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001-es BibID:	BIBFORM006004
035-os BibID:	(scopus)0021296515 (wos)A1984SD26500012
Első szerző:	Szabó Gábor (biofizikus)
Cím:	A follow-up study of the development of Rauscher erythroleukemia / Gábor Szabó, László Mátyus
Dátum:	1984
Megjegyzések:	Expression of cell membrane antigens recognized by antiserum raised against purified Friend murine leukemia virus (Fr-MuLV) envelope glycoprotein (gp71) and by xenotropic MuLV-coded cell surface antigen (XenCSA) specific antibodies was studied in the course of the development of Rauscher erythroleukemia in the spleen of Balb/c mice. DNA content vs immunofluorescence or light scattering of cells were simultaneously analyzed. At early stages of the disease (4-5 days after infection) the gp71 and XenCSA-related antigen expression is enhanced mainly on S-G2/M-phase cells as compared to the majority of G1-phase cells or to the endogenous background of uninfected cells. Later (around 10 days after infection) an approximately ten-fold increased gp71-related antigen density is reached in every phase of the cell cycle. These data show that the virus-induced transition from resting to proliferating state is coupled to enhanced expression of both helper and defective viral env-gene products in the cell membrane of mitotic and G1-phase cells as well.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk analysis Animal Antibodies Antigens,Surface Cell Cycle Cell Membrane Comparative Study Dna DNA,Neoplasm etiology Flow Cytometry Follow-Up Studies immunology Leukemia,Erythroblastic,Acute Light Mice Rauscher Virus Spleen Support,Non-U.S.Gov't Tumor Virus Infections
Megjelenés:	Cytometry. - 5 : 1 (1984), p. 92-95. -
További szerzők:	Mátyus László (1956-) (biofizikus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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