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001-es BibID:	BIBFORM006029
Első szerző:	Damjanovich Sándor (biofizikus)
Cím:	Electroimmunology : membrane potential, ion-channel activities, and stimulatory signal transduction in human T lymphocytes from young and elderly / Damjanovich S., Pieri C.
Dátum:	1991
Megjegyzések:	There are conflicting data on the functional role and direction of the changes in membrane potential and ion currents accompanying lymphocyte stimulation. Recently, we discovered that a known sodium channel opener, bretylium tosylate (BT), may influence the stimulatory processes of lymphocyte activation at more than one site. Parallel flow cytometric and electrophysiological measurements with patch clamp techniques showed that BT quickly repolarizes previously slightly depolarized human peripheral blood as well as splenic murine lymphocytes. The repolarization occurred through opening ligand- and voltage-gated, hitherto unknown sodium channels, and the sodium influx activated Na(+)-K(+)-dependent, electrogenic ATP-ase activity. A comparison of the flexible responsiveness of the membrane potential was carried out between lymphocytes from young and elderly using the above mechanism and a number of combinations of channel blockers and ionophores in order to obtain information on the alleged changes in immunological behavior. A significant difference has been found between lymphocytes from human young and elderly volunteers in the readiness to respond to channel-activating perturbations. An explanation is offered, based upon known physicochemical changes in the plasma membrane during aging.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Age Factors Aged Aging blood Bretylium Tosylate Cell Membrane Human Hungary immunology Ion Channels Ionophores Lymphocytes Membrane Potentials physiology Signal Transduction Sodium Sodium Channels T-Lymphocytes
Megjelenés:	Annals of the New York Academy of Sciences. - 621 (1991), p. 29-39. -
További szerzők:	Pieri, Carlo
Internet cím:	elektronikus változat
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