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001-es BibID:	BIBFORM004631
Első szerző:	Gáspár Rezső (biofizikus)
Cím:	Evidence of non-synaptic regulation of postpartum uterine contractility in the rat / Gaspar, R., Marki, A., Zupko, I., Falkay, G.
Dátum:	1998
ISSN:	024-3205
Megjegyzések:	Myometrial tissue rings from postpartum rats (24 h after delivery) were studied in vitro by electric field stimulation, and the alpha1/beta2-adrenoceptor ratio was determined by a radioligand binding technique. Pregnancy-denervated uterine rings were stimulated by long-duration pulses (100 ms). The contractions were inhibited by beta2-agonists (terbutaline and fenoterol) and alpha-antagonists (phentolamine, urapidil and yohimbine) in a concentration-dependent manner. Their effects were not altered by the adrenergic neuron-blocking agent bretylium. The alpha-antagonists (except phentolamine) elicited the same maximal inhibition as the beta2-agonists. Receptor assays revealed that the alpha1/beta2 ratio was about 2 in the measured uteri. It was concluded that the inhibitory effects of alpha-antagonists and beta2-agonists are mediated via non-synaptic adrenoceptors of the denervated postpartum rat uterus. The same inhibitory activity could be explained by the greater amount of alpha-receptors. It is believed that this is the first functional proof of the existence of non-synaptic alpha1-adrenoceptors in smooth muscle.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adrenergic beta-Agonists Animal Binding Sites Electric Stimulation Female Fenoterol Hungary In Vitro Male Myometrium pharmacology physiology Puerperium Radioligand Assay Rats Rats, Sprague-Dawley Receptors, Adrenergic, alpha Receptors, Adrenergic, alpha-1 Receptors, Adrenergic, beta Support, Non-U.S.Gov't Synapses Terbutaline ultrastructure Uterine Contraction Uterus
Megjelenés:	Life Sciences. - 62 : 12 (1998), p. 1119-1124. -
További szerzők:	Márki A. Zupkó István Falkay György
Internet cím:	elektronikus változat elektronikus változat
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