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001-es BibID:	BIBFORM005686
Első szerző:	Calpe, Silvia
Cím:	The SLAM and SAP gene families control innate and adaptive immune responses / Silvia Calpe, Ninghai Wang, Xavier Romero, Scott B. Berger, Arpad Lanyi, Pablo Engel, Cox Terhorst
Dátum:	2008
Megjegyzések:	The nine SLAM-family genes, SLAMF1-9, a subfamily of the immunoglobulin superfamily, encode differentially expressed cell-surface receptors of hematopoietic cells. Engagement with their ligands, which are predominantly homotypic, leads to distinct signal transduction events, for instance those that occur in the T or NK cell immune synapse. Upon phosphorylation of one or more copies of a unique tyrosine-based signaling motif in their cytoplasmic tails, six of the SLAM receptors recruit the highly specific single SH2-domain adapters SLAM-associated protein (SAP), EAT-2A, and/or EAT-2B. These adapters in turn bind to the tyrosine kinase Fyn and/or other protein tyrosine kinases connecting the receptors to signal transduction networks. Individuals deficient in the SAP gene, SH2D1A, develop an immunodeficiency syndrome: X-linked lympho-proliferative disease. In addition to operating in the immune synapse, SLAM receptors initiate or partake in multiple effector functions of hematopoietic cells, for example, neutrophil and macrophage killing and platelet aggregation. Here we discuss the current understanding of the structure and function of these recently discovered receptors and adapter molecules in the regulation of adaptive and innate immune responses.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Linked Lymphoproliferative-Disease Lymphocitic Activation Molecule Epstein-Barr-Virus Natural-Killer-Cells Huan NK Cells Systemic-Lupus-Erythematosus CD8(+) T-Cells Common Variable Immunodeficiency Human B-Lymphocytes Receptor 2B4 CD244
Megjelenés:	Advances in Immunology. - 97 (2008), p. 177-250. -
További szerzők:	Wang, Ninghai Romero, Xavier Berger, Scott B. Lányi Árpád (1962-) (biológus, immunológus) Engel, Pablo Terhorst, Cox
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