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001-es BibID:	BIBFORM004927
Első szerző:	Gáspár Rezső (biofizikus)
Cím:	Tetrodotoxin-sensitive fast Na+ current in embryonic chicken osteoclasts / Rezső Gáspár, A. Freek Weidema, Zoltán Krasznai, Peter J. Nijweide, Dirk L. Ypey
Dátum:	1995
ISSN:	0031-6768
Megjegyzések:	A voltage-dependent, fast, transient inward current was characterized in embryonic chicken osteoclasts using the permeabilized patch configuration of the patch-clamp technique. The current was activated by depolarizations to higher than -28 +/- 4 mV from a holding potential of -80 mV. It peaked within 1-1.5 ms, and inactivated within 3.3-6.9 ms. The 50% inactivation voltage was -59 +/- 6 mV with a steepness factor of 0.11 +/- 0.06. The current disappeared with the removal of extracellular Na+ and was reversibly blocked by tetrodotoxin (K0.5 < 15 nM) but not by verapamil (< or = 100 microM). We conclude that this new current in embryonic chicken osteoclasts is a sodium current known from excitable cells.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Animal Chick Embryo Culture Media drug effects Hungary In Vitro metabolism Osteoclasts Patch-Clamp Techniques pharmacology Sodium Sodium Channels Support,Non-U.S.Gov't Tetrodotoxin Verapamil
Megjelenés:	Pflügers Archiv. - 430 : 4 (1995), p. 596-598. -
További szerzők:	Weidema, Adam Freek (biofizikus) Krasznai Zoltán (1950-) (biofizikus) Nijweide, Peter J. Ypey, Dirk L.
Internet cím:	DOI
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