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001-es BibID:	BIBFORM001084
Első szerző:	Chen-Izu, Ye
Cím:	Phosphorylation of RyR2 and shortening of RyR2 cluster spacing in spontaneously hypertensive rat with heart failure / Chen-Izu Y., Ward C. W., Stark W., Bányász T., Sumandea M. P., Balke W., Izu L. T., Wehrens X. H. T.
Dátum:	2007
ISSN:	0363-6135 (Print)
Megjegyzések:	As a critical step toward understanding the role of abnormal intracellular Ca(2+) release via the ryanodine receptor (RyR(2)) during the development of hypertension-induced cardiac hypertrophy and heart failure, this study examines two questions: 1) At what stage, if ever, in the development of hypertrophy and heart failure is RyR(2) hyperphosphorylated at Ser(2808)? 2) Does the spatial distribution of RyR(2) clusters change in failing hearts? Using a newly developed semiquantitative immunohistochemistry method and Western blotting, we measured phosphorylation of RyR(2) at Ser(2808) in the spontaneously hypertensive rat (SHR) at four distinct disease stages. A major finding is that hyperphosphorylation of RyR(2) at Ser(2808) occurred only at late-stage heart failure in SHR, but not in age-matched controls. Furthermore, the spacing between RyR(2) clusters was shortened in failing hearts, as predicted by quantitative model simulation to increase spontaneous Ca(2+) wave generation and arrhythmias.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	American Journal of Physiology. Heart and Circulatory Physiology 293 (2007), p. 2409-2417. -
További szerzők:	Ward, C. W. Stark, W. Bányász Tamás (1960-) (élettanász) Sumandea, M. P. Balke, C. William Izu, Leighton T. Wehrens, X. H. T.
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