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001-es BibID:	BIBFORM004637
Első szerző:	Recchioni, Rina
Cím:	Melatonin increases the intensity of respiratory burst and prevents L-selectin shedding in human neutrophils in vitro / Recchioni, R., Marcheselli, F., Moroni, F., Gaspar, R., Damjanovich, S., Pieri, C.
Dátum:	1998
ISSN:	006-291X
Megjegyzések:	Effects of melatonin priming of neutrophils and subsequent increase of phorbol 12-miristate 13-acetate stimulated respiratory burst were investigated on the modulation of L-selectin shedding and MAC-1 upregulation. Respiratory burst related H2O2 production and adhesion molecule expression were quantified by flow cytometry. Phorbol 12-miristate 13-acetate dose dependence of intracellular oxidation and adhesion molecule expression showed no relationship between respiratory burst intensity and MAC-1 expression or L-selectin shedding. Treatment of cells with 12.5 nM phorbol 12-miristate 13-acetate resulted in less than 20% of the respiratory burst response, however it induced 91.7% of total MAC-1 expression and 62.8% of L-selectin shedding. Melatonin priming experiments showed also no connection between the extent of respiratory burst and MAC-1 expression, however melatonin priming almost completely prevented L-selectin down-regulation elicited by phorbol 12-miristate 13-acetate, without affecting MAC-1 expression. It is suggested that melatonin may inhibit metalloproteases responsible for L-selectin cleavage
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban biosynthesis blood Dose-Response Relationship,Drug drug effects Flow Cytometry Human Hydrogen Peroxide In Vitro Kinetics L-Selectin Macrophage-1 Antigen Melatonin Neutrophils pharmacology physiology Research Respiratory Burst Rhodamine 123 Support, Non-U.S.Gov't Tetradecanoylphorbol Acetate
Megjelenés:	Biochemical and Biophysical Research Communications. - 252 : 1 (1998), p. 20-24. -
További szerzők:	Marcheselli, Fiorella Moroni, Fausto Gáspár Rezső (1944-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Pieri, Carlo
Internet cím:	elektronikus változat elektronikus változat
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