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001-es BibID:	BIBFORM001213
Első szerző:	Szegedi István (hematológus, onkológus, nefrológus)
Cím:	Long-lasting partial remission by Interferon-alpha treatment in a child with essential thrombocythemia / István Szegedi, Ilona Benkő, Gabriella Merő, Ágota Prinzinger, János Kappelmayer, Csongor Kiss
Dátum:	2007
Megjegyzések:	Essential thrombocythemia (ET) is a clonal myeloproliferative disorder characterized by sustained thrombocytosis, isolated hyperplasia of megakaryocytic lineage, and association with thrombotic or bleeding episodes. It is extremely rare in childhood and frequently presents without evident clinical signs. We describe a 3-year-old girl with severe headache and dizziness suffering from ET, who was treated with Interferon-alpha-2a (IFN) based on the potent effect of this agent to inhibit myeloid colonies induced by phytohemagglutinin A stimulated leukocyte conditioned medium (PHA-LCM). Bone-marrow-derived mononuclear cells of this patient did not exhibit spontaneous colony formation but responded to recombinant human (rh) erythropoietin (EPO), rh granulocyte-colony stimulating factor (G-CSF), granulocyte-macrophage (GM)-CSF, and stem-cell factor in addition to PHA-LCM. After 65 months of in vivo IFN treatment, the patient experienced a sustained partial remission with platelet counts varying between 400 and 600 x 103/gamma l.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban childhood essential thrombocythemia hematopietic colony formation interferon-alpha
Megjelenés:	Pediatric Blood and Cancer. - 49 : 5 (2007), p. 744-747. -
További szerzők:	Benkő Ilona (1954-) (orvos, farmakológus) Merő Gabriella (1967-) (gyermekneurológus) Prinzinger Ágota Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:	elektronikus változat DOI
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