Találati lista | Tudóstér

001-es BibID:	BIBFORM132164
Első szerző:	Al Ashkar, Habib (népegészségügyi szakember)
Cím:	Association of HDL-C and its subfraction profile with heart rate response to exercise / Al Ashkar Habib, Kovács Nóra, Veres-Balajti Ilona, Seres Ildikó, Paragh György, Ádány Róza, Pikó Péter
Dátum:	2025
ISSN:	0021-9150
Megjegyzések:	Background and Aims: High-density lipoproteins (HDL) are a heterogeneous group of plasma molecules that can be divided into subfractions based on their characteristics. Although HDL subfractions vary widely in size, density, and function, their association with cardiovascular outcomes remains complex and partly unknown. Heart rate response to physical activity (HRR) is a well-known indicator of individual cardiovascular fitness. The present study aimed to investigate the association between HRR and HDL subfraction profile in 304 individuals from the Hungarian population. Methods: HDL was divided into ten subfractions using the Lipoprint HDL? system. The YMCA 3-minute step test was used to assess the individual HRR by measuring the heart rate at four-time points: before the exercise (resting HR - HRrest), immediately (HRexe), 5 minutes (HR5min) and 10 minutes (HR10min) after exercise. In addition, acute HRR (?HR) was calculated (HRexe-HRrest). Multiple linear regression was used to examine the association between HDL subfraction profile and HRR. Results: The distribution of HDL-3 (BHRexe=-1.26, p =0.020; BHR5min=-0.70, p=0.048; B?HR=-1.21, p=0.035), HDL-4 (BHRexe=-1.86, p=0.040; BHR5min=-0.92, p=0.048; B?HR=-1.88, p=0.030), and HDL-5 (BHRexe=-3.34, p=0.017; BHR5min=-1.84, p=0.041; B?HR=-3.32, p=0.037) showed a significant negative association, whereas HDL-7 (BHRexe=2.64, p=0.025; BHR5min=1.37, p=0.045; B?HR=2.41, p=0.034), HDL-8 (BHRexe=2.87, p =0.030; BHR5min=1.70, p=0.035; B?HR=2.48, p=0.035), HDL-9 (BHRexe=3.10, p =0.010; BHR5min=2.18, p=0.013; B?HR=3.04, p=0.045), and HDL-10 (BHRexe=0.95, p =0.035; BHR5min=0.67, p=0.020; B?HR=0.71, p=0.049) were positively associated with HRR. However, there was no significant change in the concentration of HDL-C and its subfractions in mmol/L in relation to HRR. Conclusions: Our results suggest that a more optimal (smaller) heart rate change in response to physical activity is associated with a more favourable distribution of the HDL subfraction profile, i.e. a significant increase in the proportion of smaller HDL subfractions and a decrease in the proportion of larger subfractions. In contrast, no significant quantitative changes were observed in HDL-C and its subfractions.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk HDL Cardiovascular risk heart rate response to exercise HDL-C subfraction profile Cardiorespiratory fitness Lipid profile
Megjelenés:	Atherosclerosis. - 407 : Suppl. (2025), p. 57. -
További szerzők:	Kovács Nóra (1989-) (népegészségügyi szakember) Veres-Balajti Ilona (1965-) (gyógytornász, egészségfejlesztő) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos) Pikó Péter (1987-) (biológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM132222
Első szerző:	Pikó Péter (biológus)
Cím:	Effect of smoking and its exposure on the HDL subfraction profile / Pikó Péter, Al Ashkar Habib, Helu Nihad Kharrat, Kovács Nóra, Pál László, Szücs Sándor, Seres Ildikó, Paragh György, Ádány Róza
Dátum:	2025
ISSN:	0021-9150
Megjegyzések:	Background and Aims: Smoking is a preventable risk factor for cardiovascular disease (CVD) and other non-communicable diseases. Studies have shown that smoking reduces high-density lipoprotein cholesterol (HDL-C) and increases triacylglycerol (TG) levels, thereby increasing the risk of developing atherosclerosis. The aim of the present study was to investigate the effects of smoking and smoking exposure on lipidomic profiles (total cholesterol (TC), HDL-C, TG, LDL, apoA-I, and apoB-100), focusing on HDL subfractions, in 137 nonsmokers and 177 smokers from the Hungarian population. Methods: The HDL was separated using the Lipoprint HDL? system, which identifies ten subfractions (HDL-1? 10) and three subclasses: large (HDL-L), intermediate (HDL-I), and small (HDL-S). Four outcome variables were used to assess smoking exposure: current smoking status, number of cigarettes per day (CPD), duration of smoking (DoS), and heaviness of smoking index (HSI). Multivariate linear regression and receiver operating characteristic (ROC) curve analysis were used, and p-values adjusted by the Benjamini-Hochberg method <0.05 were considered significant. Results: Smoking and its exposures significantly reduced HDL-C and apoA-I levels, while increasing the TG levels and the TG/HDL-C and apoA-I/apoB-100 ratios. Significant reductions in concentrations were observed between smoking and HDL-2 to HDL-8, and between CPD and HDL-3 to HDL-9 and all subclasses. Similarly, significant reductions were observed between DoS and HDL-4 to HDL-7 andHDL-I, and between HSI and HDL-3 to HDL-10 and HDL-I to HDL-S. Despite the quantitative changes, smoking did not significantly modify the distribution of the subfractions and subclasses. Conclusions: Our results confirm that smoking adversely alters the lipid profile and significantly reduces the levels of almost all HDL subfractions , especially HDL 5,-6 and-7 and HDL-I, thereby accelerating the development of atherosclerosis.
Tárgyszavak:	Orvostudományok Egészségtudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Atherosclerosis. - 407 : Suppl. (2025), p. 56-57. -
További szerzők:	Al Ashkar, Habib (1998-) (népegészségügyi szakember) Helu, Nihad Kharrat (1992-) (PhD hallgató) Kovács Nóra (1989-) (népegészségügyi szakember) Pál László (1987-) (népegészségügyi szakember, egészségfejlesztő) Szűcs Sándor (1958-) (biokémikus, vegyész) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM114677
035-os BibID:	(scopus)85164039480 (wos)001015071200001
Első szerző:	Pikó Péter (biológus)
Cím:	Association of CETP Gene Polymorphisms and Haplotypes with Cardiovascular Risk / Piko Peter, Jenei Tibor, Kosa Zsigmond, Sandor Janos, Kovacs Nora, Seres Ildiko, Paragh Gyorgy, Adany Roza
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Cholesteryl ester transfer protein (CETP) is known to influence HDL-C levels, potentially altering the profile of HDL subfractions and consequently cardiovascular risk (CVR). This study aimed to investigate the effect of five single-nucleotide polymorphisms (SNPs; rs1532624, rs5882, rs708272, rs7499892, and rs9989419) and their haplotypes (H) in the CETP gene on 10-year CVR estimated by the Systematic Coronary Risk Evaluation (SCORE), the Framingham Risk Score for Coronary Heart Disease (FRSCHD) and Cardiovascular Disease (FRSCVD) algorithms. Adjusted linear and logistic regression analyses were used to investigate the association of SNPs and 10 haplotypes (H1-H10) on 368 samples from the Hungarian general and Roma populations. The T allele of rs7499892 showed a significant association with increased CVR estimated by FRS. H5, H7, and H8 showed a significant association with increased CVR based on at least one of the algorithms. The impact of H5 was due to its effect on TG and HDL-C levels, while H7 showed a significant association with FRSCHD and H8 with FRSCVD mediated by a mechanism affecting neither TG nor HDL-C levels. Our results suggest that polymorphisms in the CETP gene may have a significant effect on CVR and that this is not mediated exclusively by their effect on TG and HDL-C levels but also by presently unknown mechanisms.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Framingham Risk Score HDL subfraction profile Systematic Coronary Risk Evaluation cholesteryl ester transfer protein haplotype high-density lipoprotein cholesterol single-nucleotide polymorphism
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 12 (2023), p. 1-16. -
További szerzők:	Jenei Tibor (1963-) (programtervező informatikus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP 135784 OTKA TK2016-78 Egyéb TKCS-2021/32 Egyéb ÚNKP-22-4-II-DE-268 Egyéb RRF-2.3.1-21-2022-00006 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM114678
035-os BibID:	(scopus)85170209245 (wos)001060602800001
Első szerző:	Pikó Péter (biológus)
Cím:	Association of HDL Subfraction Profile with the Progression of Insulin Resistance / Piko Peter, Jenei Tibor, Kosa Zsigmond, Sandor Janos, Kovacs Nora, Seres Ildiko, Paragh Gyorgy, Adany Roza
Dátum:	2023
ISSN:	1422-0067
Megjegyzések:	Type 2 diabetes mellitus (T2DM) is a major global public health problem, as it is associated with increased morbidity, mortality, and healthcare costs. Insulin resistance (IR) is a condition characterized by disturbances in carbohydrate and lipid metabolism that precedes T2DM. The aim of the present study was to investigate the association between HDL and its subfraction profile and the progression of IR, as assessed by the Homeostatic Model Assessment for IR (HOMA-IR) index, and to define cut-off values to identify an increased risk of IR. Individuals with a HOMA-IR greater than 3.63 were considered to have IR. The HDL subfractions were separated using the Lipoprint system, which identifies ten subfractions (HDL-1-10) in three subclasses as large (HDL-L), intermediate (HDL-I) and small (HDL-S). Analyses were performed on samples from 240 individuals without IR and 137 with IR from the Hungarian general and Roma populations. The HDL-1 to -6 subfractions and the HDL-L and -I classes showed a significant negative association with the progression and existence of IR. Among them, HDL-2 (B = -40.37, p = 2.08 ? 10-11) and HDL-L (B = -14.85, p = 9.52 ? 10-10) showed the strongest correlation. The optimal threshold was found to be 0.264 mmol/L for HDL-L and 0.102 mmol/L and above for HDL-2. Individuals with HDL-L levels below the reference value had a 5.1-fold higher risk of IR (p = 2.2 ? 10-7), while those with HDL-2 levels had a 4.2-fold higher risk (p = 3.0 ? 10-6). This study demonstrates that the HDL subfraction profile (especially the decrease in HDL-2 and -L) may be a useful marker for the early detection and intervention of atherogenic dyslipidemia in subjects with impaired glucose and insulin metabolism.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk insulin resistance HDL subfraction profile HDL-2 large HDL cut-off points HOMA-IR diabetes high-density lipoprotein cholesterol
Megjelenés:	International Journal Of Molecular Sciences. - 24 : 17 (2023), p. 1-13. -
További szerzők:	Jenei Tibor (1963-) (programtervező informatikus) Kósa Zsigmond (1953-) (orvos) Sándor János (1966-) (orvos-epidemiológus) Kovács Nóra (1989-) (népegészségügyi szakember) Seres Ildikó (1954-) (biokémikus) Paragh György (1953-) (belgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	GINOP-2.3.2-15-2016-00005 GINOP 135784 OTKA TK2016-78 Egyéb TKCS-2021/32 Egyéb ÚNKP-22-4-II-DE-268 Egyéb RRF-2.3.1-21-2022-00006 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon: