Találati lista | Tudóstér

001-es BibID:	BIBFORM001510
Első szerző:	Zsuga Judit (neurológus, pszichoterapeuta, egészségügyi szakmanager)
Cím:	Dimethylarginines at the crossroad of insulin resistance and atherosclerosis / Judit Zsuga, János Török, Mária T. Magyar, Attila Valikovics, Rudolf Gesztelyi, Ágota Lenkey, László Csiba, Sándor Kéki, Miklós Zsuga, Dániel Bereczki
Dátum:	2007
Megjegyzések:	We tested if asymmetric dimethylarginine (ADMA)contributes to the simultaneous evolution of atherosclerosis and insulin resistance. We investigated the significant predictors of insulin resistance in the context of atherosclerosis, focusing on the role ADMA, symmetric dimethylarginine (SDMA), and l-arginine play in a cohort of young atherosclerotic patients and their age-matched controls. In a case-control study, 60 patients younger than 55 years having at least 30% stenosis of the internal carotid artery and 30 age- and sex-matched controls were recruited at a community-based neurosonologic laboratory. We found a strong positive association between the homeostasis model assessment of beta-cell function and insulin resistance and the ADMA/SDMA ratio that remained statistically significant even after adjusting for all significant and a priori identified determinants (beta = 6.76; 95% confidence interval [CI], 2.13-11.39; P = .005). Interestingly, this relationship was even more pronounced in the atherosclerotic stratum (beta = 8.29; 95% CI, 1.43-15.15; P = .019), whereas, on multiple linear regression, lack of association was seen in subjects free of carotid atherosclerosis (beta = 1.39; 95% CI, -5.46 to 8.26; P = .671). We conclude that ADMA/SDMA ratio is a significant determinant of insulin resistance and may be a better parameter to monitor than ADMA alone. By accounting for the competition at the y+ transporters, ADMA/SDMA ratio could be an indicator of intracellular ADMA level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Metabolism: Clinical and Experimental 56 : 3 (2007), p. 394-399. -
További szerzők:	Török János Magyar Mária Tünde (1970-) (neurológus) Valikovics Attila Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Lenkey Ágota (1944-) (biológus) Csiba László (1952-) (neurológus, pszichiáter) Kéki Sándor (1964-) (polimer kémikus) Zsuga Miklós (1944-) (polimer kémikus) Bereczki Dániel (1960-) (neurológus)
Internet cím:	DOI elektronikus változat
Borító:
Saját polcon: