 : 7 (2024), p. 1-12. -
További szerzők:	Luterán Péter (1991-) (aneszteziológus) Kóti Nikolett (1998-) (orvostanhallgató) Siró Péter (1973-) (neurológus, aneszteziológus, intenzív terápiás szakorvos) Simon Éva (1963-) (aneszteziológus) Jakab Zsuzsa (1982-) (aneszteziológus) Gál Judit (1977-) (aneszteziológiai és ITO szakorvos) Kappelmayer János (1960-) (laboratóriumi szakorvos) Fülesdi Béla (1961-) (aneszteziológus) Molnár Csilla (1962-) (aneszteziológus)
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001-es BibID:	BIBFORM115392
Első szerző:	Szántó Dorottya (aneszteziológus, intenzív terápiás szakorvos)
Cím:	Correlation of Various Laboratory Parameters with Vasospasm and Outcome in Acute Non-traumatic Subarachnoid Hemorrhage / Szántó Dorottya, Kóti Nikolett, Gál Judit, Fülesdi Béla, Molnár Csilla
Dátum:	2023
ISSN:	1351-5101
Megjegyzések:	Background and aims: Among patients with acute subarachnoid hemorrhage (SAH) lower hemoglobin (Hgb) levels and elevated white blood cell (WBC) count and C-reactive protein (CRP) levels are common. We aimed to investigate these parameters as possible early indicators of vasospasm (VS) and outcome. Methods: Subgroup analysis of our previous prospective study was performed. In total, 116 acute, non-traumatic SAH patients with daily transcranial color Doppler (TCCD) reports were enrolled in our analysis. VS was defined as >120 cm/s mean blood flow velocity in the medial cerebral artery. The following data were also processed: SAH severity scores (Modified Fisher, Hunt-Hess, WFNS), laboratory parameters on the first week after SAH (WBC, CRP, Hgb), and 1 and 6-month outcome scores (Glasgow Outcome Scale, Barthel Scale). Results: VS was detected in 31% of the cases. Patients with VS have significantly lower Hgb level (p=0.008) and higher WBC count (p=0.002) compared to patients without VS. There was no significant difference in CRP levels (p=0.201). Extended SAH and severe neurological damage were connected to higher CRP and WBC peaks and lower Hgb levels. On 1 and 6-month follow-up anemia, higher CRP and WBC count were related to worse outcome. Conclusion: Based on our results, there is a correlation between lower Hgb level, higher WBC count and VS. WBC count, CRP and Hgb levels may serve as early indicators of outcome. Disclosure: Nothing to disclose.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok konferenciacikk folyóiratcikk
Megjelenés:	European Journal of Neurology. - 30 : Suppl. 1 (2023), p. 319. -
További szerzők:	Kóti Nikolett (1998-) (orvostanhallgató) Gál Judit (1977-) (aneszteziológiai és ITO szakorvos) Fülesdi Béla (1961-) (aneszteziológus) Molnár Csilla (1962-) (aneszteziológus)
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