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001-es BibID:	BIBFORM005090
Első szerző:	Nagy Péter (biofizikus)
Cím:	ICAM-1 inhibits the homocluster formation of MHC-I in colon carcinoma cells / Nagy, P., Vamosi, G., Damjanovich, S., Damjanovich, L.
Dátum:	2006
ISSN:	006-291X (Print)
Megjegyzések:	ICAM-1 and MHC-I proteins play fundamental roles in antigen presentation, activation of T lymphocytes, and immune responses against tumor cells. Both of them participate in the formation of lipid raft-associated membrane protein clusters. We found significant colocalization between ICAM-1 and MHC-I at the level of large-scale associations. We combined RNA interference and fluorescence resonance energy transfer studies to show that ICAM-1 promotes the partial disassembly of MHC-I homoclusters on LS-174T colon carcinoma cells. Interferon-gamma (IFN-gamma) treatment induced an increase in the expression of MHC-I and ICAM-1 resulting in decreased MHC-I homoassociation. Small interfering RNAs directed against ICAM-1 restored the homoassociation of MHC-I without influencing the expression level of MHC-I by eliminating ICAM-1 molecules interspersed in MHC-I clusters. We conclude that the composition of membrane protein clusters is dynamically altered in response to both physiological and experimentally elicited changes in antigen expression levels.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antigen Presentation Antigens Biophysics Carcinoma Cell Line, Tumor Cells Colonic Neoplasms Energy Transfer Fluorescence Fluorescence Resonance Energy Transfer genetics Histocompatibility Antigens Histocompatibility Antigens Class I Humans Hungary Intercellular Adhesion Molecule-1 Lymphocytes metabolism Protein Binding Proteins Research RNA,Small Interfering Support T-Lymphocytes
Megjelenés:	Biochemical and Biophysical Research Communications. - 347 : 3 (2006), p. 758-763. -
További szerzők:	Vámosi György (1967-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus) Damjanovich László (1960-) (általános sebész)
Internet cím:	DOI elektronikus változat
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