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001-es BibID:	BIBFORM005975
Első szerző:	Edidin, Michael
Cím:	Lateral diffusion measurements give evidence for association of the Tac peptide of the IL-2 receptor with the T27 peptide in the plasma membrane of HUT-102-B2 T cells / M. Edidin, A. Aszalos, S. Damjanovich, T.A. Waldmann
Dátum:	1988
Megjegyzések:	Fluorescence photobleaching recovery measurements show that the F1-IgG-labeled Tac peptide of the IL-2R can diffuse in the plane of the membrane of HUT-102-B2 T lymphocytes, with a mean diffusion coefficient of 2 to 3 x 10(-10) cm2s-1. Although only a fraction (mean 37%) of the Tac peptides is mobile on any given cell, lateral diffusion of the Tac peptide can be measured in 94% of cells examined. In contrast, the 95-kDa peptide, T27, is 90 to 100% immobilized in cells labeled with OKT27. Immobilization of T27 also affects the lateral diffusion of the Tac peptide, because the Tac peptide is immobile in more than 30% of cells pretreated with OKT27 and then labeled with anti-Tac IgG. The effect is specific for OKT27 to the extent that pretreatment with an anti-HLA mAb does not immobilize the Tac peptide. It appears, then, that Tac and T27 peptide not only are in proximity on HUT-102-B2 lymphocyte membranes but also interact physically in situ.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Antibodies,Monoclonal Antigens,CD27 Antigens,Surface Cell Line Diffusion Fluorescence HLA Antigens Human immunology Interleukin-2 Lymphocytes Membrane Proteins metabolism Peptides physiology Receptors,Immunologic Receptors,Interleukin-2 Support,U.S.Gov't,P.H.S. T-Lymphocytes
Megjelenés:	The Journal of Immunology. - 141 : 4 (1988), p. 1206-1210. -
További szerzők:	Aszalos Adorján Damjanovich Sándor (1936-2017) (biofizikus) Waldmann, Thomas A.
Internet cím:	elektronikus változat
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