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001-es BibID:	BIBFORM079551
035-os BibID:	(Scopus)85029739412 (WOS)000412754700010 (PMID)28939958
Első szerző:	Hermenean, Anca
Cím:	Biochemical, Histopathological and Molecular Responses in Gills of Leuciscus cephalus Exposed to Metals / Anca Hermenean, Georgiana Gheorghiu, Miruna Silvia Stan, Hildegard Herman, Bianca Onita, Doru Puiu Ardelean, Aurel Ardelean, Mihály Braun, Miklós Zsuga, Sándor Kéki, Marieta Costache, Anca Dinischiotu
Dátum:	2017
ISSN:	0090-4341
Megjegyzések:	Gills are major targets for acute metal toxicity in fish, due to their permanent contact with aquatic pollutants. To assess the effects of metals on gills of the Leuciscus cephalus (chub), fish individuals were collected from two sites in the Tur River, Romania, in upstream (site 1) and downstream (site 2) of a metal pollution source. Quantitative and hyperspectral analyses showed that Zn, Sr, and Fe concentrations were significantly higher in gills from site 2 compared with site 1. Malondialdehyde and advanced oxidation protein products levels increased 17 and 28%, respectively, whereas reduced glutathione level diminished significantly in the gills of fish collected from site 2 compared to site 1. The activities of superoxide dismutase, catalase, and glutathione-S-transferase increased significantly at 41, 21, and 28%, respectively. Proliferating cell nuclear antigen (PCNA) protein levels, as well as the amount of DNA damage, were significantly increased for site 2 compared with site 1. The induced oxidative stress generated hyperplasia, hypertrophy, and inflammation in the epithelial cells and apoptosis. Hence, this could suggest that gill cells have tried to counteract the oxidative stress-induced DNA fragmentation by PCNA upregulation, but the PCNA expression decreased on longer time due to the low level of GSH, resulting in apoptosis.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Archives Of Environmental Contamination And Toxicology. - 73 : 4 (2017), p. 607-618. -
További szerzők:	Gheorghiu, Georgiana Stan, Miruna Herman, Hildegard Onita, Bianca Puiu Ardelean, Doru Ardelean, Aurel Braun Mihály (1966-) (vegyész, analitikus) Zsuga Miklós (1944-) (polimer kémikus) Kéki Sándor (1964-) (polimer kémikus) Costache, Marieta Dinischiotu, Anca
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001-es BibID:	BIBFORM058167
035-os BibID:	(Scopus)84927934914 (WoS)000354077300023
Első szerző:	Hermenean, Anca
Cím:	Antioxidant and hepatoprotective activity of milk thistle (Sylibum marianum L. Gaertn.) seed oil / Anca Hermenean, Miruna Stan, Aurel Ardelean, Luminiţa Pilat, Ciprian Valentin Mihali, Cristina Popescu, Lajos Nagy, György Deák, Miklós Zsuga, Sándor Kéki, Ildikó Bácskay, Ferenc Fenyvesi, Marieta Costache, Anca Dinischiotu, Miklós Vecsernyés
Dátum:	2015
ISSN:	2391-5412
Megjegyzések:	This study has assessed the protective efficacy of Silybum marianum seed oil (SMSO) in the context of CCl4-induced injury and oxidative stress in murine liver. Based on the GC-MS analysis, linoleic and stearic acids, tocopherol, ascorbic acid 2,6 dihexadecanoate and other constituents were identified in SMSO. Swiss mice received oral doses of SMSO daily for 21 days (10 g/kg b.w.) and subsequently injected i.p. with CCl4 (50% v/v in olive oil; 1 ml/kg) on the 22nd day. CCl4 administration induced an elevation of serum amino- and glutamyl transferases activities and an increased peroxidation, as well as a decrease of SOD, CAT, GPx, GR and GST activities in liver. SMSO successfully prevented oxidative stress and restored the biochemical parameters, hepatic architecture and expression of TNF-alpha. These findings suggest that SMSO was effective in counteracting the damaging effects of CCl4-induced injury in hepatocytes, probably due to its inherent antioxidant properties.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Open Life Sciences. - 10 (2015), p. 147-158. -
További szerzők:	Stan, Miruna Ardelean, Aurel Pilat, Luminiţa Mihali, Ciprian Popescu, Cristina Nagy Lajos (1979-) (vegyész) Deák György (1954-) (polimer kémikus) Zsuga Miklós (1944-) (polimer kémikus) Kéki Sándor (1964-) (polimer kémikus) Bácskay Ildikó (1969-) (gyógyszerész, gyógyszertechnológus) Fenyvesi Ferenc (1977-) (gyógyszerész, gyógyszertechnológus) Costache, Marieta Dinischiotu, Anca Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus)
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001-es BibID:	BIBFORM106882
035-os BibID:	(Wos)000649898100001 (Scopus)85105187234
Első szerző:	Onita, Mladin Bianca
Cím:	Correlation between Heavy Metal-Induced Histopathological Changes and Trophic Interactions between Different Fish Species / Bianca Onita (Mladin), Paul Albu, Hildegard Herman, Cornel Balta, Vasile Lazar, Andras Fulop, Edina Baranyai, Sándor Harangi, Sandor Keki, Lajos Nagy, Tibor Nagy, Vilmos Józsa, Dénes Gál, Károly Györe, Miruna Stan, Anca Hermenean, Anca Dinischiotu
Dátum:	2021
ISSN:	2076-3417
Megjegyzések:	This study assessed the distribution of heavy metals in the gills, kidney, and liver, correlated with the severity of histopathological changes, of three fish species with different feeding habitats (Barbus barbus, Squalius cephalus, and Chondrostoma nasus) from the Cri?ul Negru river, Romania. The levels of copper (Cu), chromium (Cr), cadmium (Cd), lead (Pb), and zinc (Zn) in fish tissues were measured by atomic absorption spectrophotometry. Histopathology and the expressions of TNF-? and proliferation cell nuclear antigen (PCNA) were investigated by immunohistochemistry and Western blot. Our data suggest a significant correlation between the bioconcentration level of metals and structural changes. The carnivorous species was the most affected compared to the omnivorous and herbivorous ones, and the most affected organ was the kidney. Moreover, the correlation of tissue damage with the PCNA and TNF-? expression levels revealed that the herbivorous species presented less extended lesions, likely due to higher activated repair mechanisms and lower levels of inflammation. In conclusion, our data and the subsequent statistical analysis suggest that feeding behavior could be correlated with the histopathological alterations and might be used for a more profound evaluation of aquatic environment safety and analysis of aquatic ecosystems.
Tárgyszavak:	Természettudományok Kémiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk fish metals bioaccumulation gills kidney liver histopathology trophic interactions
Megjelenés:	Applied Sciences-Basel. - 11 : 9 (2021), p. 3760-3774. -
További szerzők:	Albu, Paul Herman, Hildegard Balta, Cornel Lazar, Vasile Fülöp András Baranyai Edina (1987-) (környezetkutató) Harangi Sándor (1987-) (vegyész) Kéki Sándor (1964-) (polimer kémikus) Nagy Lajos (1979-) (vegyész) Nagy Tibor (1988-) (vegyész) Józsa Vilmos Gál Dénes Györe Károly Stan, Miruna Hermenean, Anca Dinischiotu, Anca
Pályázati támogatás:	10PCCF/-PN-III-P4-ID-PCCF2016-0114-RADAR Egyéb
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