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1.

001-es BibID:BIBFORM123634
035-os BibID:(Scopus)85202894122 (WoS)001303621600001
Első szerző:Esze Regina (általános orvos)
Cím:C-peptide : an essential ally in microvascular complications of type 2 diabetes mellitus and obesity / Regina Esze, Sándor Barna, Péter Fülöp, Péter Kempler, Márton Mikó, Dénes Páll, György Paragh, Sándor Somodi, Miklós Emri, Zita Képes, Ildikó Garai, Miklós Káplár
Dátum:2024
ISSN:1758-5996
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Diabetology & Metabolic Syndrome. - 16 : 1 (2024). -
További szerzők:Barna Sándor (1982-) (kutató orvos) Fülöp Péter (1974-) (belgyógyász, endokrinológus, lipidológus) Kempler Péter (1954-) (belgyógyász, diabetológus) Mikó Márton (1990-) Páll Dénes (1967-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász) Somodi Sándor (1977-) (belgyógyász) Emri Miklós (1962-) (fizikus) Képes Zita (1991-) (orvos) Garai Ildikó (1966-) (radiológus) Káplár Miklós (1965-) (belgyógyász, diabetológus)
Pályázati támogatás:GINOP-2.1.1-15-2015- 00609
GINOP
TKP2021-NKTA-34
Egyéb
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2.

001-es BibID:BIBFORM101055
035-os BibID:(WoS)000809900700015 (Scopus)85131251193
Első szerző:Molnár Ágnes (gyógytornász)
Cím:Change of fibroblast growth factor 21 level correlates with the severity of diabetic sensory polyneuropathy after six-week physical activity / Ágnes Molnár, Anita Szentpéteri, Hajnalka Lőrincz, Ildikó Seres, Mariann Harangi, Zoltán Balogh, Péter Kempler, György Paragh, Ferenc Sztanek
Dátum:2022
ISSN:1530-6550 2153-8174
Megjegyzések:Background: Diabetic neuropathy (DN) is a very frequent microvascular complication of type 2 diabetes mellitus (T2DM). Obesity and physical inactivity are well-known risk factors for T2DM. Fibroblast growth factor 21 (FGF21) is a liver-secreted hormone with several beneficial effects on obesity-related metabolic disorders. We aimed to investigate the effect of short-term physical activity on the levels of FGF21, and its correlation with the severity of peripheral sensory polyneuropathy in T2DM patients. Methods: Thirty patients with DN were enrolled in the study, compared to age- and gender-matched controls. We conducted a six-week aerobic training program, which meant treadmill and cycle ergometers three times a week. Anthropometric and laboratory parameters were measured for each patient before and after intervention. Serum levels of FGF21, TNF-alpha, irisin, leptin and adiponectin were measured by ELISA. The sensory perception threshold (CPT) was quantitatively measured using Neurometer?. Results: We found significant decreases in BMI, waist circumference, HbA1c and TNF-alpha levels. From baseline to six-week follow-up, FGF21 levels were significantly increased in DN patients. Significant negative correlations were shown between the changes in FGF21 levels and BMI, between changes in FGF21 and the improvement of CPT values, and between the changes in FGF21 and TNF-alpha levels. There was no difference in irisin, adiponectin and leptin levels in DN patients after aerobic training program. Conclusion: The physical activity may increase the level of FGF21 in T2DM patients with neuropathy. Our results highlight the importance of regular physical activity in the treatment of diabetic neuropathy.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Reviews in Cardiovascular Medicine. - 23 : 5 (2022), p. 1-10. -
További szerzők:Szentpéteri Anita (1988-) (biológus) Lőrincz Hajnalka (1986-) (biológus) Seres Ildikó (1954-) (biokémikus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Balogh Zoltán (1965-) (belgyógyász, gasztroenterológus, diabetológus) Kempler Péter (1954-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász) Sztanek Ferenc (1982-) (orvos)
Pályázati támogatás:Bridging Fund, Faculty of Medicine, University of Debrecen - HM
Egyéb
Hungarian Diabetes Association
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM094676
Első szerző:Nádró Bíborka (általános orvos)
Cím:Effects of alpha-lipoic acid treatment on serum progranulin levels and inflammatory markers in diabetic neuropathy / Bíborka Nádró, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, György Paragh, Péter Kempler, Mariann Harangi, Ferenc Sztanek
Dátum:2021
ISSN:0300-0605
Megjegyzések:Objectives: Progranulin (PGRN) is a secreted growth factor that helps to regulate neuronal survival by blocking tumor necrosis factor-alpha (TNFa) receptors. The antioxidant alpha-lipoic acid (ALA) is used in diabetic neuropathy to improve nerve conduction and relieve neuropathic pain, but its effects on PGRN levels have not yet been elucidated. Methods: In this prospective study, 54 patients with type 2 diabetes and peripheral neuropathy received 600 mg of ALA daily for 6 months. Twenty-four patients with diabetes without neuropathy were also included in the study. Serum PGRN and TNFa levels were determined using enzyme-linked immunosorbent assays. In addition, current perception threshold (CPT) testing was used to assess sensory neuropathy. Results: After ALA treatment, serum PGRN levels were significantly increased and CPT values were significantly improved. Furthermore, there were significant positive correlations among TNFa, ICAM-1, and PGRN levels both before and after ALA treatment. A significant negative correlation was observed between the improvements in CPT and the PGRN levels. Furthermore, ICAM-1 levels were an independent predictor of PGRN levels. Conclusions: Changes in serum PGRN levels indicate that ALA treatment may have beneficial effects on endothelial function and neuronal inflammation.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
diabetic neuropathy
cardiac autonomic neuropathy
progranulin
intercellular adhesion molecule-1
alpha-lipoic acid
tumor necrosis factor-alpha
type 2 diabetes
Megjelenés:Journal of International Medical Research. - 49 : 5 (2021), p. 1-13. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Molnár Ágnes (1972-) (gyógytornász) Szentpéteri Anita (1988-) (biológus) Zöld Eszter (1988-) (szemész) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Paragh György (1953-) (belgyógyász) Kempler Péter (1954-) (belgyógyász, diabetológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Sztanek Ferenc (1982-) (orvos)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
OTKA-115723
OTKA
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM122829
035-os BibID:(Scopus)85197689034 (WoS)001267636600007
Első szerző:Pető Attila (általános orvos)
Cím:Correlations between distal sensorimotor polyneuropathy and cardiovascular complications in diabetic patients in the North-Eastern region of Hungary / Attila Pető, László Imre Tóth, Marcell Hernyák, Hajnalka Lőrincz, Ágnes Molnár, Attila Csaba Nagy, Miklós Lukács, Péter Kempler, György Paragh, Mariann Harangi, Sztanek Ferenc
Dátum:2024
ISSN:1932-6203
Megjegyzések:Distal sensorimotor polyneuropathy (DSPN) is the earliest detectable and the most frequent microvascular complication in diabetes mellitus. Several studies have previously demonstrated correlations between cardiovascular risk factors in diabetic patients and independent risk factors for diabetic neuropathy. Our objective was to retrospectively analyze data from diabetic patients in the North-East region of Hungary who underwent neuropathy screening at the Diabetic Neuropathy Center, University of Debrecen, between 2017 and 2021. We aimed to investigate the correlations between cardiovascular risk factors and microvascular complications among patients with DSPN. The median age of the patients was 67 years, 59,6% were female, and 91,1% had type 2 diabetes. The prevalence of DSPN among the study subjects was 71.7%. A significantly longer duration of diabetes (p<0.01) was noted in patients with DSPN. Those with DSPN demonstrated a significantly higher HbA1c level (p<0.001) and a greater frequency of insulin use (p = 0.001). We observed a significantly elevated albumin/creatinine ratio (p<0.001) and a significantly lower eGFR (p<0.001) in patients with DSPN. Diabetic retinopathy exhibited a significantly higher prevalence in patients with DSPN (p<0.001). A higher prevalence of myocardial infarction (p<0.05), ischemic heart disease (p<0.001), peripheral arterial disease (p<0.05) and a history of atherosclerosis (p<0.05) was observed in patients with DSPN. In a multivariate logistic regression analysis, the following factors were independently associated with the presence of DSPN: higher HbA1c (OR:2.58, 95% CI:1.89?3.52, p<0.001), age (OR:1.03, 95% CI:1.01?1.05, p = 0.006), albumin/creatinine ratio above 3 mg/mmol (OR:1.23, 95% CI:1.06?1.45, p = 0.008), retinopathy (OR:6.06, 95% CI:1.33?27.53, p = 0.02), and composite cardiovascular endpoint (OR:1.95, 95% CI:1.19?3.19, p = 0.008). Our study revealed that age, elevated HbA1c levels, significant albuminuria, retinopathy, and cardiovascular complications may increase the risk of DSPN. Further investigation of these associations is necessary to understand the impact of patient characteristics during the treatment of diabetic neuropathy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:PLoS ONE. - 19 : 7 (2024), p. 1-13. -
További szerzők:Tóth László Imre Hernyák Marcell (1981-) (orvos) Lőrincz Hajnalka (1986-) (biológus) Molnár Ágnes Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Lukács Miklós (1994-) Kempler Péter (1954-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Sztanek Ferenc (1982-) (orvos)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
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5.

001-es BibID:BIBFORM136214
035-os BibID:(wos)001725035400001
Első szerző:Sztanek Ferenc (orvos)
Cím:Targeting Oxidative Stress and Mitochondrial Dysfunction in Diabetic Neuropathy : Mechanisms and Therapeutic Opportunities / Sztanek Ferenc, Tóth László Imre, Hernyák Marcell, Pető Attila, Lőrincz Hajnalka, Menyhárt Adrienn, Balogh Dóra Marietta, Nagy Attila Csaba, Kempler Peter, Paragh György, Harangi Mariann
Dátum:2026
ISSN:2076-3921
Megjegyzések:Diabetic neuropathy is a frequent and disabling complication of diabetes, encompassing distal symmetric polyneuropathy and cardiovascular autonomic neuropathy, both associated with reduced quality of life and increased cardiovascular risk. Beyond its traditional interpretation as a direct consequence of chronic hyperglycaemia, oxidative stress has emerged as a central integrative mechanism linking metabolic overload, inflammation, mitochondrial dysfunction, and microvascular injury to progressive neural damage. These processes converge within the neurovascular unit, promoting a self-perpetuating cycle of axonal degeneration, impaired nerve perfusion and altered neuronal excitability. This narrative review synthesises experimental and clinical evidence on oxidative stressrelated pathways implicated in diabetic neuropathy, including hyperglycaemia-activated metabolic routes, mitochondrial dysfunction, endoplasmic reticulum stress, and chronic inflammatory signalling. Classical antioxidant and mitochondrial-supportive interventions are evaluated alongside pleiotropic glucose-lowering agents, with particular emphasis on sodium?glucose cotransporter-2 inhibitors and glucagon-like peptide-1 receptor agonists, integrating mechanistic insights with biomarker and clinical outcome data. Conventional antioxidant strategies, such as ?-lipoic acid, acetyl-L-carnitine, coenzyme Q10 and N-acetylcysteine, show reproducible benefits on neuropathic symptoms and oxidative stress markers, but evidence for sustained structural or disease-modifying effects remains limited. In contrast, incretin-based therapies and sodium?glucose cotransporter-2 inhibitors exert broader pleiotropic actions by attenuating oxidative and inflammatory signalling, improving mitochondrial homeostasis and endothelial function, with emerging evidence for modest but consistent neurophysiological and autonomic benefits. Overall, oxidative stress emerges as a key mechanistic hub in diabetic neuropathy. Future progress will depend on mechanism-aligned, neuropathy-specific clinical trials incorporating multidimensional endpoints and validated biomarkers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
diabetic neuropathy
oxidative stress
mitochondrial dysfunction
inflammation
endothelial dysfunction
SGLT2 inhibitors
GLP-1 receptor agonists
Megjelenés:Antioxidants. - 15 : 3 (2026), p. 367-401. -
További szerzők:Tóth László (1997-) (orvos) Hernyák Marcell (1981-) (orvos) Pető Attila (1990-) (általános orvos) Lőrincz Hajnalka (1986-) (biológus) Menyhárt Adrienn Balogh Dóra Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Kempler Péter (1954-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
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6.

001-es BibID:BIBFORM131910
Első szerző:Sztanek Ferenc (orvos)
Cím:Sex Differences in Cardiovascular Risk and Diabetic Polyneuropathy : a Single-Center Retrospective Study in North-Eastern Hungary / Sztanek Ferenc, Pető Attila, Tóth László Imre, Lőrincz Hajnalka, Molnár Ágnes, Lukács Miklós, Menyhárt Adrienn, Kempler Péter, Paragh György, Harangi Mariann, Nagy Attila Csaba
Dátum:2025
ISSN:2077-0383
Megjegyzések:Background/Objectives: Diabetic sensorimotor polyneuropathy (DSPN) is a frequent microvascular complication of diabetes mellitus, associated with increased morbidity and reduced quality of life. The existing literature offers a limited understanding of sex-specific cardiovascular risk profiles and their association with DSPN, particularly within Central and Eastern European populations. Methods: A retrospective analysis was conducted using data from 621 individuals with type 1 or type 2 diabetes mellitus who underwent comprehensive neuropathy screening at the University of Debrecen between 2017 and 2021. The diagnosis of DSPN was made in accordance with international criteria, incorporating symptom scores, and electrophysiological measurements. Multivariate logistic regression was applied in order to identify independent predictors. Results: The diagnosis of DSPN was made in 444 individuals (71.5%), of whom 58.2% were female. Despite similar glycemic control (HbA1c: 7.81% in men vs. 7.65% in women, p = 0.297), men had significantly more frequent occurrences of previous myocardial infarction (11.8% vs. 5.0%, p = 0.008), peripheral vascular disease (19.9% vs. 12.7%, p = 0.041) and atherosclerosis (31.7% vs. 22.0%, p = 0.021). Multivariate analysis showed that female gender was independently associated with a lower incidence of DSPN (odds ratio [OR] = 0.592, 95% confidence interval [CI]: 0.369?0.950, p = 0.030), while diabetic retinopathy was a significant predictor (OR = 2.728, 95% CI: 1.300?5.725, p = 0.008). Electrophysiological testing revealed lower nerve conduction amplitudes in females for selected nerves. Conclusions: Our findings highlight sex-specific differences in neuropathy risk and support the implementation of individualized screening strategies in diabetic populations with region-specific risk factors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
diabetic sensorimotor polyneuropathy
cardiovascular risk factors
sex differences
type 2 diabetes mellitus
Megjelenés:Journal of Clinical Medicine. - 14 : 16 (2025), p. 1-16. -
További szerzők:Pető Attila (1990-) (általános orvos) Tóth László (1997-) (orvos) Lőrincz Hajnalka (1986-) (biológus) Molnár Ágnes (1978-) (egészségpolitikus) Lukács Miklós (1994-) Menyhárt Adrienn Kempler Péter (1954-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00009
EFOP
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM084638
035-os BibID:(WoS)001485217400004 (Scopus)105004058702
Első szerző:Sztanek Ferenc (orvos)
Cím:Effect of alpha-lipoic acid treatment on plasma asymmetric dimethylarginine, a biomarker of endothelial dysfunction in diabetic neuropathy / Ferenc Sztanek, Hajnalka Lőrincz, Ágnes Molnár, Anita Szentpéteri, Eszter Zöld, Ildikó Seres, Dénes Páll, Mariann Harangi, Péter Kempler, György Paragh
Dátum:2020
ISSN:1734-1922
Megjegyzések:Introduction: Diabetic neuropathy may develop on a background of hyperglycemia and is associated with increased oxidative stress. Elevated asymmetric dimethylarginine (ADMA) levels are linked to oxidative stress reducing the synthesis of nitric oxide (NO) by uncoupling NO synthase. Oxidative stress induces considerable changes in nerve conduction velocity in diabetic patients. There is strong evidence that alpha-lipoic acid (ALA) as an antioxidant may improve nerve conduction and relieve neuropathic symptoms. We aimed to investigate the relationship between endothelial dysfunction and NO synthesis in type 2 diabetic patients with peripheral neuropathy after ALA treatment. Materials and Methods: Fifty-four type 2 diabetic patients with neuropathy were included in the study. Serum ADMA concentration, ICAM-1, VCAM-1, oxLDL and TNF-alpha levels were determined with ELISA. NO concentration was measured by Griess reaction. Peripheral sensory nerve function was assessed by current perception threshold (CPT) testing. Autonomic function was assessed by Ewing's five standard cardiovascular reflex tests (CAS). Results: ADMA levels were significantly decreased (0.62?0.11 vs. 0.53?0.11 ?mol/l, p<0.001), as well as TNF-alpha concentrations (1.21?0.42 pg/ml vs. 1.05?0.5 pg/ml, p<0.05); while NO levels were significantly increased (16.78?11.1 vs. 21.58?8.84 ?mol/l, p<0.05) after six month of 600 mg/day ALA treatment. VCAM-1, ICAM-1 and oxLDL levels did not change significantly. The CPT and CAS significantly improved after ALA treatment. The improvement of current perception threshold values was correlated positively with the change of ADMA levels (r=0.58, p<0.001). Change in ADMA level was more pronounced in responder patients based on both CPT and CAS. Conclusions: Our results suggest that ALA supplementation improves endothelial function characterized by serum levels of ADMA and TNF-alpha in patients with diabetic neuropathy. Changes in serum ADMA levels may predict the clinical response to ALA treatment.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
diabetic neuropathy
cardiac autonomic neuropathy
nitric oxide
asymmetric dimethylarginine
alpha-lipoic acid
Megjelenés:Archives of Medical Science. - 2020 (2020), p. 1-9. -
További szerzők:Lőrincz Hajnalka (1986-) (biológus) Molnár Ágnes (1972-) (gyógytornász) Szentpéteri Anita (1988-) (biológus) Zöld Eszter (1988-) (szemész) Seres Ildikó (1954-) (biokémikus) Páll Dénes (1967-) (belgyógyász, kardiológus) Harangi Mariann (1974-) (belgyógyász, endokrinológus) Kempler Péter (1954-) (belgyógyász, diabetológus) Paragh György (1953-) (belgyógyász)
Pályázati támogatás:OTKA-115723
OTKA
EFOP-3.6.2-16-2017-00009
EFOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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