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001-es BibID:	BIBFORM006107
Első szerző:	Boldogh István
Cím:	Colostrinin decreases hypersensitivity and allergic responses to common allergens / Istvan Boldogh, Leopoldo Aguilera-Aguirre, Attila Bacsi, Barun K. Choudhury, Alfredo Saavedra-Molina, Marian Kruzel
Dátum:	2008
Megjegyzések:	Colostrinin (TM) (CLN), isolated from mothers' pre-milk fluid (colostrum), is a uniform mixture of low-molecular-weight, proline-rich polypeptides. CLN induces neurite outgrowth of pheochromocytoma cells, extends the lifespan of diploid fibroblast cells, inhibits beta-amyloid-induced apoptosis and improves cognitive functions when administered to Alzheimer's disease patients. Objective: The aim of this study was to investigate potential allergic responses to CLN and its impact on allergic sensitization and inflammation caused by common allergens. Methods: We used a well-characterized mouse model of allergic airway inflammation. Changes in IgE/IgG1 and mucin levels, airway eosinophilia and hyperreactivity to methacholine were determined by ELISA, differential cell counting and whole-body plethysmography, respectively. Results: CLN did not increase IgE/IgG1 levels or induce cutaneous hypersensitivity reaction, airway inflammation and mucin production. Importantly, CLN significantly (p < 0.001) decreased IgE/IgG1 production, airway eosinophilia, mucin production and hypersensitivity induced by allergenic extracts from ragweed pollen grains and house dust mites. Conclusion: CLN itself is non-allergenic; however, it is effective in preventing allergic responses to known indoor and outdoor allergens. These data support the safe application of CLN and its potential use in the prevention of allergic inflammation in humans.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban colostrinin immunoglobulin E allergic inflammation
Megjelenés:	International Archives of Allergy and Immunology. - 146 : 4 (2008), p. 298-306. -
További szerzők:	Aguilera-Aguirre, Leopoldo Bácsi Attila (1967-) (immunológus) Choudhury, Barun K. Saavedra-Molina, Alfredo Kruzel, Marian L.
Internet cím:	DOI elektronikus változat
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