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001-es BibID:	BIBFORM004832
035-os BibID:	(scopus)12144266330 (wos)000225455700015
Első szerző:	Citri, Ami
Cím:	Hsp90 restrains ErbB-2/HER2 signalling by limiting heterodimer formation / Citri, A., Gan, J., Mosesson, Y., Vereb, G., Szollosi, J., Yarden, Y.
Dátum:	2004
Megjegyzések:	ErbB-2/HER2 is an oncogenic tyrosine kinase that regulates a signalling network by forming ligand-induced heterodimers with several growth factor receptors of the ErbB family. Hsp90 and co-chaperones regulate degradation of ErbB-2 but not other ErbB members. Here, we report that the role of Hsp90 in modulating the ErbB network extends beyond regulation of protein stability. The capacity of ErbB-2 to recruit ligand-bound receptors into active heterodimers is limited by Hsp90, which is dissociated from ErbB-2 following ligand-induced heterodimerization. We show that Hsp90 binds a specific loop within the kinase domain of ErbB-2, thereby restraining heterodimer formation and catalytic function. These results define a role for Hsp90 as a molecular switch regulating the ErbB signalling network by limiting formation of ErbB-2-centred receptor complexes.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Amino Acid Motifs Amino Acid Sequence Dimerization HSP90 Heat-Shock Proteins metabolism Molecular Sequence Data physiology Proteins Receptor,erbB-2 Research Signal Transduction Support
Megjelenés:	EMBO Reports. - 5 : 12 (2004), p. 1165-1170. -
További szerzők:	Gan, Judith Mosesson, Yaron Vereb György (1965-) (biofizikus, orvos) Szöllősi János (1953-) (biofizikus) Yarden, Yosef
Internet cím:	elektronikus változat DOI
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