Találati lista | Tudóstér

001-es BibID:	BIBFORM001013
Első szerző:	Peters, Eva M.J.
Cím:	Probing the effects of stress mediators on the human hair follicle / Peters E.M.J., Liotiri S., Bodó E., Hagen E., Bíró T., Arck P.C., Paus R.
Dátum:	2007
Megjegyzések:	Stress alters murine hair growth, depending on substance P-mediated neurogenic inflammation and nerve growth factor (NGF), a key modulator of hair growth termination (catagen induction). Whether this is of any relevance in human hair follicles (HFs) is completely unclear. Therefore, we have investigated the effects of substance P, the central cutaneous prototypic stress-associated neuropeptide, on normal, growing human scalp HFs in organ culture. We show that these prominently expressed substance P receptor (NK1) at the gene and protein level. Organ-cultured HFs responded to substance P by premature catagen development, down-regulation of NK1, and up-regulation of neutral endopeptidase (degrades substance P). This was accompanied by mast cell degranulation in the HF connective tissue sheath, indicating neurogenic inflammation. Substance P down-regulated immunoreactivity for the growth-promoting NGF receptor (TrkA), whereas it up-regulated NGF and its apoptosis- and catagen-promoting receptor (p75NTR). In addition, MHC class I and beta2-microglobulin immunoreactivity were up-regulated and detected ectopically, indicating collapse of the HF immune privilege. In conclusion, we present a simplistic, but instructive, organ culture assay to demonstrate sensitivity of the human HF to key skin stress mediators. The data obtained therewith allow one to sketch the first evidence-based biological explanation for how stress may trigger or aggravate telogen effluvium and alopecia areata.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	The American Journal of Pathology. - 171 : 6 (2007), p. 1872-1886. -
További szerzők:	Liotiri, Sofia Bodó Enikő Hagen, Evelin Arck, Petra C. Paus, Ralf Bíró Tamás (1968-) (élettanász)
Internet cím:	elektronikus valtozat elektronikus változat DOI
Borító:
Saját polcon: