Találati lista | Tudóstér

001-es BibID:	BIBFORM005175
Első szerző:	Dóczy-Bodnár Andrea (biofizikus)
Cím:	A biophysical approach to IL-2 and IL-15 receptor function : localization, conformation and interactions / Bodnar, A., Nizsaloczki, E., Mocsar, G., Szaloki, N., Waldmann, T. A., Damjanovich, S., Vamosi, G.
Dátum:	2008
Megjegyzések:	Interleukin-2 and interleukin-15 (IL-2, IL-15) are key participants in T and NK cell activation and function. Sharing the beta and gamma receptor subunits results in several common functions: e.g. the promotion of T cell proliferation. On the other hand, due to their distinct alpha receptor subunits, they also play opposing roles in immune processes such as activation induced cell death and immunological memory. Divergence of signaling pathways must ensue already at the plasma membrane where the cytokines interact with their receptors. Therefore understanding molecular details of receptor organization and mapping interactions with other membrane proteins that might influence receptor conformation and function, are of key importance. Biophysical/advanced microscopic methods (fluorescence resonance energy transfer (FRET), fluorescence crosscorrelation spectroscopy (FCCS), near-field scanning optical microscopy (NSOM), X-ray crystallography, surface plasmon resonance, NMR spectroscopy) have been instrumental in clarifying the details of receptor structure and organization from the atomic level to the assembly and dynamics of supramolecular clusters. In this short review some important contributions shaping our current view of IL-2 and IL-15 receptors are presented.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Antibodies Apoptosis Biophysics blood Carcinoma Cell Differentiation Cell Fusion Cell Line Cell Membrane Cell Proliferation Cells Complement Confocal microscopy Dendritic Cells Diffusion Energy Transfer Epidermal Growth Factor Fibroblasts Fluorescence Fluorescence correlation spectroscopy Fluorescence Resonance Energy Transfer FRET Homeostasis Human Hungary IL-2 and IL-15 receptors In Vitro Insulin Interleukin-15 Interleukin-2 Kinetics Lymphocytes Lymphoma Melanoma Membrane Microdomains Membrane Proteins metabolism methods Mice Microscopy Near-field scanning optical microscopy Phagocytosis Phosphorylation Photobleaching Protein-protein interactions Proteins Receptor patterns Research Signal Transduction Structure determination Support therapy transmembrane signaling Tyrosine X-ray crystallography
Megjelenés:	Immunology Letters. - 116 : 2 (2008), p. 117-125. -
További szerzők:	Nizsalóczki Enikő Mocsár Gábor (1981-) (biofizikus) Szalóki Nikoletta (1981-) (biológus) Waldmann, Thomas A. Damjanovich Sándor (1936-2017) (biofizikus) Vámosi György (1967-) (biofizikus)
Internet cím:	elektronikus változat elektronikus változat DOI
Borító:
Saját polcon: