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001-es BibID:	BIBFORM003505
Első szerző:	Sulowicz, Wladyslaw
Cím:	Discontinuation of mycophenolate mofetil from a tacrolimus-based triple regimen 2 months after renal transplantation : a comparative randomized multicentre study / Wladyslaw Sulowicz, Petr Bachleda, Andrzej Rydzewski, Boleslaw Rutkowski, Péter Szakály, László Asztalos, Jiri Samlik, Eva Lacková, Andrzej Ksiazek, Pavel Studenik, Michal Mysliwiec, Zbigniew Hruby, Pavel Navrátil, Janusz Gumprecht
Dátum:	2007
Megjegyzések:	Previous clinical data suggested that with a tacrolimus-based regimen adjunctive immunosuppressives may be withdrawn after an initial treatment period. This study investigated the early discontinuation of mycophenolate mofetil (MMF) from a standard triple regimen. Patients were randomized either to receive a continued tacrolimus/MMF/steroids triple regimen (control group) or to reduce and then stop the MMF dose (MMF stop group). Both groups received identical daily tacrolimus and corticosteroid doses. The initial MMF dose was 1 g/day in both arms, but in the MMF stop group the dose was reduced to 0.5 g/day from week 7 to week 12 and then stopped. The intent-to-treat population consisted of 74 (control) and 78 (MMF stop) patients. MMF was tapered off as planned in 82.9 % of the patients in the MMF stop arm. The 6-month incidence of biopsy-proven acute rejection was similar in both arms (21.6% control, 16.7% MMF stop). Graft loss occurred in 5.4% (control) and 3.8% (MMF stop) of the patients. MMF could be safely discontinued from a tacrolimus-based triple therapy early after transplantation without any rebound in efficacy during the 6-month follow-up period.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban immunosuppression mycophenolate mofetil renal transplantation tacrolimus
Megjelenés:	Transplant International. - 20 : 3 (2007), p. 230-237. -
További szerzők:	Bachleda, Petr Rydzewski, Andrzej Rutkowski, Boleslaw Szakály Péter Samlik, Jiri Lacková, Eva Ksiazek, Andrzej Studenik, Pavel Mysliwiec, Michal Hruby, Zbigniew Navrátil, Pavel Gumprecht, Janusz Asztalos László (1951-) (sebész)
Internet cím:	elektronikus változat DOI
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