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001-es BibID:	BIBFORM038613
035-os BibID:	PMID:2272539
Első szerző:	Bányai Anikó
Cím:	Complement-mediated immune complex solubilization and precipitation inhibition in sera of patients with non-Hodgkin's lymphoma / Bányai A., Pálóczi K., Csípő I., Csongor J., Szegedi Gy.
Dátum:	1990
ISSN:	0017-6559
Megjegyzések:	The complement functions of 42 patients with non-Hodgkin's lymphoma have been examined. The patients were divided into groups according to the severity of their disease: 1st--patients with high-grade lymphomas, 2nd--with low-grade lymphomas and 3rd--with chronic lymphocytic leukaemia. The adopted methods were the measurements of complement-mediated immune complex solubilizing capacity (CMSC) and the complement-mediated immune complex precipitation inhibition capacity (IPIC). The CMSC and IPIC values were examined parallel with CH50, C3 complement levels and with levels of circulating immune complexes (CIC) in the sera of patients. The results indicated that the acquired deficiency of complement functions could be established by CMSC and IPIC measurements in the sera of patients with high-grade lymphomas. These defects were found to be milder in the group with low-grade lymphomas, and were not detectable in CLL. The changes of CH50 levels were found to be similar to that of IPIC values and the decrease in C3 levels was detectable in high-grade and low-grade lymphomas too. Elevated CIC levels were found in those cases in which both CMSC and IPIC were decreased.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Haematologia. - 23 : 2 (1990), p. 87-95. -
További szerzők:	Pálóczy Katalin Csongor József Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Csípő István (1953-) (vegyész)
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001-es BibID:	BIBFORM038629
035-os BibID:	PMID:9272279
Első szerző:	Csípő István (vegyész)
Cím:	Serum complement activation of SLE patients during plasmapheresis / Csipő I., Kávai M., Kiss E., Bedő Z., Csongor J., Szegedi Gy., Philbert F., Cohen J. H.
Dátum:	1997
ISSN:	0891-6934
Megjegyzések:	The erythrocyte complement receptor 1 (ECR1)-immune complex binding assay is a sensitive method for the determination of complement fragments which can be activated by bovine serum albumin (BSA)-anti-BSA in vitro. When the C3b/C4b containing bovine serum albumin (BSA)-anti-BSA was formed in the presence of the serum of patients with systemic lupus erythematosus (SLE) its binding to ECR1 was found to be lower than that formed in sera of normal volunteers. The plasmapheresis of SLE patients homozygous for the CR1/E high density allele displays a beneficial effect on the formation of C3b/C4b containing BSA-anti-BSA and its binding to ECR1. There was no significant correlation between the serum C3/C4 level and the percentage of C3b/C4b containing BSA-anti-BSA binding to the ECR1 of SLE patients during plasmapheresis. At the same time, there was an inverse correlation between the serum immune complex level and the ECR1 binding, which was significant in 3 of 5 cases. These data suggest that, besides the determination of different components of complement activation, the functional assay of complement activation might be useful in monitoring the effect of plasmapheresis in SLE.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény 0 (Antibodies) 0 (Antigen-Antibody Complex) 0 (Receptors, Complement 3b) 0 (Serum Albumin, Bovine) 80295-43-8 (Complement C3b) 80295-50-7 (Complement C4b) Adult Animals Antibodies/immunology Antigen-Antibody Complex/blood Cattle Complement Activation/immunology Complement C3b/immunology Complement C4b/immunology Erythrocytes/immunology Female Humans Lupus Erythematosus, Systemic/blood/immunology Male Middle Aged Plasmapheresis Receptors, Complement 3b/immunology Serum Albumin, Bovine/immunology
Megjelenés:	Autoimmunity. - 25 : 3 (1997), p. 139-146. -
További szerzők:	Kávai Mária (1930-) (vegyész) Kiss Emese (1960-) (belgyógyász, immunológus) Bedő Zoltán Csongor József Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Philbert, F. Cohen, J. H. M.
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001-es BibID:	BIBFORM038563
Első szerző:	Kávai Mária (vegyész)
Cím:	Defective immune complex degradation by monocytes in patients with systemic lupuserythematosus / Kavai M., Csipo I., Sonkoly, I., Csongor J., Szegedi Gy.
Dátum:	1986
ISSN:	0300-9475
Megjegyzések:	The binding of 125I-labelled anti-bovine serum albumin (BSA)-BSA immune complexes(IC), giving a final molar antibody to antigen ratio of 1:1, to monocytesisolated from 18 patients with systemic lupus erythematosus (SLE) and from 10normal healthy donors was quantitatively investigated. The degradation of thebound IC by the same monocytes was kinetically determined at the same time. Theassays were performed on monocyte monolayers. Scatchard plots at 4 degrees Cdemonstrated that monocytes from patients with active SLE expressed a mean Fcgamma receptor (FcR) number that was 22% higher than that of the controls,although this did not reach statistical significance. The FcR number of normalmonocytes and the degradation rate of anti-BSA-BSA complexes by the same cellsshowed a positive correlation. At the same time, the digestion of anti-BSA-BSAcomplexes by monocytes of SLE patients with active disease was prolonged, despitetheir enhanced FcR-ligand binding. The dissociation of FcR-ligand binding andFcR-mediated degradation suggests that the IC degradation is controlled byaltered biochemical mechanisms in the monocytes of SLE patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Scandinavian Journal Of Immunology. - 24 : 5 (1986), p. 527-532. -
További szerzők:	Csípő István (1953-) (vegyész) Sonkoly Ildikó Csongor József Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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