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001-es BibID:BIBFORM002763
Első szerző:Panyi György (biofizikus)
Cím:Probing the cavity of the slow inactivated conformation of shaker potassium channels / Panyi G., Deutsch C.
Dátum:2007
Megjegyzések:Slow inactivation involves a local rearrangement of the outer mouth of voltage-gated potassium channels, but nothing is known regarding rearrangements in the cavity between the activation gate and the selectivity filter. We now report that the cavity undergoes a conformational change in the slow-inactivated state. This change is manifest as altered accessibility of residues facing the aqueous cavity and as a marked decrease in the affinity of tetraethylammonium for its internal binding site. These findings have implications for global alterations of the channel during slow inactivation and putative coupling between activation and slow-inactivation gates
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
binding Sites
biophysics
cadmium
cell Line
chemistry
genetics
humans
Hungary
ion channel gating
kinetics
membrane Potentials
metabolism
Models, Biological
Models, Molecular
Mutagenesis, Site-Directed
Patch-Clamp Techniques
Potassium
Potassium Channel Blockers
Potassium Channels
Protein Conformation
Research
Shaker Superfamily of Potassium Channels
Support
Tetraethylammonium
Transfection
Megjelenés:The Journal of General Physiology. - 129 : 5 (2007), p. 403-418. -
További szerzők:Deutsch, Carol
Internet cím:DOI
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