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001-es BibID:	BIBFORM003514
Első szerző:	Lőcsey Lajos (belgyógyász, nephrológus)
Cím:	Relationship between metabolic alterations, arterial stiffness and cardiovascular disease after kidney transplantation / Lajos Lőcsey, László Szabó, Anikó Dán, Roland Fedor, László Asztalos
Dátum:	2008
Megjegyzések:	Objective: The vascular, arterial stiffness is an independent predictor cardiovascular risk factor, the associated aging, hypertension and cardiovascular disease. The augmentation index (AIx) and pulse wave velocity (PWV) are early markers for atherosclerotic vascular changes. Methods: We examined 81 male, 64 female (45,3 +- 11,2 years) renal transplanted pts, measured systolic, diastolic blood, and pulse pressure (PP) and AIx, PWV with TensioClinic (TensioMed) arteriograph, and cardiovascular risk was assessed by echocardiography and ultrasonography of carotid arteries. The thickness of left ventricular wall, the ejection fraction and the stenosis of carotid arteries were measured. We determined BMI, ICW/ECW, FM and visceral fat surface (VFA) with bioimpedance analyser (InBody 720-Biospacc). We measured is fasting serum creatinine, cystatin C, homocysteine, CRP, iPTH, lipids and Ca x P levels. Results: The serum cystatin C 2,1 +- 0,2 mg/l, homocysteine 15,2 +- 2,6 umol/l, with hyper- cholesterolaemia, high LDL and ApoB levels. After transplantation significantly increased BMI, FM and VFA (p<0,01). The AIx increased 20 % of men, and 37 % of females (<10 %), PWV increased in 43 % of men, 34 % of females (>10 m/s). PP was pathological high 12-12 % of pts. The PWV was significantly related to age (r=0,52), thickness of the ventricular wall (r=0,46). PP, BM1, systolic and diastolic blood pressure correlated positively but modestly with PWV. The was significant relationship between AIx80 and systolic (r=0,42). Diastolic (r=0,39) blood pressure and PP (r=0,33). Ejection fraction negatively correlated with PWV and AIx. There was strong association between carotid artery stenosis and PWV, AIx80. All pts with greater than 10m/s had carotid stenosis. The pathological high AIx80 (>10%) and PWV (>12m/s) can be found high BM1, FM, VFA and increased PP, systolic diastolic blood pressure, MAP with dyslipidaemia, high Ca x P (>4,4), iPTH (>160 pmol/l) levels. Conclusions: The arteriograph an objective, portabile, non-invasive, convenient method for the early diagnosis and follow-up of atherosclerosis, arterial calcification and stiffness. After kidney transplantation in metabolic, dyslipidaemic alterations are Increased AIx80 and PWV. Repairment of endothel function and prevention of atherosclerosis may help to reduce cardiovascular complications.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok előadáskivonat Abstract
Megjelenés:	XXII. International Congress of the Transplantation Society 10-14, August, 2008, Sydney, Australia. - p. 5.
További szerzők:	Dán Anikó Fedor Roland (1975-) (sebész) Asztalos László (1951-) (sebész) Szabó László (1975-) (sebész)
Internet cím:	elektronikus változat
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