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001-es BibID:	BIBFORM006058
Első szerző:	Weidema, Adam Freek (biofizikus)
Cím:	A Ca2+-dependent K+-channel in freshly isolated and cultured chick osteoclasts / Adam F. Weidema, Jan H. Ravesloot, György Panyi, Peter J. Nijweide, Dirk L. Ypey
Dátum:	1993
ISSN:	0005-2736
Megjegyzések:	Calcium-activated potassium channels were found in embryonic chick osteoclasts using the patch-clamp technique. The activity of the channel was increased by both membrane depolarisation and an increase in intracellular Ca2+ concentration in the range 10(-5) to 10(-3) M. In the cell-attached-patch configuration the channel was only active at extreme depolarising potentials. Ca2+ addition to the cytoplasm via ionomycin increased channel activity at the resting membrane potential of the osteoclast. The channel had a single-channel conductance of 150 pS in the inside-out patch under symmetrical K+ conditions (150 mM) and was selective for potassium ions. During sustained application of increased [Ca2+] at the cytoplasmic side of inside-out patches, channel activity sometimes decreased again after the initial increases (desensitization). The results established the properties of the single channels underlying an outward rectifying K+ conductance in chick osteoclasts described previously by us.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Potassium ion channel Calcium ion dependence Patch clamp Depolarization Calcium ion concentration, intracellular Chick osteoclast
Megjelenés:	Biochimica et Biophysica Acta (BBA). Biomembranes. - 1149 : 1 (1993), p. 63-72. -
További szerzők:	Ravesloot, Jan Hindrik (1961-) Panyi György (1966-) (biofizikus) Nijweide, Peter J. Ypey, Dirk L.
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