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001-es BibID:	BIBFORM085976
Első szerző:	Farkas Etelka (vegyész)
Cím:	Factors affecting the metal ion-hydroxamate interactions: effect of the position of the peptide function in the connecting chain on the Fe(III), Mo(VI) and V(V) complexation of some new desferrioxamine B (DFB) model dihydroxamic acids / Etelka Farkas, Péter Buglyó, Éva A. Enyedy, Veronika A. Gerlei, Amelia M. Santos
Dátum:	2002
ISSN:	0020-1693
Megjegyzések:	Three new dihydroxamic acids (HO(CH3)NCO (CH2) x CO NH (CH2) y CON(CH3)OH, where the related x and y values are as follows: 2,5; 3,4 and 3,3) with different length of the connecting chains containing the peptide group in different positions between the two functional groups were synthesized and their complexation with Fe(III), Mo(VI) and V(V) were studied by pH-potentiometric and spectrophotometric methods. Both the structure and length of the connecting chain in the 2,5-dihydroxamic acid (2,5-DIHA) are the same as those in the natural siderophore, desferrioxamine B (DFB). Although the stability of the monochelated complexes formed with all three dihydroxamic acids are similar, 2,5-DIHA forms significantly more stable bis-chelated complexes than the other two ligands with the three metal ions studied. The results support the hypothesis that the arrangement of the two chelating functions in 2,5-DIHA is in a proper preorganization for the coordination in octahedral complexes to metal ions having similar ionic radius as iron(III) has.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Dihydroxamic acids Fe(III) Mo(VI) and V(V) complexes Desferrioxamine B models
Megjelenés:	Inorganica Chimica Acta. - 339 (2002), p. 215-223. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Enyedy Éva Anna (1975-) (vegyész) Gerlei Veronika A. Santos, Amelia M.
Pályázati támogatás:	T034674 OTKA
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001-es BibID:	BIBFORM084879
Első szerző:	Farkas Etelka (vegyész)
Cím:	Factors affecting the metal ion-hydroxamate interactions II: effect of the length of the connecting chain on the Fe(III), Mo(VI) and V(V) complexation of some new desferrioxamine B (DFB) model dihydroxamic acids / Farkas Etelka, Buglyó Péter, Enyedy Éva A., M. Amelia Santos
Dátum:	2004
ISSN:	0020-1693
Megjegyzések:	Three new dihydroxamic acids (HO(CH3)NCO?(CH2)2?CO?NH?(CH2)x?CON(CH3)OH where the x values are 4; 3 and 2, and the compounds are abbreviated as 2,4-DIHA, 2,3-DIHA and 2,2-DIHA), containing the peptide group in a certain position to one of the two functional groups and in different distances to the other one, were synthesized and their complexation with Fe(III), Mo(VI) and V(V) was studied by pH-potentiometric, spectrophotometric and in some cases by CV methods to evaluate the redox behaviour of the Fe(III) complexes and assess their potential biological activity as siderophore models. All these compounds are structural models for the natural siderophore, desferrioxamine B (DFB). The results were compared to those of the complexes of 2,5-DIHA having the same connecting chain structure and length as DFB has, and the effects of the length of the connecting chain on the co-ordination mode and on the stability of the complexes formed were evaluated. Very similar stability of the mono-chelated complexes formed with all these dihydroxamic acids was found. All the results obtained suggest that one dihydroxamic acid (even the 2,2-DIHA) is able to complete the four coordination sites of a MoO 2? 2 core forming simple mononuclear complexes. Favoured monomeric structures of the bis-chelated complexes of these dihydroxamic acids are also suggested with V(V) having the smallest ionic radius among the three metal ions studied. In the case of iron(III), however, clear indication was obtained for the slightly different complexation behaviour of 2,2-DIHA. Namely, the formation of the mononuclear bis-chelated complex with this shortest ligand seems to have sufficient strain to induce the formation of bimetallic species such as [Fe(2,2-DIHA)2Fe)]2?. 2004 Elsevier B.V. All rights reserved.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Dihydroxamic acids Fe(III) Mo(VI) and V(V) complexes Desferrioxamine B models
Megjelenés:	Inorganica Chimica Acta. - 357 : 9 (2004), p. 2451-2461. -
További szerzők:	Buglyó Péter (1965-) (vegyész) Enyedy Éva Anna (1975-) (vegyész) Santos, Amelia M.
Pályázati támogatás:	T034674 OTKA TS 040685 OTKA
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001-es BibID:	BIBFORM089447
035-os BibID:	(cikkazonosító)110963 (WoS)000528628200017 (Scopus)85076831661
Első szerző:	Kozsup Máté (Okleveles vegyész)
Cím:	Synthesis, characterization and albumin binding capabilities of quinizarin containing ternary cobalt(III) complexes / Kozsup Máté, Dömötör Orsolya, Nagy Sándor, Farkas Etelka, Enyedy Éva A., Buglyó Péter
Dátum:	2020
ISSN:	0162-0134 1873-3344
Megjegyzések:	Four Co(III) ternary complexes with the composition of [(Co(4 N))2(quin)](ClO4)4 or [(Co(4 N))2(quinS)](ClO4)3, where 4 N =tris(2aminoethyl)amine (tren) or tris(2-pyridylmethyl)amine (tpa), quinH2 = quinizarin (1,4-dihydroxy-9,10-anthraquinone), quinSH3 = quinizarin-2-sulfonic acid (1,4-dihydroxy-9,10-anthraquinone2-sulfonic acid), were synthesized, characterized and their human serum albumin (HSA) binding capabilities were also tested. The complexes can be considered as likely chaperons of quinizarins which are structural models for anthracycline-based anticancer drugs like doxorubicin. All the Co(III) complexes are dinuclear and were isolated as mixture of isomers. Comparison of the cyclic voltammograms of the free ligands and the appropriate Co(III) complexes revealed that the new signals belonging to reversible processes in the range ?400?0 mV (vs. Ag/AgCl) for the complexes can be attributed to the reversible reduction of the Co(III) centre. These potentials are in the range of typical (O,O) chelated Co(III) ternary complexes bearing 4 N donor ligands and follow the order being more positive for the tpa containing complexes. Presence of the sulfonate group in the quinizarin results in slightly more negative reduction potential of the Co(III) complexes. HSA binding capabilities of the quinH2 and quinSH3 ligands as well as the appropriate complexes showed that quinSH3 has higher affinity to the protein than quinH2 while none of the complexes seem to bind to HSA.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal of Inorganic Biochemistry. - 204 (2020), p. 1-9. -
További szerzők:	Dömötör Orsolya Nagy Sándor (1993-) (vegyész) Farkas Etelka (1948-) (vegyész) Enyedy Éva Anna (1975-) (vegyész) Buglyó Péter (1965-) (vegyész)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP OTKA-112317 OTKA Egyéb GINOP ÚNKP19-3-I-DE-45 Egyéb ÚNKP19-3-I-DE-56 Egyéb
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001-es BibID:	BIBFORM089449
035-os BibID:	(WoS)000538134300009 (Scopus)85085646741
Első szerző:	Kozsup Máté (Okleveles vegyész)
Cím:	Synthesis and characterisation of Co(III) complexes of N-formyl hydroxylamines and antibacterial activity of a Co(III) peptide deformylase inhibitor complex / Máté Kozsup, Donal M. Keogan, Deirdre Fitzgerald-Hughes, Éva A. Enyedy, Brendan Twamley, Péter Buglyó, Darren M. Griffith
Dátum:	2020
ISSN:	1477-9226
Megjegyzések:	The X-ray crystal structure and pKa values of GSK322 a well-known and effective peptide deformylase inhibitor and antibacterial drug candidate are reported. The first examples of Co(III) complexes of N-formyl hydroxylamines are reported. Reaction of N-hydroxy-N-phenylformamide (HFA) with [Co(tren)Cl2]Cl and [Co(tpa)Cl2]Cl (where tren = tris(2- aminoethyl)amine, tpa = tris(2-pyridylmethyl)amine) with one equivalent of NaOH in H2O afforded [Co(tren)(HFA1H)](PF6)1.5Cl0.5 (1) and [Co(tpa)(HFA-1H)]Cl2 (2), respectively. X-ray crystal structures of both complexes revealed that the Nformyl hydroxylamine group acts as a bidentate ligand, coordinating the Co(III) centres via the carbonyl oxygen and deprotonated hydroxy group (O,O'), a coordination mode typically observed for closely related mono-deprotonated hydroxamic acids. Reaction of the N-formyl hydroxylamine-based GSK322 with [Co(tpa)Cl2]Cl afforded the corresponding Co(III) chaperone complex of the peptide deformylase inhibitor, [Co(tpa)(GSK322-1H)](PF6)2. GSK322 and [Co(tpa)(GSK322- 1H)](PF6)2 exhibited better Gram-positive activity than Gram-negative, where low MICs (1.56 ? 6.25 ?M) were determined for S. aureus strains, independent of their antibiotic susceptibility.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Dalton Transactions. - 49 : 21 (2020), p. 6980-6988. -
További szerzők:	Keogan, Donal M. Fitzgerald-Hughes, Deirdre Enyedy Éva Anna (1975-) (vegyész) Twamley, Brendan Buglyó Péter (1965-) (vegyész) Griffith, Darren M.
Pályázati támogatás:	GINOP-2.3.2-15-2016-00008 GINOP OTKA-112317 OTKA
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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