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001-es BibID:	BIBFORM003460
Első szerző:	Gombos Katalin
Cím:	Characterization of microarray gene expression profiles of early stage thyroid tumours / Katalin Gombos, Eszter Szele, István Kiss, Timea Varjas, László Puskás, László Kozma, Ferenc Juhász, Erik Kovács, István Szanyi, István Ember
Dátum:	2007
Megjegyzések:	Microarray analysis offers the opportunity of screen ing transcriptional expression ptofile of neoplastic celis on a genomic level. Defining consistent changes in gene expression patrem of tumours enables the deiection of genes essential for tumorigenesis and might provide biomarkers to early recognition of malignant behaviourand new therapeutical targets. Patients and Methods: A high-density oligonucleotide wray with 20,000 human gene-specific oligonucleotide was used to analyze benign and earlYcstage malignant thyroid tumours of epithelial origin: folliatlar adenoma, foliicular carcinoma and papillary carcinoma, compw'ed to normal thyroid tissue. Results: Significant expression dijferences of 279 genes - underexpression of 252 and overexpression of 27 gen es - were found. The overlappinggenes of the different histological types were examined extenSively. Among thesegenes a limited set acting on the same transcriptional path way. through NF-KB; were found. Conc1usion: The role of overlapping genes in histologicaliy different tumours has not been c1arified, but might represent early or pivotaf steps of carcinogenesis. Ali investigated histiotypes of tumourscontciined signijicantly modulated genes acting on the NE-KB regulatOlY pathway. Our findings suggest that modulation of NF-KB signcMling plays a cn/cial role in early thyroid carcínogenesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban gene expression profiling thyroid tumour follicular adenoma follicular carcinoma papillary carcinoma microarray
Megjelenés:	Cancer Genomics and Proteomics. - 4 : 6 (2007), p. 403-410. -
További szerzők:	Szele Eszter Kiss István (orvos) Varjas Tímea Puskás László Kozma László (orvos) Kovács Erik Szanyi István Ember István Juhász Ferenc (1952-) (sebész)
Internet cím:	elektronikus változat
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